Renal Perfusional Cortex Volume for Arterial Input Function Measured by Semiautomatic Segmentation Technique Using MDCT Angiographic Data With 0.5-mm Collimation

Torimoto, Izumi; Takebayashi, Shigeo; Sekikawa, Zenjiro; Teranishi, Jun‐ichi; Uchida, Keiji; Inoue, Tomio

doi:10.2214/ajr.14.12778

Cited by 9 publications

(10 citation statements)

References 18 publications

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“…This value is consistent with, although somewhat lower than previous reports of cortical volume of approximately 90 to 120 cm 3 per kidney 3,4,7 . Previous studies have shown that a range of factors influence cortical volume including age, gender, renal function, diabetes, hypertension, body size, and renal morphological parameters 3,4,6,7,13,14 . In this study, we tried to produce a model by applying these factors as candidate explanatory variables for cortical volume.…”

Section: Discussionmentioning

confidence: 99%

Estimation of nephron number in living humans by combining unenhanced computed tomography with biopsy-based stereology

Sasaki

Tsuboi

Okabayashi

et al. 2019

Sci Rep

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Methods for estimating nephron number in a clinical setting may be useful for predicting renal outcomes. This study aimed to establish such a method using unenhanced computed tomography (CT) and biopsy-based stereology. Patients or living kidney donors simultaneously subjected to enhanced and unenhanced CT examinations were randomly assigned to development and validation groups. The enhanced CT-measured arterial phase and the venous phase images of kidneys were regarded as the true values for cortical volume and parenchymal volume, respectively. Linear multiple regression analysis was used to create models for estimating cortical volume using explanatory variables including unenhanced CT-measured parenchymal volume. Nephron number was determined as the product of cortical volume and the glomerular density in biopsies of donors. Five equations for estimating cortical volume were created and verified. In donors, estimated nephron number by unenhanced CT was consistent with that by enhanced CT, with minimal errors in all models (636–655 ± 210–219 vs. 648 ± 224 × 103/kidney). Clinical characteristics combined with parenchymal volume did not improve the equation over parenchymal volume alone. These results support the feasibility of estimating nephron number by a combination of unenhanced CT and biopsy-based stereology, with a possible application for renal disease patients who are often not suitable for contrast media.

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Section: Discussionmentioning

confidence: 99%

Estimation of nephron number in living humans by combining unenhanced computed tomography with biopsy-based stereology

Sasaki

Tsuboi

Okabayashi

et al. 2019

Sci Rep

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“…Because of advances in multidetector computed tomography (MDCT) technology, more than 64 rows of scanning enable faster acquisition of volumetric image data with superior z-axis resolution with a thin collimation for CT angiography. Compared to complicated and time-consuming manual volumetric assessment as the plotting contour method, automatic or semiautomatic segmentation using various postprocessing techniques can greatly reduce the required time and increase the potential accuracy of measurement [7]. Recently, we found that curved planar reformations (CPR), found by using MDCT angiographic data, which allow the demonstration of plaques with attenuation-dependent color codes, can be applied to the measurement of plaque volume [8].…”

Section: Introductionmentioning

confidence: 99%

Aortic and Internal Carotid Atherosclerosis in Patients with Carotid Stenosis: Semiautomatic Volumetric Analysis of Low-Attenuation Plaque on Curved Planar Reformations Using MDCT Angiographic Data

Manaka

Torimoto

Sekikawa

et al. 2019

BioMed Research International

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This retrospective study included 65 patients who underwent multidetector computed tomography (MDCT) carotid angiography; 28 patients were <70 years old (group 1), and 37 were ≥70 years old (group 2). Each low-attenuation (<30 Hounsfield units [HU]) plaque volume (LPV) and total uncalcified plaque volume ([TUPV] ≤150 HU) were semiautomatically measured on each aortic arch and internal carotid artery (ICA) curved planar reformations (CPR), using MDCT angiographic data. Correlation coefficients were employed to assess the impact of each plaque volume on various factors including ICA stenosis. The correlations (r > 0.5) were observed between aortic LPV and each ICA stenosis ratio and >30% stenosis in group 1, between aortic TUPV and male gender in group 1, and between ICA-TUPV and each aortic TUPV or the largest plaque thickness in group 2. Marginal correlations were observed between hyperlipidemia and aortic LPV and ICA-TUPV in group 1. There was no association between cerebral infarction and the aortic and ICA plaques. Both the aortic arch and ICA plaque volumes can be measured clinically. The increasing aortic LPV may be a significant factor associated with the development of ICA stenosis in patients younger than 70 years old.

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“…Chatzikonstantinou et al [ 8 ] reported that 64-row MDCT angiography could detect more plaques in a grading system throughout the aortic arch compared to TEE. Volumetric data acquired with a thinner collimation is expected to provide more accurate volume measurement [ 9 ]. Curved planar reformations (CPR) which allow a single two-dimensional image display of structures that run through multiple oblique planes have been reported to be useful in evaluating the regional calcified plaque condition of the coronary artery [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Semiautomatic Volumetry of Low Attenuation of Thoracic Aortic Plaques on Curved Planar Reformations Using MDCT Angiographic Data with 0.5 mm Collimation

Mizutani

Torimoto

Sekikawa

et al. 2018

BioMed Research International

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To evaluate the relationship of aortic low attenuation plaque volume (LAPV) on multidetector computed tomography (MDCT) with the abdominal aortic aneurysm (AAA), the coronary arterial disease (CAD, ≥50% stenosis), severe (≥90% stenosis) CAD, hypertension, and long-term (≥10 years) hypertension. Curved planar reformations (CPR) of three segments (the ascending, the arch, and the upper descending aorta) of the thoracic aorta were generated with attenuation-dependent color codes to measure LAPV with 0~29 HU and total noncalcified plaque volume (TNPV) with 0~150 HU in 95 patients. Correlation coefficients were employed to assess the impact of each LAPV and TNPV on AAA, CAD, severe CAD, hypertension, and long-term hypertension. Each Mean LAPV/cm and TNPV/cm was statistically greater in the aortic arch than the ascending (p < 0.001 on each) or the proximal descending segment (p < 0.001 on each). LAPV in the aortic arch has moderate correlations with AAA, severe CAD, and long-term hypertension (r = 0.643, 0.639, 0.662, resp.). Plaque volumes in each aortic segment can be measured clinically and the increasing LAPV in the arch may be a significant factor associated with the development of severe atherosclerosis underlying AAA, severe CAD, and long-term hypertension.

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Renal Perfusional Cortex Volume for Arterial Input Function Measured by Semiautomatic Segmentation Technique Using MDCT Angiographic Data With 0.5-mm Collimation

Abstract: Weight-adjusted perfusional cortex volume for arterial input function can be measured clinically and may replace renal DTPA scanning using the modified Gates method.

Cited by 9 publications

References 18 publications

Estimation of nephron number in living humans by combining unenhanced computed tomography with biopsy-based stereology

Estimation of nephron number in living humans by combining unenhanced computed tomography with biopsy-based stereology

Aortic and Internal Carotid Atherosclerosis in Patients with Carotid Stenosis: Semiautomatic Volumetric Analysis of Low-Attenuation Plaque on Curved Planar Reformations Using MDCT Angiographic Data

Semiautomatic Volumetry of Low Attenuation of Thoracic Aortic Plaques on Curved Planar Reformations Using MDCT Angiographic Data with 0.5 mm Collimation

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