Renal tissue oxygenation after caffeine administration in preterm neonates

Harer, Matthew W.; Rothwell, Amy C.; Richard, Luke; Adegboro, Claudette O.; McAdams, Ryan M.

doi:10.1038/s41390-021-01579-3

Cited by 9 publications

(7 citation statements)

References 20 publications

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“…The issue offers additional support in the debate regarding Methylxanthines administration side‐effects, with particular regard to aminophylline 16 ; (ii) fit in part previous observations confirming an increased K blood flow and tissue activation. Discrepancies regard the different devices used and monitoring time‐points (3 h vs. 4–6 h) 19,36 . All in all, beneficial effects of caffeine administration were confirmed since none of the infants admitted into the study showed oliguria and/or blood ion level alterations, 36 and (iii) in the splanchnic district partly agreed with previous observations.…”

Section: Discussionsupporting

confidence: 79%

“…Discrepancies regard the different devices used and monitoring time-points (3 h vs. 4-6 h). 19,36 All in all, beneficial effects of caffeine administration were confirmed since none of the infants admitted into the study showed oliguria and/or blood ion level alterations, 36 and (iii) in the splanchnic district partly agreed with previous observations. The increased tissue activation may be related to caffeine administration as well as to metabolic changes occurring in the first post-natal days such as respiratory and feeding management.…”

Section: F I G U R Esupporting

confidence: 84%

“…[14][15][16][17][18] Notably, gastrointestinal hemodynamic changes, as expression of local hypoperfusion, were observed, as well as kidney district perfusion was improved. [15][16][17][18][19] At this stage, although caffeine constituted a standard drug for apnoea treatment in preterm infants, data regarding its effects on cerebral, kidney and splanchnic circulations is still lacking.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, in preterm infants treated by caffeine or methylxanthines, near infrared spectroscopy (NIRS) patterns were characterised by temporarily cerebral oxygenation reduction and increase in tissue oxygen extraction 14–18 . Notably, gastrointestinal hemodynamic changes, as expression of local hypoperfusion, were observed, as well as kidney district perfusion was improved 15–19 …”

Section: Introductionmentioning

confidence: 99%

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Cerebral and systemic near infrared spectroscopy patterns in preterm infants treated by caffeine

Strozzi,

Di Battista,

Graziosi

et al. 2023

Acta Paediatrica

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AimTo investigate the effects of caffeine loading/maintenance administration on near‐infrared spectroscopy cerebral, kidney and splanchnic patterns in preterm infants.MethodsWe conducted a multicentre case–control prospective study in 40 preterm infants (gestational age 29 ± 2 weeks) where each case acted as its own control. A caffeine loading dose of 20 mg/kg and a maintenance dose of 5 mg/kg after 24 h were administered intravenously. Near infrared spectroscopy monitoring parameters were monitored 30 min before, 30 min during and 180 min after caffeine therapy administration.ResultsA significant increase (p < 0.05) in splanchnic regional oxygenation and tissue function and a decrease (p < 0.05) in cerebral tissue function after loading dose was shown. A preferential hemodynamic redistribution from cerebral to splanchnic bloodstream was also observed. After caffeine maintenance dose regional oxygenation did not change in the monitored districts, while tissue function increased in kidney and splanchnic bloodstream.ConclusionDifferent caffeine administration modalities affect cerebral/systemic oxygenation status, tissue function and hemodynamic pattern in preterm infants. Future studies correlating near infrared spectroscopy parameters and caffeine therapy are needed to determine the short/long‐term effect of caffeine in preterm infants.

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Section: Discussionsupporting

confidence: 79%

Section: F I G U R Esupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cerebral and systemic near infrared spectroscopy patterns in preterm infants treated by caffeine

Strozzi,

Di Battista,

Graziosi

et al. 2023

Acta Paediatrica

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“…In neonates with hypoxic ischemic encephalopathy, a single dose of theophylline in the first six hours of birth reduces the rate of AKI [ 20 ]. In preterm neonates, caffeine has been shown to improve renal oxygenation, and those on caffeine have reduced rates of AKI [ 21 , 22 ]. Finally, and most importantly, children with low rSO 2 in the 1 h post-cardiopulmonary bypass may require additional attention in avoiding additional hits to the kidneys, including the administration of nephrotoxic drugs, and ensuring an appropriate level of hydration, optimal end organ perfusion, and optimal oxygen delivery.…”

Section: Discussionmentioning

confidence: 99%

Decreased Intraoperative Renal Tissue Oxygenation after Cardiopulmonary Bypass Predicts Cardiac Surgery-Associated Acute Kidney Injury in Neonates

Condit,

Gorski,

Lasarev

et al. 2024

Children

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(1) Background: Near-infrared spectroscopy (NIRS) is a noninvasive tool frequently used during cardiac surgery and postoperatively in the cardiac intensive care unit to monitor regional tissue oxygen saturation. A relationship between trends of intraoperative renal oxygenation and the risk of developing cardiac surgery-associated acute kidney injury (AKI) post-operatively has not yet been established in the neonatal population. The objective of this study is to evaluate the relationship of cerebral and renal oxygenation during cardiopulmonary bypass with cardiac surgery-associated AKI in the first 72 h post-operation in neonates < 30 days of age. (2) Methods: A prospective cohort study at a tertiary care children’s hospital was performed. Renal and cerebral oxygenation measured were collected intraoperatively from neonates < 30 days of age who underwent cardiopulmonary bypass for the correction of congenital heart disease. AKI was defined accordance with the Kidney Disease: Improving Global Outcomes criteria modified for neonates. Variables were compared between groups. (3) Results: 32 neonates with 35 cardiopulmonary bypass cases were included. AKI was diagnosed in 60% of cases. Intra-operative renal oxygenation, both on- and off-bypass, did not differ among the three AKI groups (p > 0.19). Renal oxygenation after coming off, but not during, cardiopulmonary bypass steadily decreased with increasing levels of AKI (Jonckheere’s test, one-sided p = 0.024). (4) Conclusions: Renal oxygenation decreased in proportion to AKI severity after coming off, but not during, cardiopulmonary bypass.

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Acute Effects of Aminophylline Effects on Hemodynamic Parameters and Fluid Balance in Pediatric Cardiac Intensive Care Patients: Machine Learning Insights Using High Fidelity Data

Loomba,

Patel,

Miceli

et al. 2024

Pediatr Cardiol

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Renal tissue oxygenation after caffeine administration in preterm neonates

Cited by 9 publications

References 20 publications

Cerebral and systemic near infrared spectroscopy patterns in preterm infants treated by caffeine

Cerebral and systemic near infrared spectroscopy patterns in preterm infants treated by caffeine

Decreased Intraoperative Renal Tissue Oxygenation after Cardiopulmonary Bypass Predicts Cardiac Surgery-Associated Acute Kidney Injury in Neonates

Acute Effects of Aminophylline Effects on Hemodynamic Parameters and Fluid Balance in Pediatric Cardiac Intensive Care Patients: Machine Learning Insights Using High Fidelity Data

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