Remotely triggered release of small molecules from LaB6@SiO2-loaded polycaprolactone microneedles

Chen, Mei-Chin; Wang, Kuan Wen; Chen, Dong-Hwang; Ling, Ming Hung; Liu, Chih Ying

doi:10.1016/j.actbio.2014.11.040

Cited by 76 publications

(37 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some NP variants harbour interesting radiation responsive properties that have been used to design infrared triggered drug release MN arrays. Chen et al developed polycaprolactone MN arrays containing silica-coated lanthanum hexaboride nanostructures that acted as a local heat source when the array was irradiated with near-infrared radiation ( 152 , 153 ). After irradiation the temperature reached within the arrays was 50°C ( 152 , 153 ), thus inducing a phase transition on the polycaprolactone, leading to the melting of the needles (Fig.…”

Section: Microneedle-mediated Transdermal Delivery Of Nanoparticles Amentioning

confidence: 99%

See 1 more Smart Citation

Microneedles: A New Frontier in Nanomedicine Delivery

et al. 2016

View full text Add to dashboard Cite

This review aims to concisely chart the development of two individual research fields, namely nanomedicines, with specific emphasis on nanoparticles (NP) and microparticles (MP), and microneedle (MN) technologies, which have, in the recent past, been exploited in combinatorial approaches for the efficient delivery of a variety of medicinal agents across the skin. This is an emerging and exciting area of pharmaceutical sciences research within the remit of transdermal drug delivery and as such will undoubtedly continue to grow with the emergence of new formulation and fabrication methodologies for particles and MN. Firstly, the fundamental aspects of skin architecture and structure are outlined, with particular reference to their influence on NP and MP penetration. Following on from this, a variety of different particles are described, as are the diverse range of MN modalities currently under development. The review concludes by highlighting some of the novel delivery systems which have been described in the literature exploiting these two approaches and directs the reader towards emerging uses for nanomedicines in combination with MN.

show abstract

Section: Microneedle-mediated Transdermal Delivery Of Nanoparticles Amentioning

confidence: 99%

“…This phenomena triggered drug release from the array. Rhodamine 6G was used as a model molecule to ascertain this behaviour ( 152 , 153 ). Furthermore, the system was tested in vivo delivering doxorubicin in a rat model after near-infrared radiation ( 153 ).…”

Section: Microneedle-mediated Transdermal Delivery Of Nanoparticles Amentioning

confidence: 99%

Microneedles: A New Frontier in Nanomedicine Delivery

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Also, various materials can be selected to prepare functionalized microneedles. For example, Chen et al developed a light-activatable polycaprolactone microneedle system to repeatedly trigger small molecular drug release, providing a user-friendly and low toxicity option for patients who need long-term treatment 45 - 47 .…”

Section: Introductionmentioning

confidence: 99%

Dissolving Microneedles with Spatiotemporally controlled pulsatile release Nanosystem for Synergistic Chemo-photothermal Therapy of Melanoma

et al. 2020

View full text Add to dashboard Cite

High aggressiveness and recurrence of melanoma tumors require multiple systemic drug administrations, causing discomfort and severe side effects to the patients. Topical treatment strategies that provide repetitively controllable and precise drug administrations will greatly improve treatment effects. Methods: In this study, a spatiotemporally controlled pulsatile release system, which combined dissolving microneedles (DMNs) and thermal-sensitive solid lipid nanoparticles (SLNs), was constructed to realize multiple doses of dual-modal chemo-photothermal therapy in a single administration. Paclitaxel (PTX) and photothermal agent IR-780 were encapsulated into SLNs and were concentrated in the tips of DMNs (PTX/IR-780 SLNs @DMNs). Equipped with several needles, the DMN patch could be directly inserted into the tumor site and provide a stable “Zone accumulation” to constrain the PTX/IR-780 SLNs at the tumor site with uniform distribution. Results: In vitro experiments showed that after irradiation with near-infrared light, the PTX/IR-780 SLNs gradually underwent phase transition, thereby accelerating the release of PTX. When irradiation was switched off, the PTX/IR-780 SLNs cooled to re-solidify with limited drug release. Compared with intravenous and intratumoral injections, very few SLNs from PTX/IR-780 SLNs @DMNs were distributed into other organs, resulting in enhanced bioavailability at the tumor site and good safety. In vivo analysis revealed that PTX/IR-780 SLNs @DMNs exhibited significant anti-tumor efficacy. In particular, the primary tumor was completely eradicated with a curable rate of 100% in 30 days and the highest survival rate of 66.67% after 100 days of treatment. Conclusion: Herein, we developed a DMN system with a unique spatiotemporally controlled pulsatile release feature that provides a user-friendly and low-toxicity treatment route for patients who need long-term and repeat treatments.

show abstract

“…The results showed that the MN patches with lower height resulted in better mechanical strength. Chen et al 102 fabricated MNs with various types of aspect ratio and the results demonstrated that the MNs with a smaller aspect ratio also exhibited higher mechanical strength. Gittard et al 132 also proved that a decrease in the aspect ratio of MN induced to an increase in mechanical strength.…”

Section: Classification Of Mnsmentioning

confidence: 99%

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

et al. 2019

View full text Add to dashboard Cite

Microneedle (MN) delivery system has been greatly developed to deliver drugs into the skin painlessly, noninvasively, and safety. In the past several decades, various types of MNs have been developed by the newer producing techniques. Briefly, as for the morphologically, MNs can be classified into solid, coated, dissolved, and hollow MN, based on the transdermal drug delivery methods of “poke and patch,” “coat and poke,” “poke and release,” and “poke and flow,” respectively. Microneedles also have other characteristics based on the materials and structures. In addition, various manufacturing techniques have been well-developed based on the materials. In this review, the materials, structures, morphologies, and fabricating methods of MNs are summarized. A separate part of the review is used to illustrate the application of MNs to deliver vaccine, insulin, lidocaine, aspirin, and other drugs. Finally, the review ends up with a perspective on the challenges in research and development of MNs, envisioning the future development of MNs as the next generation of drug delivery system.

show abstract

Remotely triggered release of small molecules from LaB6@SiO2-loaded polycaprolactone microneedles

Cited by 76 publications

References 30 publications

Microneedles: A New Frontier in Nanomedicine Delivery

Microneedles: A New Frontier in Nanomedicine Delivery

Dissolving Microneedles with Spatiotemporally controlled pulsatile release Nanosystem for Synergistic Chemo-photothermal Therapy of Melanoma

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Contact Info

Product

Resources

About