Renal Function Underpins the Cyclooxygenase-2: Asymmetric Dimethylarginine Axis in Mouse and Man

Ferreira, Plinio; Vaja, Ricky; Lopes-Pires, Maria Elisa; Crescente, Marilena; He, Ya‐Ling; Nüsing, Rolf M.; Liu, Bin; Zhou, Yingbi; Yaqoob, Magdi; Zhang, Anran; Rickman, Matthew; Longhurst, Hilary; White, William E.; Knowles, Rebecca; Chan, Melissa; Warner, Timothy D.; Want, Elizabeth J.; Kirkby, Nicholas S.; Mitchell, Jane A.

doi:10.1016/j.ekir.2023.03.014

Cited by 2 publications

(3 citation statements)

References 51 publications

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“…In particular, the plasma levels of creatinine, SDMA, urea, and ADMA, which are markers of renal dysfunction were suppressed by daily ERGO intake (Fig. 4a-d) [27][28][29]. This finding may be compatible with the previous reports indicating that ERGO modulates oxidative damage of the kidney in rats and that decreased ERGO levels may contribute to chronic kidney disease progression implying beneficial roles of ERGO in the kidney [80,81].…”

Section: Discussionsupporting

confidence: 89%

“…The bar graph data represent mean ± SEM. CXCL9, chemokine (CXC motif) ligand 9; SIRT6, NAD + -dependent protein deacetylase sirtuin-6; TBARS, thiobarbituric acid-reactive substances may also be a marker of endothelial damage [27][28][29]. The levels of these markers in the control group increased significantly between 28 and 92 weeks (P < 0.01; Fig.…”

Section: Ergo Improved Bms In Plasmamentioning

confidence: 92%

“…Cellular senescence and oxidative stress were assessed by western blotting (WB) and ELISA for representative markers (liver p16, SIRT6, TBARS, and plasma CXCL9) [1,[24][25][26]. Systemic senescence was evaluated by CE-MS for renal function, strongly associated with aging and inflammaging markers (creatinine, urea, ADMA, SDMA, quinolinic acid, kynurenine, and tryptophan) [27][28][29][30]. Cognitive impairment was determined using the novel object recognition test (NORT), a commonly used behavioral assay for investigating various aspects of learning and memory in mice [31].…”

Section: Incucyte-based Caenorhabditis Elegans Life and Non-frailty S...mentioning

confidence: 99%

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Ergothioneine promotes longevity and healthy aging in male mice

Katsube,

Ishimoto,

Fukushima

et al. 2024

GeroScience

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Healthy aging has emerged as a crucial issue with the increase in the geriatric population worldwide. Food-derived sulfur-containing amino acid ergothioneine (ERGO) is a potential dietary supplement, which exhibits various beneficial effects in experimental animals although the preventive effects of ERGO on aging and/or age-related impairments such as frailty and cognitive impairment are unclear. We investigated the effects of daily oral supplementation of ERGO dissolved in drinking water on lifespan, frailty, and cognitive impairment in male mice from 7 weeks of age to the end of their lives. Ingestion of 4 ~ 5 mg/kg/day of ERGO remarkably extended the lifespan of male mice. The longevity effect of ERGO was further supported by increase in life and non-frailty spans of Caenorhabditis elegans in the presence of ERGO. Compared with the control group, the ERGO group showed significantly lower age-related declines in weight, fat mass, and average and maximum movement velocities at 88 weeks of age. This was compatible with dramatical suppression by ERGO of the age-related increments in plasma biomarkers (BMs) such as the chemokine ligand 9, creatinine, symmetric dimethylarginine, urea, asymmetric dimethylarginine, quinolinic acid, and kynurenine. The oral intake of ERGO also rescued age-related impairments in learning and memory ability, which might be associated with suppression of the age-related decline in hippocampal neurogenesis and TDP43 protein aggregation and promotion of microglial shift to the M2 phenotype by ERGO ingestion. Ingestion of ERGO may promote longevity and healthy aging in male mice, possibly through multiple biological mechanisms.

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