Reliability of sentinel lymph node biopsy with squamous cell carcinoma of the oral cavity

Minamikawa, Tsutomu; Umeda, Masahiro; Komori, Takahide

doi:10.1016/j.tripleo.2004.08.014

Cited by 24 publications

(15 citation statements)

References 36 publications

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“…Two authors individually collected data from included articles in forms commensurate with each other. Diagnostic accuracy, represented by DOR, summary receiver operating characteristic (SROC) curve, and area under the curve (AUC), was calculated 1,5,11–102 . DOR was calculated as (true positive [TP]/false positive [FP])/(false negative [FN]/true negative [TN]) to assess diagnostic accuracy with 95% confidence intervals (CIs).…”

Section: Methodsmentioning

confidence: 99%

Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis

Kim

et al. 2020

The Laryngoscope

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Objective We assessed the diagnostic accuracy of sentinel lymph node biopsy (SLNB) for detecting neck nodal metastasis in early oral squamous cell carcinoma (OSCC) as an alternative to elective neck dissection. Study Design A systematic search for relevant literature was conducted in the PubMed, SCOPUS, Embase, Web of Science, and Cochrane databases. Methods Two reviewers individually searched the five databases up to November 2019. For studies that met inclusion criteria, data on patient diagnoses were pooled, including true positives, true negatives, false positives, and false negatives. Methodological quality was checked with the Quality Assessment of Diagnostic Accuracy Studies (version 2) tool. Results In total, 98 observational or retrospective studies were included. The diagnostic odds ratio of SLNB was 326.165 (95% confidence interval [CI]: 231.477–459.587; I2 = 0%). The area under the summary receiver operating characteristic curve was 0.982. Sensitivity was 0.827 (95% CI: 0.804–0.848), and specificity was 0.981 (95% CI: 0.975–0.986). The correlation between sensitivity and the false positive rate was −0.076, which indicates that heterogeneity did not exist. Subgroup analyses were performed with the subgroups reference test type, publication year, and study type. No significant difference was found within the reference test type subgroup. However, differences within the publication year and study type subgroups were significant, where the retrospective study subgroup was significantly more sensitive and specific than the prospective study subgroup. Conclusion Results of this meta‐analysis imply that the high specificity of SLNB supports its role as a diagnostic tool for patients with clinical tumor stage (CT)1‐2 clinically negative (N0) OSCC. More studies should be done to further verify the results of this study. Level of Evidence 2a Laryngoscope, 131:E459–E465, 2021

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Section: Methodsmentioning

confidence: 99%

Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis

Kim

et al. 2020

The Laryngoscope

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“…Minamikawa et al performed SLNB in 21 patients of oral cavity SCC with clinically N0 neck [9]. They identified sentinel node in 17 of 21 cases (sensitivity 80.95 %) and it accurately predicted the metastasis in 16 cases (specificity 94 %).…”

Section: Discussionmentioning

confidence: 99%

“…Oral cavity malignancies are associated with 20-40 % risk of occult metastasis which are neither palpable during surgery nor obvious on imaging studies [6][7][8][9]. Although there are no universally accepted guidelines, still all patients with clinically N0 neck should undergo neck dissection if risk of occult metastasis is 15-20 %.…”

Section: Introductionmentioning

confidence: 99%

Sentinel Lymph Node Localization Using 1 % Isosulfan Blue Dye in Cases of Early Oral Cavity and Oropharyngeal Squamous Cell Carcinoma

Sangwan¹,

Nilakantan

Patnaik³

et al. 2014

Indian J Otolaryngol Head Neck Surg

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To study the use of 1 % isosulfan blue dye in identifying sentinel node, sensitivity and specificity of frozen section and predictive value of sentinel node in predicting other nodal status in the cases of oral cavity and oropharyngeal squamous cell carcinoma. 15 patients of oral cavity and oropharyngeal SCC with clinically N0 neck, who required WLE of the primary lesion as well as neck dissection as per recommended treatment protocol, were selected from OPD. 1 % Isosulfan dye was injected peritumorally intraoperatively after the induction of general anaesthesia. Neck dissection was performed and first node taking up the blue dye was identified, dissected, removed and was sent for frozen section. In two of the 15 cases a sentinel node was identified (sensitivity of the technique-13 %). Both the sentinel nodes were positive for presence of metastasis on final histopathology (specificity-100 %). However, five cases had nodal metastasis on final histopathological examination of the neck dissection specimen (sensitivity of sentinel lymph node biopsy-40 %). Frozen section examination had a sensitivity and specificity of 100 %. All data was analyzed using SPSS 16 software. Use of 1 % Isosulfan Dye for identification of sentinel node is a simple and cheap technique, however, it has low sensitivity as compared to the use of triple diagnostic procedure consisting of lymphoscintigraphy, per op gamma probe localization and using isosulfan dye for sentinel node identification. Sentinel lymph node is representative of nodal status and correlates well with the final histopathological examination of the dissected neck nodes.Keywords Sentinel node Á N0 neck Á Isosulfan blue dye Á Frozen section Á SLNB (sentinel lymph node biopsy)

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“…However, the accuracy of SLNB for use in SCC of the oral cavity once again became the subject of controversy in a recently published commentary: Minamikawa et al [18] question whether SLNB is capable of optimizing clinical results while limiting surgical morbidity. They assert that selective dissection of the neck must remain an important procedure in managing patients with SCC of the oral cavity.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of patients with and without sentinel lymph node biopsy (SLNB) in oral and oropharyngeal cancer: is SLNB an accurate and useful procedure?

Santaolalla¹,

Sánchez²,

Ereño

et al. 2009

Acta Oto-Laryngologica

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We observed SLNs in 21 of 22 patients, with a total of 32 SLNs detected at cervical level II (65.63%), I (21.87%), and III (12.5%). SLNB displayed a sensitivity of 73% (confidence interval (CI)=0.51-0.99) and 100% specificity (CI=1). Negative and positive predictive values were 80% and 100%, respectively. SLNB significantly reduced the incidence of radical neck dissection (p=0.003), the need for recovery/resuscitation beds after surgery (p=0.002), surgical complications (p=0.034), and length of hospital stay (p=0.01).

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Reliability of sentinel lymph node biopsy with squamous cell carcinoma of the oral cavity

Cited by 24 publications

References 36 publications

Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis

Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis

Sentinel Lymph Node Localization Using 1 % Isosulfan Blue Dye in Cases of Early Oral Cavity and Oropharyngeal Squamous Cell Carcinoma

Comparative study of patients with and without sentinel lymph node biopsy (SLNB) in oral and oropharyngeal cancer: is SLNB an accurate and useful procedure?

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