Renal failure as a suspected adverse reaction to benoxaprofen

Abstract

Summary A 77-year-old woman suffering from osteoarthritis was treated with benoxaprofen. She developed diarrhoea, skin rash and renal failure. Renal failure has not been reported before as an adverse reaction to benoxaprofen. The case is discussed in the context of multisystem and immunological response to benoxaprofen.

Diclofenac-Associated Acute Renal Failure

“…Oliguric and nonoliguric acute renal failure events showing morphological pictures of acute interstitial nephritis, with or without skin rash, blood eosinophilia, and/or urine eosinophilia, have been observed following treatment with diflunisal [10], indomethacin [11], tolmetin [12], zomepirac [13], phenylbutazone [14], benoxaprofen [15], and piroxicam [16]. The association of acute renal failure and nephrotic syndrome showing on biopsy speci mens acute interstitial nephritis and minimal glomerular changes has been finally related to fenoprofen [17], na proxen [17], phenylbutazone [18], and indomethacin [19].…”

Oliguric Renal Failure Associated with Benoxaprofen

“…Fatal cases of cholestatic jaundice and renal failure were among these reactions, predominantly affecting elderly patients [1][2][3]. In none of these cases was renal failure attributed to a tubulo-interstitial nephritis.…”