Renal failure secondary to leukemic infiltration of the kidneys

Lundberg, Walter B.; Cadman, E.D.; Finch, Stuart C.; Capizzi, Robert L.

doi:10.1016/0002-9343(77)90427-2

Cited by 40 publications

(21 citation statements)

References 31 publications

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“…In renal failure secondary to documented renal leukemic infiltration, renal enlargement on ultrasound or computed tomography is commonly encountered. [30][31][32] In our patient, an abdominal CT showed no evidence of nephromegaly, hydronephrosis or urinary tract obstruction, therefore, eliminating post-renal or leukemic infiltration as potential causes of his ARF.…”

Section: Discussionsupporting

confidence: 44%

Spontaneous tumor lysis syndrome in acute myeloid leukemia: Two cases and a review of the literature

Riccio¹,

Mato²,

Olson³

et al. 2006

Cancer Biology & Therapy

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KEy wORdSspontaneous tumor lysis syndrome, acute spontaneous tumor lysis syndrome, urate nephropathy, tumor lysis syndrome, acute myeloid leukemia, acute renal failure, hyperuricemia ABStRActSpontaneous tumor lysis syndrome (TLS) is a constellation of electrolyte abnormalities and acute renal failure, which occurs in the setting of rapid cell turnover prior to the administration of cytotoxic chemotherapy. While spontaneous TLS is well described in patients with Burkitt's lymphoma, it is thought to occur less commonly in other hematologic malignancies. We present two cases of spontaneous TLS in patients with newly diagnosed acute myeloid leukemia (AML) followed by a review of the literature in this field.

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Section: Discussionsupporting

confidence: 44%

Spontaneous tumor lysis syndrome in acute myeloid leukemia: Two cases and a review of the literature

Riccio¹,

Mato²,

Olson³

et al. 2006

Cancer Biology & Therapy

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“…We did not analyze the characteristics of the lymphocytes in detail, so it is unknown whether they were CLL cells or normal activated lymphocytes. In general, at autopsy of patients with leukemia, the frequency of direct invasion of the kidney is 50-60% [13]. However, infiltration is restricted to the interstitial region as in the present case, so the glomeruli are not involved [14].…”

Section: Improve Present Casementioning

confidence: 47%

Membranous Glomerulonephritis with Nephrotic Syndrome Associated with Chronic Lymphocytic Leukemia

et al. 2000

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A 66-year-old woman was admitted to our hospital for evaluation of edema of the extremities. Laboratory findings suggested that she had nephrotic syndrome and chronic lymphocytic leukemia (CLL). Renal biopsy (with PAM staining) showed a spike formation in the capillary wall. Immunofluorescent staining revealed deposition of immunoglobulin G (IgG) and the third component of complement in the glomerular basement membrane. Electron microscopy showed fibrillary deposits in the subepithelium. These findings indicated membranous glomerulonephritis (MGN). In addition, focal segmental sclerosis and interstitial lymphocytic infiltration were observed in the renal biopsy specimen. In CLL patients nephrotic syndrome occurs rarely. Even if the complication occurs, MGN is not frequent. Both diseases are suspected to occur in association with each other, and immunologic abnormality contributes to their coexistence. Although administration of prednisolone and endoxan improved leukocytosis, proteinuria was not sufficiently improved with combination therapy.

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“…Physical examination reveals a palpable abdominal mass in 3%-5% of patients. 7 Multiple reports suggest that enlarged kidneys due to leukemic infiltration, detected by USG, CT, or excretory urography, is the most common imaging manifestation observed in renal involvement of ALL. 1 Olgar et al showed that renal leukemic infiltration is a risk-factor for developing hypertension, and they also determined that hypertension might be a risk factor for renal parenchymal disease.…”

Section: Discussionmentioning

confidence: 99%

Uncontrolled hypertension secondary to leukemic cell infiltration of kidneys in a hemodialysis patient

Türkmen

Altıntepe²,

Güney³

et al. 2010

IJNRD

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Leukemic infiltration of the kidney is usually silent, and the admission of the patients with renal dysfunction or acute kidney injury is uncommon. We present a 34-year old hemodialysis patient with new onset of uncontrolled hypertension, erythropoietin-resistant anemia, thrombocytopenia, and Bell's palsy. On admission, his blood pressure (BP) was 210/110 mmHg and he had petechiae and purpura at upper and lower extremities. Renal ultrasonography (USG) showed bilaterally enlarged kidneys without hydronephrosis, unlike his previous USG, which determined bilaterally atrophic kidneys. Acute lymphoblastic leukemia, hypertensive crisis due to bilateral leukemic cell infiltration of kidneys, tumor lysis syndrome, and leukemic involvement of the facial nerve were diagnosed. Despite intense antihypertensive management, his BP was not controlled. After prednisolone, daunorubicine, and vincristine therapy, the size of kidneys diminished and his BP dropped under normal range. In conclusion, pathological findings such as uncontrolled hypertension, flank pain, skin rashes, and abnormal blood count should be considered carefully, even in patients with end-stage renal disease receiving renal replacement therapy.

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Renal failure secondary to leukemic infiltration of the kidneys

Cited by 40 publications

References 31 publications

Spontaneous tumor lysis syndrome in acute myeloid leukemia: Two cases and a review of the literature

Spontaneous tumor lysis syndrome in acute myeloid leukemia: Two cases and a review of the literature

Membranous Glomerulonephritis with Nephrotic Syndrome Associated with Chronic Lymphocytic Leukemia

Uncontrolled hypertension secondary to leukemic cell infiltration of kidneys in a hemodialysis patient

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