2022
DOI: 10.1371/journal.pone.0269792
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Renal functional, transcriptome, and methylome adaptations in pregnant Sprague Dawley and Brown Norway rats

Abstract: Pregnancy induces maternal renal adaptations that include increased glomerular filtration rate and renal blood flow which can be compromised in obstetrical complications such as preeclampsia. Brown Norway (BN) rat pregnancies are characterized by placental insufficiency, maternal hypertension, and proteinuria. We hypothesized that BN pregnancies would show renal functional, anatomical, or molecular features of preeclampsia. We used the Sprague-Dawley (CD) rat as a model of normal pregnancy. Pregnancy increased… Show more

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