Renal Involvement in Patients with Hepatosplenic Schistosomiasis Mansoni *

Rocha, Heonir; Cruz, Thomaz; Brito, Edilson; Susin, Myron

doi:10.4269/ajtmh.1976.25.108

Cited by 42 publications

(12 citation statements)

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“…Patients with chronic S. mansoni infection involving portal hypertension and an enlarged spleen (hepatosplenic schistosomiasis) have an increased frequency (15%) of renal disease; this infection is clinically characterized by variable proteinuria ranging from asymptomatic to nephrotic syndrome (4,10,61). The pathological changes vary.…”

Section: Schistosoma Mansonimentioning

confidence: 99%

Glomerulopathy Associated with Parasitic Infections

Velthuysen¹,

Florquin²

2000

Clinical Microbiology Reviews

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Section: Schistosoma Mansonimentioning

confidence: 99%

Glomerulopathy Associated with Parasitic Infections

Velthuysen¹,

Florquin²

2000

Clinical Microbiology Reviews

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“…Studies in Brazil show that up to 15% of patients with hepatosplenic schistosomiasis also present renal disease [6][7][8][9][10][11][12][13][14] . In Egypt, Barsoum 15,16 reported that in 10% of patients on chronic hemodialysis, schistosomiasis was the primary cause of their renal failure.…”

Section: Introductionmentioning

confidence: 99%

Glomerulonephritis in schistosomiasis mansoni: a time to reappraise

Rodrigues

Otoni

Voieta

et al. 2010

Rev. Soc. Bras. Med. Trop.

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Introduction:The current prevalence of glomerulonephritis in patients with hepatosplenic schistosomiasis mansoni in Brazil was evaluated. Methods: Sixty three patients (mean age 45.5±11 years) attending the outpatient infectious disease clinic of a University Hospital in Belo Horizonte, Brazil, from 2007 to 2009, were consecutively examined and enrolled in the present investigation. Diagnosis of hepatosplenic schistosomiasis was based on epidemiological, clinical and parasitological data and imaging techniques. Eight patients, who presented >30mg/day albuminuria, were submitted to percutaneous ultrasound guided renal biopsy. Kidney tissue fragments were examined under light, direct immunofluorescence and electron microscopy. Results: All patients showed mesangial enlargement. In five, mesangial hypercellularity was observed and four presented duplication of the glomerular basement membrane. Areas of glomerular sclerosis were diagnosed in four. Deposits of immunoglobulin M and C3 were present in six samples; deposits of IgG in four, IgA in three and C1q in two samples. In all patients, immunoglobulin A was reported in the lumen of renal tubules. Deposits of kappa and lambda were observed in six samples. Electron microscopy revealed dense deposits in the glomerular tissue of three patients. Arterial hypertension, small esophageal varices, slight increases in serum creatinine and decreases in serum albumin were associated with glomerular disease. Conclusions: Renal disease associated with hepatosplenic schistosomiasis was verified in 12.7% of patients and type I membranoproliferative glomerulonephritis was observed in 50% of them. Schistosomal glomerulopathy still is an important problem in patients with hepatosplenic schistosomiasis in Brazil.

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“…Class II (exudative glomerulonephritis) occurs in the presence of concomitant infection by Schistosoma and Salmonella species. Patients may have nephrotic or nephritic syndrome and a proliferative glomerulonephritis with neutrophil infiltration of the glomeruli (Bassily et al 1976, Rocha et al 1976, Martinelli et al 1992. Class III (membranoproliferative glomerulonephritis) and Class IV (focal segmental glomerulosclerosis) represent the patterns of glomerular lesion that are most consistently associated with the hepatosplenic form of schistosomiasis in Brazil.…”

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confidence: 99%