Renal Cell Carcinoma Presenting as an Ampullary Mass: A Case Report and Review of Literature

Hasan, Syed; Khan, Zubair; Khan, Mohammad Saud; Darr, Umar; Javaid, Toseef; Ahmed, R. Baba; Nawras, Ali

doi:10.14740/gr981w

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…Only two of 307 ERCP cases in eight studies involved metastases from renal cell carcinoma. There are isolated reports of MBO from ampullary or bile duct involvement[ 79 , 80 ]. Simultaneous gastric outlet obstruction can rarely occur[ 80 ].…”

Section: Primary Malignanciesmentioning

confidence: 99%

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

Okamoto¹

2022

WJG

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Malignant biliary obstruction generally results from primary malignancies of the pancreatic head, bile duct, gallbladder, liver, and ampulla of Vater. Metastatic lesions from other primaries to these organs or nearby lymph nodes are rarer causes of biliary obstruction. The most common primaries include renal cancer, lung cancer, gastric cancer, colorectal cancer, breast cancer, lymphoma, and melanoma. They may be difficult to differentiate from primary hepato-pancreato-biliary cancer based on imaging studies, or even on biopsy. There is also no consensus on the optimal method of treatment, including the feasibility and effectiveness of endoscopic intervention or surgery. A thorough review of the literature on pancreato-biliary metastases and malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer is presented. The diagnostic modality and clinical characteristics may differ significantly depending on the type of primary cancer. Different primaries also cause malignant biliary obstruction in different ways, including direct invasion, pancreatic or biliary metastasis, hilar lymph node metastasis, liver metastasis, and peritoneal carcinomatosis. Metastasectomy may hold promise for some types of pancreato-biliary metastases. This review aims to elucidate the current knowledge in this area, which has received sparse attention in the past. The aging population, advances in diagnostic imaging, and improved treatment options may lead to an increase in these rare occurrences going forward.

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Section: Primary Malignanciesmentioning

confidence: 99%

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

Okamoto¹

2022

WJG

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Metastatic renal cell carcinoma presenting as gastrointestinal bleeding

Nario,

Househ,

Al‐Sohaily

2024

JGH Open

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A 73‐year‐old female with metastatic renal cell carcinoma (RCC) presented with melena and lethargy. She was found to be iron deficient with a hemoglobin of 101 g/L. Her gastroscopy found six irregular pedunculated non‐bleeding polyps, 10–20 mm in diameter. Histopathology of the resected polyp returned as metastatic clear cell renal cell carcinoma. Gastric metastases from any primary malignancy are rare and metastatic RCC accounts for only 7% of these tumors. Furthermore, while RCC commonly metastasises to the lung, bone and lymph nodes, metastasis to the gastrointestinal tract is extremely rare, occurring in <1% of patients. Presentation of RCC as a gastric polyp is usually a late event, and on average occurs 6.7 years after initial diagnosis of RCC. Therefore, this case highlights a rare but important late complication of RCC, presenting as gastrointestinal bleeding secondary to gastric metastases.

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Cancer-Associated Fibroblasts Boost Tumorigenesis of Clear Cell Renal Cell Carcinoma via Exosome-Mediated Paracrine SNHG1

Tian,

Wei,

et al. 2023

Biochem Genet

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Renal Cell Carcinoma Presenting as an Ampullary Mass: A Case Report and Review of Literature

Cited by 3 publications

References 20 publications

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

Metastatic renal cell carcinoma presenting as gastrointestinal bleeding

Cancer-Associated Fibroblasts Boost Tumorigenesis of Clear Cell Renal Cell Carcinoma via Exosome-Mediated Paracrine SNHG1

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