Renal function after ifosfamide, carboplatin and etoposide (ICE) chemotherapy, nephrectomy and radiotherapy in children with wilms tumour

Daw, Najat C.; Gregornik, David; Rodman, John H.; Marina, Neyssa; Wu, Jianrong; Kun, Larry E.; Jenkins, Jesse J.; McPherson, Valerie; Wilimas, Judith A.; Jones, Deborah

doi:10.1016/j.ejca.2008.09.017

Cited by 40 publications

(32 citation statements)

References 42 publications

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“…Renal toxicity risk assessment after treatment for Wilms' tumor has also been carried out by other authors [9,10]. Data reported in the literature indicate the need for special supervision of the remaining single kidney function.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Renal Function in Pediatric Patients After Treatment for Wilms’ Tumor

2015

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Background. Wilms' tumor is the most common kidney cancer in children. Treatment consists of pre-and post-operative chemotherapy, surgery and in some cases radiotherapy. The treatment of nephroblastomas is very effective. Hence, the population of adult patients cured of this cancer in their childhood is steadily growing, generating a need for longterm health assessment, including renal function, due to the specifications of the therapy and the location of the tumor. Objectives. The aim of the study was to evaluate nephrological complications after treatment for nephroblastoma. Material and Methods. The study group consisted of 50 children treated in the Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation at Wroclaw Medical University (Poland) from 2002 to 2012. An analysis of the patients' medical histories was carried out. The glomerular filtration rate estimated by the Schwartz formula (GFR by Schwartz), serum creatinine levels, urea and electrolyte concentrations; the results of urinalysis and blood pressure were assessed. Each of these analyses was performed at the time of diagnosis, at the end of therapy, as well as 6 months, one year and two years after its completion. Results. The study showed that, in most cases, implemented therapy had no significant impact on the deterioration of renal parameters in the two-year period following treatment for Wilms' tumor. However, the group of patients treated with cyclophosphamide and carboplatin required more careful monitoring, due to a higher risk of renal function deterioration. Conclusions. The study shows that the problem of nephrotoxicity after treatment for Wilms' tumor is more frequent than indicated in other studies; however, the deterioration of kidney function in most cases is not serious. Additional attention should be paid to patients treated with cyclophosphamide and carboplatin. Assessment of the early and late effects of the treatment is a key element in improving the quality of the patients' life (Adv Clin Exp Med 2015, 24, 3, 497-504).

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Section: Discussionmentioning

confidence: 99%

Evaluation of Renal Function in Pediatric Patients After Treatment for Wilms’ Tumor

2015

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“…Nephrectomy was the leading cause of GFR impairment (average 38% reduction vs. 7% reduction after two cycles of ICE chemotherapy). Increased beta-microglobulin secretion without clinically overt dysfunction of the renal tubules was also present [66].…”

Section: Nephrotoxicity Of Platinum Derivatives In Wilms Tumour Patientsmentioning

confidence: 99%

Nephrotoxicity of platinum derivatives in children – a review of the literature

Stefanowicz¹,

Owczuk²,

Iżycka‐Świeszewska³

et al. 2011

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“…Signs of kidney damage may indicate the risk of deterioration of kidney function in the future. Long-term monitoring of renal function in WTS will facilitate the identification of those with treatmentrelated impairment of function.WTS are at risk of deterioration of renal function and CKD because of the following: decreased number of nephrons -after nephrectomy, nephrotoxic side effects of chemotherapy (carboplatin, cisplatin, ifosfamide, cyclophosphamide) or radiation therapy -if solitary kidney was in the field of radiation (3,4,26,27). According to Daw et al (3), the most severe reduction in GFR, measured by 99Tc-DTPA (technetium-99m-diethylenetriamine pentaacetic acid) clearance, occurs after nephrectomy.…”

Section: Chronic Kidney Disease In Wtsmentioning

confidence: 99%

“…The number of survivors who have completed this treatment is increasing. All treatments can have potential long-term influence on the renal function of WT survivors (WTS) (2)(3)(4). A wide range of defects in kidney structure and function, from end-stage renal disease (ESRD) to varying degrees of chronic kidney disease (CKD), have been reported.…”

Section: Introductionmentioning

confidence: 99%

Chronic Kidney Disease in Wilms Tumour Survivors – What Do We Know Today?

Stefanowicz

Kosiak

et al. 2016

Wilms Tumor

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Licence: This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Users are allowed to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material for any purpose, even commercially), as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. AbstractCurrently, the treatment of Wilms tumour (WT) is successful in approximately 90% of cases, and consists of chemotherapy, nephrectomy, and, in some cases, radiation therapy. All treatments have potential long-term influence on the function of solitary kidneys in WT survivors (WTS). Severe reduction in glomerular filtration rate occurs after nephrectomy. All patients who underwent surgical treatment for WT could be considered to have 132a risk of chronic kidney disease (CKD) because they lack a kidney. End-stage renal disease is rare (1.8% of National Wilms Tumour Study patients). Recent studies have revealed that patients with CKD have a greater risk of cardiovascular events and death. Most of the WTS have lower stages or no CKD. Regular biochemical studies and ultrasound examination at follow-up visits should be considered as indispensible elements of long-term care in uninephrectomized WTS. The evaluation of a single kidney function should be frequent, consisting of the assessment of estimated glomerular filtration rate (eGFR), assessment of albumin urine excretion, urine sediment analysis to detect abnormalities, ultrasound examination and measurements of blood pressure. According to Kidney Disease Improving Global Outcomes (KDIGO) recommendation and suggestions, GFR should be assessed using GFR-estimating equations that include serum creatinine and cystatin C concentrations. Cystatin C can be a more sensitive marker of kidney filtration function than creatinine, especially in diseases characterized by a mild decrease in glomerular filtration. This will facilitate the detection of early kidney impairment and assessment of the progression of CKD in WTS.

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Renal function after ifosfamide, carboplatin and etoposide (ICE) chemotherapy, nephrectomy and radiotherapy in children with wilms tumour

Cited by 40 publications

References 42 publications

Evaluation of Renal Function in Pediatric Patients After Treatment for Wilms’ Tumor

Evaluation of Renal Function in Pediatric Patients After Treatment for Wilms’ Tumor

Nephrotoxicity of platinum derivatives in children – a review of the literature

Chronic Kidney Disease in Wilms Tumour Survivors – What Do We Know Today?

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