Renal Impairment and Its Reversibility Following Variable Periods of Complete Ureteric Obstruction

Fink, Rok; Caridis, D. T.; Chmiel, R. L.; Ryan, Graeme B.

doi:10.1111/j.1445-2197.1980.tb04502.x

Cited by 68 publications

(51 citation statements)

References 9 publications

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“…Vaughan and Gillenwater [22] indicated that the duration of obstruction is very important in predicting recovery of RF, with only partial recovery to be expected when the obstruction is present for more than 2 weeks in dogs. Two other animal model studies have yielded similar results [23,24]. In 1975, Mayor and co-workers found an advantage in early correction of obstruction, stating that if obstruction was relieved between 1 and 2 years of age, RF improved much less than in children operated on at a younger age.…”

Section: Discussionsupporting

confidence: 52%

Ureteropelvic junction obstruction in children: 10 years’ experience in one institution

et al. 2006

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We reviewed our experience over 10 years with pyeloplasty for ureteropelvic junction obstruction. Preoperative and postoperative isotope renal scans were performed to assess the surgical outcome, with particular emphasis on the postoperative change in renal function (RF). We retrospectively reviewed the medical records of 137 consecutive children with ureteropelvic obstruction operated between January 1994 and December 2003. A total of 109 kidneys in 102 patients were evaluated with renal echo and (99m)Tc-diethylenetriaminepentaacetic renography both before and after Anderson-Hynes dismembered pyeloplasty. The improvement of RF >5% was noted in 67 kidneys (61.5%), the function remained stable in 30 kidneys (27.5%), and it deteriorated (>5%) in 12 kidneys (11.0%). Five patients (4.6%) required repeat pyeloplasty for either prolonged urine leakage or reobstruction with deterioration in RF. Dismembered pyeloplasty in children with ureteropelvic junction obstruction is safe. The renal functional improvement can be expected in the majority of kidneys that have impaired function at presentation.

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Section: Discussionsupporting

confidence: 52%

Ureteropelvic junction obstruction in children: 10 years’ experience in one institution

et al. 2006

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“…Hinman and Morison [1926] showed in dogs and rats that no repair will take place in a severely damaged hydronephrotic kidney after release of obstruction provided that the contralateral kidney has a normal function. Furthermore, the function of the hydronephrotic kidney shows a dramatic improvement when the contralateral kidney is removed [Fink et al, 1980]. Recently, it was hypothesized that when renal function decreases in the hydronephrotic kidney due to ongoing obstruction, the contralateral non-obstructed kidney is stimulated to grow at a fast rate.…”

Section: Compensatory Growth In the Contralateralmentioning

confidence: 98%

“…A progressive loss of functional recovery has been reported with increasing periods of obstruction. In dogs, a nearly complete return of function follows correction, after 4 days of obstruction [Fink et al, 1980]. After 14 days of obstruction, the GFR and tubular function returned to 46% of the control levels by 4 months after relief of obstruction, and no changes were seen thereafter [Vaughan et al, 1971].…”

Section: Duration Of Obstructionmentioning

confidence: 98%

Partial unilateral ureteral obstruction in rats

Wen

2002

Neurourology and Urodynamics

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This review comprises an overview of the current knowledge on experimental partial unilateral ureteral obstruction (PUUO) and a summary of our latest original experimental PUUO studies in rats. Neonatal PUUO is the type of obstruction that is most often encountered in pediatric clinical practice. However, the pathogenesis of PUUO is still incompletely understood. Most of our knowledge on PUUO has been derived from experimental studies in a variety of animal models. Although progress has been made, the natural history of congenital hydronephrosis is still incompletely described. The effects on kidney functions of long-term urinary tract obstruction, especially PUUO, have been less intensively studied. Recently, we created models with mild and severe PUUO in young rats by embedding the upper one fourth or the upper two thirds of the left ureter into the psoas muscle, respectively. Thereafter, the technique was used to create mild and severe PUUO in newborn rats and magnetic resonance imaging studies showed that both mild and severe obstruction caused a time-dependent decrease in renal blood flow. Compensatory increase in total kidney volume and renal vein blood flow in contralateral non-obstructed kidneys was not detectable when functional deterioration in the partially obstructed kidneys was present. Finally, we investigated the dynamic changes in renal relative signal intensity (RSI) of gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) using magnetic resonance imaging in rats with partial, complete unilateral ureteral obstruction and sham-operated controls. The results showed that changes in Gd-DTPA RSI are compatible with the known physiological and anatomical changes in kidneys in response to ureteral obstruction and useful for distinguishing an obstructed from a non-obstructed collecting system and also for differentiating a partially obstructed from a completely obstructed collecting system.

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“…Healthy dogs subjected to 1 week of ureteral obstruction recover 65% of the baseline glomerular filtration rate (GFR) and recovery plateaus after a period of 5 weeks [5]. After 2 weeks of ureteral obstruction, GFR returns to 46% over a period of 4 months [6,7].…”

Section: Introductionmentioning

confidence: 99%