Remote assessment of cognitive dysfunction in hematologic malignancies using web‐based neuropsychological testing

Franco-Rocha, Oscar Y; Mahaffey, Misty L.; Matsui, William; Kesler, Shelli R.

doi:10.1002/cam4.5331

Cited by 8 publications

(3 citation statements)

References 46 publications

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“…The inclusion of racially and ethnically diverse populations are still extremely low in CRCI studies, which is consistent with findings about research studies overall (Meyers et al 2000;Hess et al 2010;Galantino et al 2012;Piccirillo et al 2015;Lawrence et al 2016;Lyon et al 2016;Amidi et al 2017;Janelsins et al 2017;Williams et al 2018Williams et al , 2020Chen et al 2018a, b;Guerrero et al 2018;Henneghan et al 2018b;Moore et al 2019;Nakamura et al 2019;Rodriguez-Wolfe et al 2019;Anderson et al 2020;Franco-Rocha et al 2023a). This may limit the generalizability of study findings to the population at large.…”

Section: Discussionsupporting

confidence: 66%

Cancer-related cognitive impairment in racial and ethnic minority groups: a scoping review

Franco-Rocha

Lewis

Longoria

et al. 2023

J Cancer Res Clin Oncol

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Purpose Disparities in cognitive function among racial and ethnic groups have been reported in non-cancer conditions, but cancer-related cognitive impairment (CRCI) in racial and ethnic minority groups is poorly understood. We aimed to synthesize and characterize the available literature about CRCI in racial and ethnic minority populations. Methods We conducted a scoping review in the PubMed, PsycInfo, and Cumulative Index to Nursing and Allied Health Literature databases. Articles were included if they were published in English or Spanish, reported cognitive functioning in adults diagnosed with cancer, and characterized the race or ethnicity of the participants. Literature reviews, commentaries, letters to the editor, and gray literature were excluded. Results Seventy-four articles met the inclusion criteria, but only 33.8% differentiated the CRCI findings by racial or ethnic subgroups. There were associations between cognitive outcomes and the participants' race or ethnicity. Additionally, some studies found that Black and non-white individuals with cancer were more likely to experience CRCI than their white counterparts. Biological, sociocultural, and instrumentation factors were associated with CRCI differences between racial and ethnic groups. Conclusions Our findings indicate that racial and ethnic minoritized individuals may be disparately affected by CRCI. Future research should use standardized guidelines for measuring and reporting the self-identified racial and ethnic composition of the sample; differentiate CRCI findings by racial and ethnic subgroups; consider the influence of structural racism in health outcomes; and develop strategies to promote the participation of members of racial and ethnic minority groups.

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Section: Discussionsupporting

confidence: 66%

Cancer-related cognitive impairment in racial and ethnic minority groups: a scoping review

Franco-Rocha

Lewis

Longoria

et al. 2023

J Cancer Res Clin Oncol

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“…Regardless, validation of the teleconsultation assessment was done in previous studies [ 8 – 10 ]. Besides, evidence concerning the feasibility and utility of telephone-based psychological and health assessments were also shown in brain tumour [ 68 ], hematologic malignancies [ 69 ] and head and neck cancer patients [ 70 ]. This is the first-ever study that uses remote neurocognitive assessments in monitoring NPC patients' cognitive functions following RT and correlating them with morphological changes and dose-volume parameters.…”

Section: Discussionmentioning

confidence: 99%

Remote assessment of cognition and quality of life following radiotherapy for nasopharyngeal carcinoma: deep-learning-based predictive models and MRI correlates

