Renal Primitive Neuroectodermal Tumors

Bartholow, Tanner L.; Parwani, Anil V.

doi:10.5858/arpa.2011-0104-rs

Cited by 16 publications

(16 citation statements)

References 26 publications

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“…Although PNETs can occur in a number of organs, such as in the kidneys,1 brain,2 and lungs,3 they also occur very rarely in the cervix. As far as we are aware, only nine cases have been reported.…”

Section: Introductionmentioning

confidence: 99%

Primary primitive neuroectodermal tumor of the cervix

Li¹,

Ouyang²,

Xue³

et al. 2013

OTT

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Primary primitive neuroectodermal tumors (PNETs) are rare and high-grade malignant tumors that mostly occur in children and young adults. The most common sites are the trunk, limbs, and retroperitoneum. Herein, we present a case of a PNET involving the cervix uteri in a 27-year-old woman. The lesion showed characteristic histologic features of a PNET and was positive for the immunohistochemical markers cluster of differentiation (CD) 99, vimentin, neuron-specific enolase, neural cell adhesion molecule 1 (CD56), and CD117 (c-kit), further defining the tumor while helping to confirm PNET. The clinical Stage IIIB tumor was treated with chemotherapy and radiotherapy.

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Section: Introductionmentioning

confidence: 99%

Primary primitive neuroectodermal tumor of the cervix

Li¹,

Ouyang²,

Xue³

et al. 2013

OTT

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“…ERG will aid in making the correct diagnosis [1,37]. Epithelioid angiosarcoma may occur as a primary tumor in the kidney and it may demonstrate rhabdoid morphology and CD10 positivity.…”

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confidence: 99%

Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects

Karashima¹,

Inoue²,

Kasajima³

et al. 2015

pjp

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“…Immunohistochemistry can be used to help in confi rming PNET diagnosis. CD99 positivity is reported in the vast majority of lesions and further negative staining with WT-1 and CD45 can help to further separate PNET from Wilms' tumor and non-Hodgkin lymphoma respectively [ 113 ].…”

Section: Primitive Neuroectodermal Tumorsmentioning

confidence: 99%

“…Primitive neuroectodermal tumor (PNET) of the kidney belongs to a family of tumors that include Ewing sarcoma and Askin tumor, together comprising about 1 % of all sarcomas [ 113 ]. Specifi cally, PNET is a poorly differentiated neoplasm arising from the cells of the neuroectoderm that can occur anywhere in the soft tissues and rarely in the kidneys [ 114 ].…”

Section: Primitive Neuroectodermal Tumorsmentioning

confidence: 99%

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Malignant Renal Tumors

Shehata

Naguib

Lin

et al. 2014

Pediatric Malignancies: Pathology and Imaging

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Renal tumors account for approximately 6-7 % of all pediatric cancers, with Wilms' tumor being the most common malignancy [ 1 , 2 ]. Current classifi cation and staging criteria for renal tumors, aided by advances in molecular and cytogenetic abnormalities, have allowed accurate diagnostic, staging, and therapeutic protocols [ 2 ], elucidated new categories of renal neoplasms, and created more inclusive classifi cation (Table 10.1 ) [ 2 , 3 ]. Overview of Imaging FeaturesThe imaging evaluation of a suspected pediatric renal mass should always begin with ultrasound. Sonography is readily available, can be performed without sedation and intravenous contrast, and does not expose the child to ionizing radiation. If a renal mass is identifi ed on ultrasound, further evaluation of the renal vessels and inferior vena cava (IVC) with both gray scale and color Doppler images are required to detect vascular extension, present in up to 10 % of cases [ 4 ]. Further evaluation with contrast enhanced computed tomography (CT) or magnetic resonance imaging (MRI) is also required for local staging of the mass prior to any intervention, as per the guidelines of the Children's Oncology Group (COG). Either modality can be used, depending on institutional availability and expertise [ 5 ].In keeping with the As Low As Reasonably Achievable (ALARA) principle regarding ionizing radiation exposure, pre-contrast and multiphase contrast enhanced CT images are not required for diagnosis or staging of pediatric renal tumors [ 6 ]. A single-phase study in the portal venous phase (approximately 50 s after contrast injection) suffi ciently stages a renal tumor and delineates relevant anatomy. Multiplanar CT reconstructions or multiplanar scanning with MRI can confi rm the renal origin of the mass and assess its relationship to vital structures such as the renal vessels. If a partial nephrectomy is being considered, multiphase images are helpful to determine the relationship of the mass to the renal vessels and collecting system. A CT of the chest is required in all malignant renal tumors to evaluate for potential lung metastasis. Wilm's Tumor Defi nitionWilms' tumor ( syn: nephroblastoma), a malignant neoplasm originating from nephrogenic blastemal cells, is the second most common malignant, solid extracranial tumor in children [ 1 , 7 , 8 ]. It is a traditional blastematous tumor, exhibiting various stages of embryonic development and multiple lines of differentiation. Clinical Features and EpidemiologyIn children ranging from 0 to 15 years of age, Wilms' tumor occurs in seven to ten cases per million annually (1 in 10,000 children) and accounts for approximately 95 % of renal tumors, and comprises 6-7 % of all pediatric tumors [ 7 , 9 , 10 ]. It is the fi fth most common pediatric tumor and the second most common intraabdominal tumor in children [ 11 ].

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Renal Primitive Neuroectodermal Tumors

Cited by 16 publications

References 26 publications

Primary primitive neuroectodermal tumor of the cervix

Primary primitive neuroectodermal tumor of the cervix

Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects

Malignant Renal Tumors

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