Reliability and validity of the EQ-5D-5L compared to the EQ-5D-3L in patients with osteoarthritis referred for hip and knee replacement

Conner‐Spady, Barbara; Marshall, Deborah A.; Bohm, Éric; Dunbar, Michael J.; Loucks, Lynda; Khudairy, Ammar Al; Noseworthy, Tom

doi:10.1007/s11136-014-0910-6

Cited by 150 publications

(111 citation statements)

References 39 publications

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“…The EQ-5D-5 L divides health into five dimensions (mobility, self-care, usual activity, pain/discomfort and anxiety/depression), each assessed with a 5-response-level questions [15]. Health states can then be weighted using country-specific ‘value sets’, which reflect the preferences of the general population.…”

Section: Methodsmentioning

confidence: 99%

Health-related quality of life and a cost-utility simulation of adults in the UK with osteogenesis imperfecta, X-linked hypophosphatemia and fibrous dysplasia

Forestier-Zhang

Watts

Turner

et al. 2016

Orphanet J Rare Dis

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BackgroundHealth-related quality of life of adults with osteogenesis imperfecta (OI), fibrous dysplasia (FD) and X-linked hypophosphatemia (XLH) remains poorly described. The aim of this study was to describe the HRQoL of adults with osteogenesis imperfecta, fibrous dysplasia and X-linked hypophophataemia and perform a cost-utility simulation to calculate the maximum cost that a health care system would be willing to pay for a hypothetical treatment of a rare bone disease.ResultsParticipants completed the EQ-5D-5 L questionnaire between September 2014 and March 2016. For the economic simulation, we considered a hypothetical treatment that would be applied to OI participants in the lower tertile of the health utility score.A total of 109 study participants fully completed the EQ-5D-5 L questionnaire (response rate 63%). Pain/discomfort was the most problematic domain for participants with all three diseases (FD 31%, XLH 25%, OI 16%).The economic simulation identified an expected treatment impact of +2.5 QALYs gained per person during the 10-year period, which led to a willing to pay of £14,355 annually for a health care system willing to pay up to £50,000 for each additional QALY gained by an intervention.ConclusionsThis is the first study to quantitatively measure and compare the HRQoL of adults with OI, FD and XLH and the first to use such data to conduct an economic simulation leading to healthcare system willingness-to-pay estimates for treatment of musculoskeletal rare diseases at various cost-effectiveness thresholds.Electronic supplementary materialThe online version of this article (doi:10.1186/s13023-016-0538-4) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Health-related quality of life and a cost-utility simulation of adults in the UK with osteogenesis imperfecta, X-linked hypophosphatemia and fibrous dysplasia

Forestier-Zhang

Watts

Turner

et al. 2016

Orphanet J Rare Dis

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“…These instruments were chosen because they are frequently used in outcome studies related to hip and knee replacement, and/or already part of nationwide joint registries, and/or available in different languages, which allows for direct comparisons with the literature. Evidence of reliability, validity and usefulness of these measures in patients undergoing TJR has been proven in numerous studies before [12][13][14][15][16][17][18][19][20][21][22][23][24][25]. The patients were also asked to rate which of the three function-related questionnaires (WOMAC, OHS/OKS and LEFS) they consider the most relevant for assessing their joint problem and which of them the easiest to complete.…”

Section: Promsmentioning

confidence: 99%

Clinical improvement and satisfaction after total joint replacement: a prospective 12-month evaluation on the patients’ perspective

et al. 2015

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“…Within the UK, the EuroQol-5D (EQ-5D) is the most commonly used preference-based measure [3], and the one recommended by NICE for HTA submissions [4]. Since 2011, a five-level version of the EQ-5D (EQ-5D-5L) has replaced the previous three-level version (EQ-5D-3L) [5], and emerging evidence indicates improved psychometric performance [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the positive emerging evidence for the psychometric properties of the ICECAP-A [32][33][34][35] and EQ-5D-5L [6][7][8][9], no evidence is yet available for the context of opiate dependence. Even though some supporting evidence for the EQ-5D-3L and other similar health-focused measures exists for this context [36][37][38][39], such measures are used with caution in economic evaluations [40,41].…”

Section: Introductionmentioning

confidence: 99%

Measuring Health and Broader Well-Being Benefits in the Context of Opiate Dependence: The Psychometric Performance of the ICECAP-A and the EQ-5D-5L

et al. 2016

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2 Key points What is already known about the topic? Treatments for substance use disorders aim at improving health and, most importantly, broader wellbeing. Health-related measures of quality of life may not adequately capture the broader wellbeing benefits associated with such complex interventions. Comprehensive evidence on the validity and responsiveness of these measures in this context is lacking. When broader capability-wellbeing benefits are expected, NICE recommends the parallel use of an ICECAP measure but their measurement properties in this context are yet unknown. What does the paper add to existing knowledge? This is the first study exploring the psychometric properties of the EQ-5D-5L and ICECAP-A measures in the context of drug addiction. The results indicate that the ICECAP-A is a promising measure for capturing both health and broader wellbeing benefits in this context. 3 ABSTRACT Background:Measuring outcomes in economic evaluations of social care interventions is

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Reliability and validity of the EQ-5D-5L compared to the EQ-5D-3L in patients with osteoarthritis referred for hip and knee replacement

Abstract: The 5L provided stronger validity evidence than the 3L, especially for dimensions relevant to this patient population-mobility, usual activities, and pain/discomfort.

Cited by 150 publications

References 39 publications

Health-related quality of life and a cost-utility simulation of adults in the UK with osteogenesis imperfecta, X-linked hypophosphatemia and fibrous dysplasia

Health-related quality of life and a cost-utility simulation of adults in the UK with osteogenesis imperfecta, X-linked hypophosphatemia and fibrous dysplasia

Clinical improvement and satisfaction after total joint replacement: a prospective 12-month evaluation on the patients’ perspective

Measuring Health and Broader Well-Being Benefits in the Context of Opiate Dependence: The Psychometric Performance of the ICECAP-A and the EQ-5D-5L

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