Remote Memory in Alzheimer's Disease

Dorrego, María Flavia; Sabe, Liliana; Cuerva, A. García; Kuzis, G.; Tiberti, C.; Boller, François; Starkstein, Sergio E.

doi:10.1176/jnp.11.4.490

Cited by 35 publications

(27 citation statements)

References 16 publications

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“…In contrast, other studies found a TG in AD patients limited to recent periods using tests of famous people [13] or tasks combining famous people and public events [38], pointing to the anterograde amnesia as a plausible explanation for the results. Moreover, completely opposite patterns have also been found in AD when combining famous people and famous public events, whereby better performance was observed for recent rather than for remote periods [14]. Finally, no particular TG was found in a few other studies assessing memory for public events in AD and aMCI [15,18,23,39].…”

Section: Introductionmentioning

confidence: 95%

“…Deficits in semantic memory have been extensively documented in AD using tests of famous people [9][10][11][12][13] and public events [13][14][15][16][17][18][19][20][21][22][23]. Studies have also demonstrated semantic impairment in aMCI using tests requiring the identification of famous people and famous buildings [11,12,[24][25][26][27][28][29], as well as public events [15,24,27,[30][31][32].…”

Section: Introductionmentioning

confidence: 99%

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Memory for Public Events in Mild Cognitive Impairment and Alzheimer’s Disease: The Importance of Rehearsal

Langlois

Joubert

Benoit

et al. 2016

JAD

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Ribot's law refers to the better preservation of remote memories compared with recent ones that presumably characterizes retrograde amnesia. Even if Ribot-type temporal gradient has been extensively studied in retrograde amnesia, particularly in Alzheimer's disease (AD), this pattern has not been consistently found. One explanation for these results may be that rehearsal frequency rather than remoteness accounts for the better preservation of these memories. Thus, the aim of present study was to address this question by studying retrograde semantic memory in subjects with amnestic Mild Cognitive Impairment (aMCI) (n = 20), mild AD (n = 20) and in healthy older controls (HC; n = 19). In order to evaluate the impact of repetition as well as the impact of remoteness, we used a test assessing memory for enduring and transient public events that occurred in the recent and remote past. Results show no clear temporal gradient across time periods (1960-1975; 1976-1990; 1991-2005; 2006-2011), but a better performance was observed in all three groups for enduring compared with transient events. Moreover, although deficits were globally found in both patients groups compared with HC, more specific analyses revealed that aMCI patients were only impaired on transient events while AD patients were impaired on both transient and enduring events. Exploratory analyses also revealed a tendency suggesting preservation of remote transient events in aMCI. These findings are discussed with regards to memory consolidation models.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Memory for Public Events in Mild Cognitive Impairment and Alzheimer’s Disease: The Importance of Rehearsal

Langlois

Joubert

Benoit

et al. 2016

JAD

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“…Similarly, signs of semantic RA have been reported in samples of aMCI and AD patients using tests of famous public events [22][23][24][25][26][27] and tests of famous faces or famous names [28][29][30][31][32]. But also for this type of information mixed results regarding the temporal extent and gradient of RA have been reported [22][23][24][25]. From the above it is clear that, although interest in studying remote memory has grown exponentially over time, behavioral studies in aMCI and AD have produced ambiguous results and disagreement about the specific pattern of RA in these patients remains.…”

Section: Introductionmentioning

confidence: 62%

“…However, conflicting results have been reported about the presence or absence of a Ribot-like temporal gradient, with some authors reporting a significant temporal-graded amnesia in AD and aMCI [14,15,18] and others reporting no differences in memory recall between remote and recent incidents [19][20][21]. Similarly, signs of semantic RA have been reported in samples of aMCI and AD patients using tests of famous public events [22][23][24][25][26][27] and tests of famous faces or famous names [28][29][30][31][32]. But also for this type of information mixed results regarding the temporal extent and gradient of RA have been reported [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Retrograde Amnesia for Episodic and Semantic Memories in Amnestic Mild Cognitive Impairment

Simone

Fadda

Perri

et al. 2017

JAD

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Abstract. Retrograde amnesia (RA), which includes loss of memory for past personal events (autobiographical RA) and for acquired knowledge (semantic RA), has been largely documented in patients with amnestic mild cognitive impairment (aMCI). However, previous studies have produced controversial results particularly concerning the temporal extent of memory impairment. Here we investigated whether, with the onset of hippocampal pathology, age of memory acquisition and retrieval frequency play different roles in modulating the progressive loss of semantic and episodic contents of retrograde memory respectively. For this purpose, aMCI patients and healthy controls were tested for the ability to recall semantic and autobiographical information related to famous public events as a function of both age of acquisition and retrieval frequency. In aMCI patients, we found that the impairment in recollecting past personal incidents was modulated by the combined action of memory age and retrieval frequency, because older and more frequently retrieved episodes are less susceptible to loss than more recent and less frequently retrieved ones. On the other side, we found that the loss of semantic information depended only on memory age, because the remoteness of the trace allows for better preservation of the memory. Our results provide evidence that the loss of the two components of retrograde memory is regulated by different mechanisms. This supports the view that diverse neural mechanisms are involved in episodic and semantic memory trace storage and retrieval, as postulated by the Multiple Trace Theory.

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“…Most studies agree that there is a deficit in this type of memory [37,[51][52][53][54][55][56][57][58], but there is disagreement about the pattern of the deficit: which component is more deteriorated, the episodic or the semantic? Which memories show a greater degree of decline, the recent ones or the remote ones?…”

Section: Autobiographical Memory Decline In the Course Of Alzheimer-tmentioning

confidence: 99%

Behavior and Emotion in Dementia

Rodríguez¹,

Sales²,

RedondoFlores³

et al. 2016

Update on Dementia

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During the course of disease, the patient and caregiver face emotional and behavioral problems that may occur. Therefore, it is important to knowing how emotions and the perception of them are modified and thus to know the impact they have on mood and behavior of the patient and caregiver. Publicizing the type of pathology, both emotional and behavioral levels, in a patient with dementia can help in the development of nonpharmacological interventions that could slow the symptoms and improve the quality of life of patients.

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Remote Memory in Alzheimer's Disease

Cited by 35 publications

References 16 publications

Memory for Public Events in Mild Cognitive Impairment and Alzheimer’s Disease: The Importance of Rehearsal

Memory for Public Events in Mild Cognitive Impairment and Alzheimer’s Disease: The Importance of Rehearsal

Retrograde Amnesia for Episodic and Semantic Memories in Amnestic Mild Cognitive Impairment

Behavior and Emotion in Dementia

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