Renal growth slope in children with congenital and acquired solitary functioning kidneys

Abstract

Purpose: This study aimed to analyze the renal growth slope in children with congenital and acquired solitary functioning kidneys. Methods: This retrospective study included all renal ultrasonography examinations performed in children in the agenesis, multicystic dysplastic kidney (MCDK), or nephrectomy group between September 2002 and February 2019. We reviewed the images and recorded the contralateral kidney size only when there was no focal lesion. Linear mixed model or piecewise linear mixed model analyses with a time point of 24 months of age were performed. Results: There were 132 patients, including 26 patients in the agenesis group, 35 in the MCDK group, and 71 in the nephrectomy group. The nephrectomy group showed the largest baseline kidney size (7.4 cm vs. 5.3 cm in the agenesis group [P<0.001] and 5.2 cm in the MCDK group [P<0.001]) and the smallest overall growth slope (0.04 cm/mo vs. 0.06 cm/mo in the agenesis group [P=0.004] and 0.07 cm/mo in the MCDK group [P<0.001]). However, considering the time point of 24 months for reaching adult renal function, there were significant changes in slope, from 0.1 cm/mo before 24 months of age to 0.03 cm/mo after 24 months of age in all three groups (P<0.001), without a significant difference among the groups. Conclusion: Significant changes were found in the renal growth slope before and after 24 months of age, with no significant difference between congenital and acquired solitary functioning kidneys.

Follow up of renal outcomes in children with solitary kidney

“…The minimum eGFR was determined as 71 mL/min/1.73 m 2 . In previous studies, the rate of reduced eGFR in patients with SK was reported as 8.4%, 4 1.3%, 10 and 10.6% 20 . Abou Jaoude et al detected higher eGFR in patients with CSK compared to the ASK group and noted the presence of a negative correlation between eGFR and both age and follow‐up time 17 .…”

“…In previous studies, the rate of reduced eGFR in patients with SK was reported as 8.4%, 4 1.3%, 10 and 10.6%. 20 Abou Jaoude et al detected higher eGFR in patients with CSK compared to the ASK group and noted the presence of a negative correlation between eGFR and both age and follow-up time. 17 We also observed that the children with CSK had significantly higher eGFR than those with ASK (p < 0.001); however, we did not detect a correlation between eGFR and age or follow-up time.…”