Renal Doppler Sonography As A Non-Invasive Technique For Early Detection Of Sickle Nephropathy In Children

Abstract

Objective: Early identification of sickle nephropathy via renal doppler sonography among sickle cell disease patients so as to help in early diagnosis and interventions to prevent progression to end-stage renal disease. Methods: 45 SCD children were included along with 45 healthy control children. Renal doppler sonography (PI and RI) was performed to all subjects. Doppler indices (Resistance Index and pulsatility index) were of value to assess reno-vascular changes in SCD. Laboratory investigations were done: Hb electrophoresis, complete blood picture with blood indices, reticulocytic count, liver enzymes (ALT and AST), HCV serology, serum ferritin and lactate dehydrogenese (LDH). Results: The study group consisted of 45 SCD patients, 27 (60%) males with mean age 12 years (± 3 years). By performing renal doppler sonography, it was found that all study group had significantly higher doppler indices (Resistivity index and pulsatility index) compared to the control group. Results of renal doppler sonography revealed, Main renal pulsatility index was positively correlated with main renal resistance index (r=0.454, p=0.002). Conclusion: Roc curve showed that Main Renal Artery Pulsatility index and resistance index index could act as a predictor for sickle cell nephropathy with high sensitivity values. Otherwise, renal doppler indices didn’t show statistically significant correlation with the other studied variables.