Renal involvement in active `juvenile' cirrhosis

Abstract

SYNOPSIS Twelve patients with active 'juvenile' cirrhosis (active chronic hepatitis, 'lupoid' hepatitis) and six subjects with other types of portal or postnecrotic cirrhosis were submitted to percutaneous renal biopsy. In addition, renal function was assessed in all patients by measurement of the 24-hour endogenous creatinine clearance, maximal urinary osmolality after deprivation of water, 24-hour urinary protein excretion, and routine urine analysis.Renal function was not significantly abnormal in either group of patients, but seven of the 12 patients with active 'juvenile' cirrhosis showed mild histological changes on renal biopsy. These changes are very similar to the lesions described in early 'lupus nephritis'.The significance of these findings in relation to the aetiology of active 'juvenile' cirrhosis is discussed.In recent years a newly recognized syndrome affecting the liver has attracted increasing attention. Since the first description of the syndrome (Waldenstr6m, 1950), a number of cases have been reported

Autoimmune hepatitis with membranous glomerulonephritis

“…Penner 5 has reported that two of 18 AIH patients were complicated with membranous glomerulonephritis accompanied by nodular deposits of immunoglobulins and complements on their glomeruli. Silva et al 6 reported in their study of 12 cases of lupoid hepatitis that seven patients showed mild renal histologic changes very similar to early lupus nephritis, although the findings of renal function tests and urine analysis were not significantly abnormal. Tsurui et al 7 have also reported a case of AIH associated with glomerulonephritis with granular deposits of C1q.…”

Chronic active hepatitis, pyoderma gangrenosum and febrile panniculitis

“…Autoantibody‐positive chronic active hepatitis is well known to be associated with a wide variety of systemic disease 1 . Numerous pulmonary endocrine, haematological, renal and neurological manifestations are recognised 2‐4 .…”