Remedial Effect of Costus ,Argel and Emblica Extracts For Hypercholesterolemic Rats . التأثير العلاجى لمستخلصات القسط والحرجل والأملج في إرتفاع الکوليسترول لدى فئران التجارب

Abstract

The ongoing study highlights the effect of some plants which include (Costus speciosus-Solenostemma Argel-Phyllanthus emblica and their mixture) to treat hypercholeaterolemia. Rat's hypercholesterolemia was induced in normal healthy male albino rats by Cholesterol feeding for 2 weeks on diet containing 1.5% cholesterol plus 10% sheep tail fat. It total number of (42) mature male albino rats of Sprague -dawley strain weighting 180-200 g rats were divided into 6 groups (7rats in each group ). One of them used as control positive(+ve)group, second as control negative(-ve) and others groups from 3-6 fed on diets and containing plants extracts at dose (400 mg/kg b.w.) for 28 days orally. At the end of experimental period blood samples were collected for serum separation to evaluate liver function (AST,ALT&ALP), kidney function (uric acid , urea & creatinine) , internal organs Weights % of b.w. , lipids profile(TG -TC-LDL-VLDL-HDL),& histopathological change of liver. Results of present investigation revealed that all tested plants improved previous phytochemical parameters, but mixtured extract(Mix) was the best treatment in practicular Histopathological changes for liver, showed remarkable recovery of liver tissues, for all groups especially the mix group which indicated maximum recovery possibly due to phytochemicals compared to livers of control (+)ve group which was showing hyperplasia of epithelial lining bile duct& fibro-plasia in portal triad ,besides sinusoidal leucocytosis. The results of present work suggestes the use of tested plantes for clinical nutrition .