Remote Reperfusion Lung Injury is Associated With AMP Deaminase 3 Activation and Attenuated by Inosine Monophosphate

Li, Peili; Oginö, Kazuhíde; Hoshikawa, Yasushi; Morisaki, Hiroko; Cheng, Jidong; Toyama, Keiko; Morisaki, Takayuki; Hashimoto, Kiyoshi; Ninomiya, Haruaki; Tomikura-Shimoyama, Yoko; Igawa, Osamu; Shigemasa, Chiaki; Hisatome, Ichiro

doi:10.1253/circj.71.591

Cited by 11 publications

(5 citation statements)

References 23 publications

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“…36 A previous study clearly demonstrated that skeletal muscle ischemia---reperfusion led to remote lung inflammation, which was characterized by increased MPO activity and significant neutrophil infiltration in the lung. 37 NO level is a significant determinant of the lung injury process which is caused by lower extremity ischemia---reperfusion. 38 The effects of melatonin on ischemia---reperfusion injury in an ex vivo rat heart model was studied by Lagneux et al 39 The authors explained that the melatonin significantly reduced infarct size and the incidence of reperfusion arrhythmias.…”

Section: Discussionmentioning

confidence: 99%

Melatonin attenuates lung injury in a hind limb ischemia–reperfusion rat model

Takhtfooladi¹,

Takhtfooladi²,

Moayer³

et al. 2015

Revista Portuguesa de Pneumologia (English Edition)

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Section: Discussionmentioning

confidence: 99%

Melatonin attenuates lung injury in a hind limb ischemia–reperfusion rat model

Takhtfooladi¹,

Takhtfooladi²,

Moayer³

et al. 2015

Revista Portuguesa de Pneumologia (English Edition)

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“…IMP has also been shown to be anti-inflammatory (Qiu et al 2000, Li et al 2007, an effect that may also be mediated through the pathways activated by inosine. Indeed, inhibition of IMP dehydrogenase (IMPDH) by mycophenolate mofetil (MMF) has proved effective in transplant rejection and also in a variety of autoimmune diseases (Allison & Eugui 2000) including type I diabetes , StosicGrujicic et al 2002.…”

Section: Discussionmentioning

confidence: 99%

The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes

Mabley

Pacher

Murthy

et al. 2008

Journal of Endocrinology

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Endogenous purines including inosine have been shown to exert immunomodulatory and anti-inflammatory effects in a variety of disease models. The dosage of inosine required for protection is very high because of the rapid metabolism of inosine in vivo. The aim of this study was to determine whether a metabolic-resistant purine analogue, INO-2002, exerts antiinflammatory effects in two animal models of type I diabetes.

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“…In mice, remote reperfusion lung injury is associated with AMP deaminase 3 activation and attenuation by inosine monophosphate [38], showing that AMPD3 plays a critical role in remote reperfusion lung injury in mice [39]. In this study, the lower AMPD3 expression in DPL pigs compared with their DLY counterparts indicates that the DPL pig lungs were less affected by PRRSV.…”

Section: Discussionmentioning

confidence: 50%

Genome-Wide Gene Expression Profiles in Lung Tissues of Pig Breeds Differing in Resistance to Porcine Reproductive and Respiratory Syndrome Virus

et al. 2014

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Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is an infectious disease characterized by severe reproductive deficiency in pregnant sows, typical respiratory symptoms in piglets, and high mortality rate of piglets. In this study, we employed an Affymetrix microarray chip to compare the gene expression profiles of lung tissue samples from Dapulian (DPL) pigs (a Chinese indigenous pig breed) and Duroc×Landrace×Yorkshire (DLY) pigs after infection with PRRSV. During infection with PRRSV, the DLY pigs exhibited a range of clinical features that typify the disease, whereas the DPL pigs showed only mild signs of the disease. Overall, the DPL group had a lower percentage of CD4+ cells and lower CD4+/CD8+ratios than the DLY group (p<0.05). For both IL-10 and TNF-α, the DLY pigs had significantly higher levels than the DPL pigs (p<0.01). The DLY pigs have lower serum IFN-γ levels than the DPL pigs (p<0.01). The serum IgG levels increased slightly from 0 dpi to 7 dpi, and peaked at 14 dpi (p<0.0001). Microarray data analysis revealed 16 differentially expressed (DE) genes in the lung tissue samples from the DLY and DPL pigs (q≤5%), of which LOC100516029 and LOC100523005 were up-regulated in the PRRSV-infected DPL pigs, while the other 14 genes were down-regulated in the PRRSV-infected DPL pigs compared with the PRRSV-infected DLY pigs. The mRNA expression levels of 10 out of the 16 DE genes were validated by real-time quantitative RT-PCR and their fold change was consistent with the result of microarray data analysis. We further analyzed the mRNA expression level of 8 differentially expressed genes between the DPL and DLY pigs for both uninfected and infected groups, and found that TF and USP18 genes were important in underlying porcine resistance or susceptibility to PRRSV.

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Remote Reperfusion Lung Injury is Associated With AMP Deaminase 3 Activation and Attenuated by Inosine Monophosphate

Cited by 11 publications

References 23 publications

Melatonin attenuates lung injury in a hind limb ischemia–reperfusion rat model

Melatonin attenuates lung injury in a hind limb ischemia–reperfusion rat model

The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes

Genome-Wide Gene Expression Profiles in Lung Tissues of Pig Breeds Differing in Resistance to Porcine Reproductive and Respiratory Syndrome Virus

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