Renal tubular function in children with β‐thalassemia minor

Kalman, Süleyman; Atay, Avni; Sakallıoğlu, Onur; Özgürtaş, Taner; Gök, Faysal; Kurt, İsmail; Kürekçi, Ahmet Emin; Ozcan, Okan; Gökçay, Erdal

doi:10.1111/j.1440-1797.2005.00484.x

Cited by 10 publications

(19 citation statements)

References 12 publications

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“…2,3,12 In one study where TPR values were compared between patients with TMin and healthy subjects, no difference was found. 4 However, there have also been studies on the contrary to our results. Aldudak et al 6 and Hamed and Elmelegy 16 reported that TPR levels were significantly lower in patients with TM than in healthy controls.…”

Section: Discussioncontrasting

confidence: 96%

“…There have been studies showing FENa levels increased as an indicator of poor renal function in beta thalassemia patients, 5,10-12 whereas there has also been studies suggesting that this parameter showed no difference. 2,4,6,13 Data regarding the significance of alpha-1M excretion in thalassemia are limited. Our study showed that alpha-1M excretion increased in patients with TM and TI.…”

Section: Discussionmentioning

confidence: 99%

“…3,10,12,16 One study showed that urinary excretion of beta-2 m was not different between children with TMin and healthy controls. 4 Thus, we suggest that beta-2 m may be taken as a reliable marker of tubular dysfunction in patients with thalassemia major (TM).…”

Section: Discussionmentioning

confidence: 99%

“…2,3,5,13,17 Two other studies reported that urinary calcium excretion was high in patients with TMin and it was emphasized that these patients had an increased osteoporosis. 4,11 Urinary excretion of phosphorus may increase in patients with beta thalassemia, due to rapid erythrocyte turnover, hemolysis and proximal tubular damage. 6 Phosphaturia can be shown by decreased TPR.…”

Section: Discussionmentioning

confidence: 99%

“…The severity correlated with the degree of anemia is least severe in patients on hyper transfusion and iron chelation therapy, suggesting that the damage might be caused by the anemia and increased oxidation induced by excess iron deposits. [1][2][3][4][5][6][7][8][9] Although it was reported that urinary excretion of proximal renal tubular damage parameters increased in patients with TM and TI, renal functional parameters were not separately studied as glomerular and tubular markers in all types of the disease. The aims of the present study were to assess the glomerular and tubular renal functions in three different types of beta thalassemia, and to identify the similarities and differences between groups and to compare with healthy controls.…”

Section: Introductionmentioning

confidence: 99%

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Glomerular and tubular functions in children with different forms of beta thalassemia

Uzun

Balcı²,

Yüksel

et al. 2015

Renal Failure

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Background: Although there are many available data about renal involvement in patients with beta thalassemia major (TM), the changes in renal functions of other types, such as thalassemia intermedia (TI) and thalassemia minor (TMin), were reported less. Therefore, we aimed to evaluate renal tubular and glomerular functions in patients with three types of beta thalassemia. Methods: This prospective case-control study was conducted on 118 betathalassemia patients (49 in TM, 18 in TI and 51 TMin) and 51 healthy controls. Glomerular functions [estimated glomerular filtration rate (GFR), serum cystatin C and urinary protein creatinine ratio] and tubular functions [fractioned sodium excretion (FENa), tubular reabsorption of phosphorus, urinary excretion of uric acid, levels of retinol-binding protein, alpha-1 macroglobulin (alpha-1M), and beta-2 microglobulin, calcium creatinine ratio] were assessed in all patients and controls. Results: The mean ages of the groups and controls at presentation were similar. Although GFR was similar in all patients and control groups, serum levels of cystatin C in patients with TM and TI were significantly higher compared to TMin and controls. Alpha-1M, FENa, urinary excretion of uric acid, and urine protein/creatinine ratio in TM and TI groups were significantly higher than the others. Mean cystatin C level was also higher in patients with TMin compared the controls. However, there were no significant differences according to all tubular and other glomerular functions between TMin and control groups. Conclusions: Although all types of beta thalassemia patients should be closely monitored to prevent further decrease in renal functions, the patients with TI should be considered to have a higher risk of glomerular and tubular deterioration as well as TM.

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Section: Discussioncontrasting

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Glomerular and tubular functions in children with different forms of beta thalassemia

Uzun

Balcı²,

Yüksel

et al. 2015

Renal Failure

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Reversible Fanconi syndrome in a pediatric patient on deferasirox

Rheault

Bechtel

Neglia

et al. 2010

Pediatric Blood & Cancer

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Deferasirox (Exjade®, Novartis) is a widely used oral iron chelator for the treatment of patients with iron overload due to chronic transfusion therapy for diseases such as β-thalassemia and sickle cell disease. Renal side effects of deferasirox are common and include non-progressive increases in serum creatinine, however, the effect of deferasirox on proximal tubule function is unclear. We report one pediatric patient with reversible Fanconi syndrome associated with long-term deferasirox therapy and one patient with mild proximal tubular dysfunction. Kidney and proximal tubular function should be periodically monitored in patients receiving deferasirox throughout their course of therapy.

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The Case | Microhematuria in a patient with beta-thalassemia major: a casual or a causal association?

Piccoli

Roggero

Pascale³

et al. 2014

Kidney International

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A 42-year-old woman, with transfusion-dependent thalassemia major (CD39/CD39) since 1 year of age, seeks nephrological attention for microhematuria. Her medical history includes most of the long-term problems known to occur in long-standing beta-thalassemia: she is HCV positive (genotype 1b), with HCV-related chronic liver disease with type III cryoglobulinemia and arthritis (treated with steroids and cyclosporine A, and later switched to methotrexate); she also developed steroid-induced diabetes and hypogonadism because of iron overload, and thalassemia-related osteoporosis (moderate-severe reduction of the bone density) with a possible steroid-related component; she underwent splenectomy at the age of 17 years. She complained of two episodes of renal colic in the past 5 years without stone passing.

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Renal tubular function in children with β‐thalassemia minor

Abstract: On the contrary of children with beta-thalassemia major, renal tubular dysfunction has not been determined in children with beta-thalassemia minor in the present study.

Cited by 10 publications

References 12 publications

Glomerular and tubular functions in children with different forms of beta thalassemia

Glomerular and tubular functions in children with different forms of beta thalassemia

Reversible Fanconi syndrome in a pediatric patient on deferasirox

The Case | Microhematuria in a patient with beta-thalassemia major: a casual or a causal association?

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