Renal Transplantation: Experience at a Single Centre

Murty, M. S. N.; Saxena, Vipin; Sharma, Upender; Tandon, Sanjeev; Sharma, Preeti

doi:10.1016/s0377-1237(09)80047-6

Cited by 3 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This cohort also excludes data from patients who received ATG for BPAR within 6 months post‐KT but developed their first episode of bacteriuria greater than 6 months post‐KT. Studies in India and Tunisia concluded that patients receiving ATG, among other forms of immunosuppression, for acute rejection are at higher risk of UTIs despite prophylaxis with sulfadoxin‐pyramethamine 27,28 . Future studies should focus on whether patients receiving ATG alone for acute rejection are a subpopulation at high risk for subsequent urinary tract infections meriting targeted antimicrobial prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial resistance and recurrent bacterial urinary tract infections in hospitalized patients following kidney transplantation: A single‐center experience

Greissman

Mattiazzi

Mendoza

et al. 2020

Transplant Infectious Dis

View full text Add to dashboard Cite

Purpose The burden of urinary tract infections (UTIs) and risk factors for developing infections with multidrug resistant organisms (MDROs) post‐kidney transplantation (KT) are poorly understood. Methods Single‐center retrospective cohort study (January 2015‐December 2017) evaluating first and recurrent episodes of bacteriuria and subsequent analysis of episodes caused by MDROs up to 6 months post‐KT. Donor and recipient variables were reviewed. Results A total of 743 adults underwent single KT during the study period, and 106 patients were hospitalized with bacteriuria. 45% were asymptomatic in their first episode. 73.6% had a single episode, and 26.4% had 2 or more episodes. A total of 28 patients had recurrent episodes; 64.3% had an MDRO on the first episode and 78.6% on the second episode. Escherichia coli was the most common organism isolated, 88.5% were resistant to trimethoprim‐sulfamethoxazole (TMP‐SMX), 9.3% were extended‐spectrum beta‐lactamase (ESBL) producers, and 38.1% were MDROs. Body mass index ≥30 was significantly associated with the presence of MDROs in both univariate and multivariate analyses (RR 1.37, 95% CI 1.01‐1.88; OR 3.26, CI 1.29‐8.25). A total of 12 donors had bacteremia or bacteriuria and 6 (50%) with E coli. A total of 10 KT recipients received antibiotic prophylaxis to prevent donor‐derived infections. Conclusions Our results suggest that a significant proportion of patients develop recurrent bacteriuria post‐transplantation; of those, more than half caused by MDROs. There is a possible association between obesity and MDROs in KT recipients that merits further investigation. With the global crisis in antimicrobial resistance, innovative strategies are needed to prevent and treat UTIs in KT patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Antimicrobial resistance and recurrent bacterial urinary tract infections in hospitalized patients following kidney transplantation: A single‐center experience

Greissman

Mattiazzi

Mendoza

et al. 2020

Transplant Infectious Dis

View full text Add to dashboard Cite

show abstract

Prevention and management of tuberculosis in solid organ transplantation: A consensus statement of the transplantation society of Taiwan

Chiang

Chen

Feng

et al. 2023

Journal of the Formosan Medical Association

View full text Add to dashboard Cite

Kidney transplant and its outcomes

Banode

Kimmatkar

Bawankule

et al. 2021

Journal of Current Research in Scientific Medicine

View full text Add to dashboard Cite

Background: Kidney transplantation has become the treatment of choice for most patients with end-stage kidney disease (ESKD). However, there is a remarkable disparity in the access and outcome of kidney transplant across the world. We present the clinical and survival data from the nephrology and kidney transplantation center for a period of 5 years in a cost-limited setting from Central India. Materials and Methods: This is a retrospective study of 66 kidney transplants performed in a single transplant center over a period of 5 years from 2016 to 2020. All data of recipients and donors were obtained from hospital records. Kaplan–Meier method was used for survival analysis. Results: Of 66 included patients, 86% were living donor and 14% were cadaveric kidney transplant. The mean age of the recipient was 30.64 ± 10.66 years. Fifty-five (83%) were male recipients and 11 (17%) were female recipients. The most common cause of ESKD in recipients was chronic glomerulonephritis (55%). The mean hemodialysis vintage was 11.04 ± 10.12 months. Seventy-four percent of donors were female and 24% of donors were male. Induction therapy with rabbit antithymocyte globulin was used in 20 (30%) and basiliximab in 21 (32%) recipients. Thirty (45%) recipients underwent graft kidney biopsy in view graft dysfunction. Acute cellular rejection was the most common cause of graft dysfunction seen in 8 (28%) of graft kidney biopsy. Graft survival and patient survival at 1, 3, and 5 years after transplant were 89%, 81%, and 77% and 90%, 84%, and 81%, respectively. Conclusions: Our observation showed that graft survival and patient survival after transplant were lower compared to other studies due to higher rejection rate and mortality due to infections. Hence, attention to immunological risk factors with proper immunologic testing pretransplant and early detection and adequate treatment of rejection episode even in cost-limited settings are suggested. Also after kidney transplant, prevention and prompt treatment of infection would offer the greatest potential to improve the chance of living longer with functioning graft.

show abstract

Renal Transplantation: Experience at a Single Centre

Cited by 3 publications

References 15 publications

Antimicrobial resistance and recurrent bacterial urinary tract infections in hospitalized patients following kidney transplantation: A single‐center experience

Antimicrobial resistance and recurrent bacterial urinary tract infections in hospitalized patients following kidney transplantation: A single‐center experience

Prevention and management of tuberculosis in solid organ transplantation: A consensus statement of the transplantation society of Taiwan

Kidney transplant and its outcomes

Contact Info

Product

Resources

About