Remote control of activity-dependent BDNF gene promoter-I transcription mediated by REST/NRSF

Hara, Daichi; Fukuchi, Mamoru; Miyashita, Toshihide; Tabuchi, Akiko; Takasaki, Ichiro; Naruse, Yoshihisa; Mori, Nozomu; Kondo, Takashi; Tsuda, Masashi

doi:10.1016/j.bbrc.2009.05.007

Cited by 38 publications

(27 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Valproic acid (VPA), another inhibitor of HDAC, also did not affect Arc expression (21). In contrast, levels of Bdnf exon I-IX mRNA, the expression of which was previously shown to be repressed by the RE-1 silencing transcription factor (REST)/HDAC-mediated mechanism (26,27), markedly increased after TSA treatment in a time-dependent manner (Fig. 6B), suggesting that TSA effectively inhibited HDAC in this culture system.…”

Section: Identification Of Bdnf-responsive Elements In Region-1 Of Thmentioning

confidence: 77%

“…The levels of Arc mRNA did not change in neurons treated with TSA. However, the levels of Bdnf exon I-IX mRNA significantly increased in a time-dependent manner upon the TSA treatment because the Bdnf promoter I is remotely repressed by the RE-1 sequence located ϳ1 kbp downstream of promoter I through HDAC-mediated repressive activity (27). These findings indicate that the repressive state of the Arc promoter differed from that of Bdnf promoter I, and that HDAC inhibition, which has been shown to accelerate the acetylation of histones, leading to the activation of gene transcription (40), was not sufficient for Arc induction.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Class I Histone Deacetylase-mediated Repression of the Proximal Promoter of the Activity-regulated Cytoskeleton-associated Protein Gene Regulates Its Response to Brain-derived Neurotrophic Factor

Nakashima

Tabuchi

Shimotori

et al. 2015

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

Background: Activity-regulated cytoskeleton-associated protein (Arc) transcription is activated by BDNF. Results: BDNF activated the Arc proximal promoter, whereas class I histone deacetylases (HDACs) inhibited this activation. Conclusion: Class I HDACs repress BDNF-induced Arc transcription through its serum response element-containing proximal promoter. Significance: Neuronal Arc expression is regulated by chromatin structure, which may lead to long-lasting changes in neuronal functions.

show abstract

Section: Identification Of Bdnf-responsive Elements In Region-1 Of Thmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Class I Histone Deacetylase-mediated Repression of the Proximal Promoter of the Activity-regulated Cytoskeleton-associated Protein Gene Regulates Its Response to Brain-derived Neurotrophic Factor

Nakashima

Tabuchi

Shimotori

et al. 2015

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…The increase in H3K9 methylation explains the lower Bdnf expression that we and others observe in the hippocampus and cortex of AD-like mice but does not reveal how or why this mark is increased. Bdnf expression is under the control of the master regulator transcription factor, neuron restrictive silencer factor (NRSF, also known as REST; Hara et al 2009). This transcription factor targets neuronal genes, including Bdnf in non-neuronal and neuronal tissues.…”

Section: Discussionmentioning

confidence: 99%

Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer’s disease

Walker

LaFerla

Oddo

et al. 2012

AGE

View full text Add to dashboard Cite

With aging and Alzheimer's disease (AD), there is an increased sensitivity to stress along with declines in the memory-associated neurotrophin brainderived neurotrophic factor in AD. We have replicated this aging phenotype in cultured neurons from aged mice despite being grown in the same environmental conditions as young neurons. This led us to hypothesize that age-related differences in epigenetic acetylation and methylation of histones are associated with age-related gene regulation. We cultured hippocampal/ cortical neurons from the 3xTg-AD mouse model and from non-transgenic mice to quantify single cell acetylation and methylation levels across the life span. In non-transgenic neurons, H3 acetylation was unchanged with age, while H4 acetylation decreased with age of the donor. Compared to nontransgenic neurons, 3xTg-AD neurons had higher levels of H3 and H4 acetylation beginning at 4 months of age. In contrast to non-transgenic neurons, 3xTg-AD neurons increased acetylation with age; 3xTg-AD neurons also responded differently to inhibition of histone deacetylases at an early age. Importantly, treatment of non-transgenic neurons with the AD peptide Aβ also elevated levels of acetylation. We also examined the repressive function of histone H3 lysine 9 (H3K9) methylation. H3K9 methylation increased with age in non-transgenic neurons, which was amplified further in 3xTg-AD neurons. The dominant effect of higher H3K9 methylation was supported by lower Bdnf gene expression in non-transgenic and 3xTg-AD mice. These data show that the epigenetic states of non-transgenic and 3xTg-AD brain neurons are profoundly different and reversible, beginning at 4 months of age when the first memory deficits are reported.

show abstract

“…In the promoter-exon (referring to the second exon) region of human, rat and mouse BDNF gene, there is one NRSE site. The outcome of interaction between NRSE and NRSF is silencing BDNF expression (Schoenherr and Anderson, 1995, Zuccato et al, 2007, Hara et al, 2009. Moreover, PD-related genes ubiquitin carboxyl-terminal hydroxylase L1 (UCH-L1) and Synapsin have been verified to be NRSF target genes (Barrachina et al, 2007).…”

Section: Introductionmentioning

confidence: 98%

NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease

et al. 2015

View full text Add to dashboard Cite

Remote control of activity-dependent BDNF gene promoter-I transcription mediated by REST/NRSF

Cited by 38 publications

References 22 publications

Class I Histone Deacetylase-mediated Repression of the Proximal Promoter of the Activity-regulated Cytoskeleton-associated Protein Gene Regulates Its Response to Brain-derived Neurotrophic Factor

Class I Histone Deacetylase-mediated Repression of the Proximal Promoter of the Activity-regulated Cytoskeleton-associated Protein Gene Regulates Its Response to Brain-derived Neurotrophic Factor

Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer’s disease

NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease

Contact Info

Product

Resources

About