Renal Oxygenation Changes during Acute Unilateral Ureteral Obstruction: Assessment with Blood Oxygen Level–Dependent MR Imaging—Initial Experience

Thoeny, Harriet C.; Kessler, Thomas M.; Simon-Zoula, Sonia C.; Keyzer, Frederik De; Mohaupt, Markus; Studer, Urs E.; Vermathen, Peter

doi:10.1148/radiol.2473070877

Cited by 51 publications

(40 citation statements)

References 26 publications

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“…This correlation was demonstrated by earlier studies that have assessed OS in CRF using BOLDfMRI but in renal tissue and not in the brain [35,36] .…”

Section: Discussionsupporting

confidence: 52%

Blood Oxygenation Level-Dependent Functional MRI of Early Evidences of Brain Plasticity after Hemodialysis Session by Helixone Membrane of Patients with Indices of Adrenal Deficiency

Boujraf¹,

Belaïch²,

Housni³

et al. 2017

Ann Neurosci

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Background: Various alterations of hypothalamic-pituitary-adrenal axis function have been described in patients with chronic renal failure. Nevertheless, controversial evidences were stated about the association between adrenal function deficiency (AD) and hemodialysis (HD). Purpose: The goal of this paper was to estimate indirect indices of the adrenal gland dysfunction which is potentially influenced by oxidative stress (OS) that still generates brain plasticity and reorganization of the functional control.Methods: Two male patients undergoing HD by the synthetic Helixone membrane for more than 6 months at the HD Center of the University Hospital of Fez, Fez, Morocco, were recruited. They underwent identical assessment immediately before and after the full HD session; this consisted of a blood ionogram revealing rates of sodium and calcium, and brain blood oxygenation level-dependent functional MRI (BOLD-fMRI) using a motor paradigm in block design. Results: The blood ionogram revealed hypercalcemia and hyponatremia in both patients. Both biological assessment and BOLD-fMRI study results revealed a high level of OS that induced activation of a significantly large brain volume area suggesting the occurrence of possible brain plasticity and functional control reorganization induced by free radicals and enhanced by AD. Conclusion: The occurrence of brain plasticity and functional control reorganization was demonstrated in both patients studied who were undergoing HD by BOLD-fMRI with a notable sensitivity; this plasticity is induced by elevated OS occasioned by HD technique itself and probably amplified by AD. Similar results were found in a previous study performed on the same patients undergoing HD by a polysulfone membrane.

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“…This correlation was demonstrated by earlier studies that have assessed OS in CRF using BOLDfMRI but in renal tissue and not in the brain [35,36] .…”

Section: Discussionsupporting

confidence: 52%

Blood Oxygenation Level-Dependent Functional MRI of Early Evidences of Brain Plasticity after Hemodialysis Session by Helixone Membrane of Patients with Indices of Adrenal Deficiency

Boujraf¹,

Belaïch²,

Housni³

et al. 2017

Ann Neurosci

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“…In our study, in three recipients the decrease in renal function was caused by ureteric obstruction, which may induce significant changes in the oxygenation of native kidneys [21]. Experimental animal studies have shown an initial increase of renal blood perfusion in the first hours of ureteric obstruction, which is followed by subsequent hypoperfusion of the renal cortex [22].…”

Section: Discussionmentioning

confidence: 58%

Quantification of renal allograft perfusion using arterial spin labeling MRI: initial results

et al. 2009

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“…77 In human subjects with partial unilateral ureteral obstruction due to renal stones and treated with nonsteroidal anti-inflammatory drugs, medullary and, to a lesser extent, cortical oxygenation were enhanced. 78 The contralateral nonobstructed kidney showed reduced medullary oxygenation. However, interpretation of these data is confounded by universal exposure of subjects to prostaglandin inhibition.…”

Section: Obstructive Uropathymentioning

confidence: 99%

Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Neugarten¹,

Golestaneh²

2014

IJNRD

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Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) has recently emerged as an important noninvasive technique to assess intrarenal oxygenation under physiologic and pathophysiologic conditions. Although this tool represents a major addition to our armamentarium of methodologies to investigate the role of hypoxia in the pathogenesis of acute kidney injury and progressive chronic kidney disease, numerous technical limitations confound interpretation of data derived from this approach. BOLD MRI has been utilized to assess intrarenal oxygenation in numerous experimental models of kidney disease and in human subjects with diabetic and nondiabetic chronic kidney disease, acute kidney injury, renal allograft rejection, contrast-associated nephropathy, and obstructive uropathy. However, confidence in conclusions based on data derived from BOLD MRI measurements will require continuing advances and technical refinements in the use of this technique.

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Renal Oxygenation Changes during Acute Unilateral Ureteral Obstruction: Assessment with Blood Oxygen Level–Dependent MR Imaging—Initial Experience

Abstract: Increased oxygen content in the renal cortex and medulla occurs with acute unilateral ureteral obstruction, suggesting reduced function of the affected kidney.

Cited by 51 publications

References 26 publications

Blood Oxygenation Level-Dependent Functional MRI of Early Evidences of Brain Plasticity after Hemodialysis Session by Helixone Membrane of Patients with Indices of Adrenal Deficiency

Blood Oxygenation Level-Dependent Functional MRI of Early Evidences of Brain Plasticity after Hemodialysis Session by Helixone Membrane of Patients with Indices of Adrenal Deficiency

Quantification of renal allograft perfusion using arterial spin labeling MRI: initial results

Blood oxygenation level-dependent MRI for assessment of renal oxygenation

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