Remission in ankylosing spondylitis treated with anti-TNF-  drugs: a national multicentre study

Spadaro, Antonio; Lubrano, Ennio; Marchesoni, Antonio; D’Angelo, Salvatore; Ramonda, Roberta; Addimanda, Olga; Perrotta, Fabio Massimo; Olivieri, Ignazio; Punzi, Leonardo; Salvarani, Carlo

doi:10.1093/rheumatology/ket249

Cited by 60 publications

(43 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients with earlyonset axSpA without evidence of radiographic sacroiliitis, MRI can, in fact, detect inflammatory lesions before bone damage becomes visible. As it has been seen that these patients respond quickly and effectively to anti-tumor necrosis factor-α drugs (3,(9)(10)(11), it has become urgent to identify early stages of the disease in order to begin appropriate treatment as early as possible. The Assessment of SpondyloArthritis International Society (ASAS) has recently established classification criteria for patients with suspected axSpA, including those with and without radiographic sacroiliitis (5).…”

mentioning

confidence: 99%

Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study

et al. 2016

Self Cite

View full text Add to dashboard Cite

summaryOur aim was to determine the prevalence of spine and sacroiliac joint (SIJ) lesions on magnetic resonance imaging (MRI) in patients with early axial spondyloarthritis (axSpA) and their correlation with disease activity indices. Sixty patients with low back pain (LBP) (≥3 months, ≤2 years, onset ≤45 years), attending the SpA-clinic of the Unità Operativa Complessa Reumatologia of Padova [SpondyloArthritis-Caught-Early (SPACE) study], were studied following a protocol including physical examination, questionnaires, laboratory tests, X-rays and spine and SIJ MRI. Positive spine and SIJ MRI and X-rays images were scored independently by 2 readers using the SPARCC method, modified Stoke ankylosing spondylitis spine score and New York criteria. The axial pain and localization of MRI-lesions were referred to 4 sites: cervical/thoracic/lumbar spine and SIJ. All patients were classified into three groups: patients with signs of radiographic sacroiliitis (r-axSpA), patients without signs of r-axSpA but with signs of sacroiliitis on MRI (nr-axSpA MRI SIJ+), patients without signs of sacroiliitis on MRI and X-rays (nr-axSpA MRI SIJ-). The median age at LBP onset was 29.05±8.38 years; 51.6% of patients showed bone marrow edema (BME) in spine-MRI and 56.7% of patients in SIJ-MRI. Signs of enthesitis were found in 55% of patients in the thoracic district. Of the 55% of patients with BME on spine-MRI, 15% presented presented a negative SIJ-MRI. There was a significant difference between these cohorts with regard to the prevalence of radiographic sacroiliitis, active sacroiliitis on MRI and SPARCC SIJ score. The site of pain correlated statistically with BME lesions in thoracic and buttock districts. Since positive spine-MRI images were observed in absence of sacroiliitis, we can hypothesize that this finding could have a diagnostic significance in axSpA suspected axSpA.

show abstract

mentioning

confidence: 99%

Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the baseline physical function remained a significant factor associated with HAQ over time, regardless of treatment. SpA patients on anti-TNF are expected to have good functional outcomes[44], and a short delay in diagnosis, male gender and preserved physical function were predictors of minimal disease activity (MDA) at the 5-year follow-up in a early PsA cohort[45]. However, we were not able to demonstrate the effect of anti-TNF in modulating the physical function at 6 year.…”

Section: Discussionmentioning

confidence: 83%

Predictors of functional deterioration in Chinese patients with Psoriatic arthritis: a longitudinal study

Leung

et al. 2014

BMC Musculoskelet Disord

View full text Add to dashboard Cite

BackgroundPsoriatic arthritis (PsA) disease activities at baseline may determine physical function over time. There is no longitudinal data on course of physical function in PsA patients from Asia. We aim to describe variables associated with a deterioration of physical function in PsA in Chinese over a 6-year period.Methods125 consecutive patients with PsA fulfilled the CASPAR criteria from a rheumatology outpatient center were recruited to give sociodemographic and clinical data in 2006 to 2008. Follow up interviews were conducted in 2012 to 2013 to assess physical function using Health Assessment Questionnaire (HAQ). Regression models were constructed to determine baseline variables that predict physical function on follow up.ResultsA total of 97 patients completed the follow up survey, with mean follow up time of 6.2 (±0.7) years, response rate 77.6%. PsA patients had poor physical function and health related quality of life (HRQoL) compared to normal population. There were 33% who improved in disability status and 41.2% had persistent minimal disability by HAQ categories (HAQ 0–0.49) over time. There were 14.4% of the patients who had persistent moderate disability (HAQ 0.5-1.50) and 10.3% had deterioration in disability status. There were 17.5% of patients who had deterioration in physical function as defined by an increment of HAQ score of more than 0.2 at follow up survey. Age, physical function at baseline and the number of damaged joint were significantly related HAQ at follow up.ConclusionChinese patients with PsA had had poor physical function and quality of life. One fifth of patient experienced deterioration of physical function over time. Joint damage and baseline physical function were important factors associated with poor physical function in PsA over time.

show abstract

“…n CONCLUSIONS Anti-TNF therapy showed its efficacy and safety in different rheumatic diseases and now a state of remission or low disease activity are achievable targets even in spondyloarthritis in general (42,43) and in PsA (44)(45)(46). However, about 40% of patients lack to respond to TNF inhibitors.…”

Section: Apremilastmentioning

confidence: 99%

New approved drugs for psoriatic arthritis

Perrotta

Lubrano

2016

Reumatismo

Self Cite

View full text Add to dashboard Cite

Psoriatic arthritis (PsA) is a chronic inflammatory disease that possibly leads to structural damage and to a reduction of joint function and poor quality of life. Treatment of PsA has changed since its introduction of anti- TNF drugs, which have shown to reduce the symptoms and signs of the disease and slow the radiographic progression. However, recently, the discovery of new pathogenic mechanisms have made possible the development of new molecules that target pro-inflammatory cytokines involved in skin, joint and entheseal inflammation. New drugs like ustekinumab, secukinumab and apremilast inhibit interleukin axis and intracellular pathways and showed their efficacy and safety in randomized clinical trials. These drugs have been recently approved for the treatment of PsA and included in the new EULAR and GRAPPA treatment recommendations. The aim of this paper is to briefly review the clinical trials that led to their approval for PsA.

show abstract

Remission in ankylosing spondylitis treated with anti-TNF- drugs: a national multicentre study

Abstract: Our real-life study on PR confirmed the effectiveness of ADA, ETA or INF as first or second anti-TNF-α drugs. The presence at baseline of enthesitis or psoriasis or low CRP values yielded a lower probability of obtaining PR.

Cited by 60 publications

References 31 publications

Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study

Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study

Predictors of functional deterioration in Chinese patients with Psoriatic arthritis: a longitudinal study

New approved drugs for psoriatic arthritis

Contact Info

Product

Resources

About