Renal-clearable nanoprobes for optical imaging and early diagnosis of diseases

An, Wei; Xu, Weiping; Zhou, Ya; Huang, Changwen; Huang, Weiguo; Huang, Jiaguo

doi:10.1039/d3bm01776a

Biomater. Sci.

2024

DOI: 10.1039/d3bm01776a

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Renal-clearable nanoprobes for optical imaging and early diagnosis of diseases

Wei An,

Weiping Xu,

Ya Zhou

et al.

Abstract: Optical imaging has played an indispensable role in clinical diagnostics and fundamental biomedical research due to the high sensitivity, high spatiotemporal resolution, cost-effectiveness, and easy accessibility. However, the issue of...

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Cited by 2 publications

References 67 publications

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Sun,

Tan

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Biosensors and Bioelectronics

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A water-soluble aggregation-induced emission luminogen for NIR-I/NIR-II fluorescence imaging of breast cancer bone metastases

Yan,

Sun,

Tan

et al. 2025

Biosensors and Bioelectronics

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Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

Lima,

Justo,

Sousa

2024

Beilstein J. Nanotechnol.

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Ultrasmall nanoparticles (usNPs) have emerged as promising theranostic tools in cancer nanomedicine. With sizes comparable to globular proteins, usNPs exhibit unique physicochemical properties and physiological behavior distinct from larger particles, including lack of protein corona formation, efficient renal clearance, and reduced recognition and sequestration by the reticuloendothelial system. In cancer treatment, usNPs demonstrate favorable tumor penetration and intratumoral diffusion. Active targeting strategies, incorporating ligands for specific tumor receptor binding, serve to further enhance usNP tumor selectivity and therapeutic performance. Numerous preclinical studies have already demonstrated the potential of actively targeted usNPs, revealing increased tumor accumulation and retention compared to non-targeted counterparts. In this review, we explore actively targeted inorganic usNPs, highlighting their biological properties and behavior, along with applications in both preclinical and clinical settings.

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Renal-clearable nanoprobes for optical imaging and early diagnosis of diseases

Abstract: Optical imaging has played an indispensable role in clinical diagnostics and fundamental biomedical research due to the high sensitivity, high spatiotemporal resolution, cost-effectiveness, and easy accessibility. However, the issue of...

Cited by 2 publications

References 67 publications

A water-soluble aggregation-induced emission luminogen for NIR-I/NIR-II fluorescence imaging of breast cancer bone metastases

A water-soluble aggregation-induced emission luminogen for NIR-I/NIR-II fluorescence imaging of breast cancer bone metastases

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

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