Remote Ischemic Preconditioning by Hindlimb Occlusion Prevents Liver Ischemic/Reperfusion Injury

Abstract

Brief hindlimb occlusion prevents liver I/R injury. This effect appears to be related to release of HMG-B1 and is dependent on the presence of a functional TLR4. Remote ischemia preconditioning represents a novel approach to preventing distant organ injury.

Remote or Conventional Ischemic Preconditioning –Local Liver Metabolism in Rats Studied with Microdialysis

“…A quantitative comparison of serum transaminases is not possible, as the different models used to study liver IRI, R-IPC, and IPC differ significantly in the amount of liver subjected to ischemia, the length of the ischemic period, the method of preconditioning, and the animal strain [12, 15-19, 30, 33]. Moreover, the results of the R-IPC treatment compared with IRI alone in this model are coherent with earlier R-IPC studies on mice, rabbits, and rats [15][16][17]. When IPC and R-IPC are compared, the results indicate that in this model, R-IPC is less effective than central IPC as only AST levels are significantly affected.…”

“…So far it has mostly been studied in cardiac ischemia [14]. Three experimental models have shown lower levels of aminotransferases after liver IRI when then animals were pretreated with R-IPC [15][16][17], although one has failed to do so [18]. In one study on rats, R-IPC was shown to reduce the release of ALT when only the hepatic artery was clamped, but not when the artery as well as the portal vein were clamped [19].…”

Remote ischemic preconditioning prevents lipopolysaccharide-induced liver injury through inhibition of NF-κB activation in mice

“…The protective effect of ischemic preconditioning (IPC) in liver ischemia/reperfusion (I/R) injury is well-known [9]. Peralta et al [10] demonstrated that IPC prevents the release of TNF-a from Kupffer cells during the reperfusion phase following hepatic ischemia.…”

Remote Limb Ischaemic Postconditioning Protects Against Myocardial Ischaemia/Reperfusion Injury in Mice: Activation of JAK/STAT3-Mediated Nrf2-Antioxidant Signalling

“…During the reperfusion period, RIPostC was induced by 3 cycles of 5 min of left femoral artery occlusion with a microvascular clamp under an operating microscope, as previously described [26], and 5 min of reperfusion.…”