2023

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Purpose Irradiation of the brain regions from nasopharyngeal carcinoma (NPC) radiotherapy (RT) is frequently unavoidable, which may result in radiation-induced cognitive deficit. Using deep learning (DL), the study aims to develop prediction models in predicting compromised cognition in patients following NPC RT using remote assessments and determine their relation to the quality of life (QoL) and MRI changes. Methods Seventy patients (20–76 aged) with MRI imaging (pre- and post-RT (6 months–1 year)) and complete cognitive assessments were recruited. Hippocampus, temporal lobes (TLs), and cerebellum were delineated and dosimetry parameters were extracted. Assessments were given post-RT via telephone (Telephone Interview Cognitive Status (TICS), Telephone Montreal Cognitive Assessment (T-MoCA), Telephone Mini Addenbrooke’s Cognitive Examination (Tele-MACE), and QLQ-H&N 43). Regression and deep neural network (DNN) models were used to predict post-RT cognition using anatomical and treatment dose features. Results Remote cognitive assessments were inter-correlated ( r > 0.9). TLs showed significance in pre- and post-RT volume differences and cognitive deficits, that are correlated with RT-associated volume atrophy and dose distribution. Good classification accuracy based on DNN area under receiver operating curve (AUROC) for cognitive prediction (T-MoCA AUROC = 0.878, TICS AUROC = 0.89, Tele-MACE AUROC = 0.919). Conclusion DL-based prediction models assessed using remote assessments can assist in predicting cognitive deficit following NPC RT. Comparable results of remote assessments in assessing cognition suggest its possibility in replacing standard assessments. Implications for Cancer Survivors Application of prediction models in individual patient enables tailored interventions to be provided in managing cognitive changes following NPC RT. Supplementary information The online version contains supplementary material available at 10.1007/s11764-023-01371-8.

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“… 69 In recent years, efforts have been made to translate these traditional paper and pencil tests into digital formats for remote administration (e.g. Cogsuite, 70 Cogstate, 71 NIH Toolbox, 72 BrainCheck 73 ). These platforms can ease burdens related to in-person data collection for both participants and researchers and may be more sensitive to CRCI detection than paper and pencil testing.…”

Section: Discussionmentioning

confidence: 99%

Assessing cancer-related cognitive function in the context of everyday life using ecological mobile cognitive testing: A protocol for a prospective quantitative study

et al. 2023

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Objective Millions of cancer survivors are at risk for cancer-related cognitive impairment (CRCI), yet accurate and accessible assessments of cognitive functioning remain limited. Ecological mobile cognitive testing (EMCT) could offer a solution. This paper presents the protocol for a study that aims to (1) establish the reliability and validity of EMCT to assess CRCI in breast cancer survivors, and (2) prospectively evaluate within-person processes (and interactions) among context, mood, and behavior that explain cognitive variability, everyday functioning, and quality of life of cancer survivors. Methods Participants will include breast cancer survivors (>21 years old) who are within 5 years of completing chemotherapy treatment. Participants will complete two virtual visits (baseline, follow-up) 2 months apart to assess self-reported cognitive symptoms and cognitive performance, sociodemographic characteristics, clinical history, everyday functioning, and quality of life. Between virtual visits, EMCT will be used to sample cognitive functioning every other day (28 times total). We will use linear mixed-effect regressions and single-level multiple regression models to analyze the data. Results We anticipate a minimum of 124 breast cancer survivors enrolling and completing data collection. Study results will be published in peer-reviewed scientific journals. Conclusions Our findings will have broad implications for assessing CRCI in an ecologically valid and person-centered way using EMCT. We aim to provide this protocol to aid researchers who would like to apply this approach to their studies.

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Remote assessment of cognitive dysfunction in hematologic malignancies using web‐based neuropsychological testing

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 8 publications

References 46 publications

Cancer-related cognitive impairment in racial and ethnic minority groups: a scoping review

Cancer-related cognitive impairment in racial and ethnic minority groups: a scoping review

Remote assessment of cognition and quality of life following radiotherapy for nasopharyngeal carcinoma: deep-learning-based predictive models and MRI correlates

Assessing cancer-related cognitive function in the context of everyday life using ecological mobile cognitive testing: A protocol for a prospective quantitative study

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