Renin Angiotensin System Components and Cancer: Reports of Association

Abstract

Objectives. The study assessed the existence and significance of associations between the expression of fifteen renin-angiotensin system component genes and lung adenocarcinoma. Materials and Methods. NCBI's built-in statistical tool, GEO2R, was used to calculate Student's í µí±¡-tests for the associations found in a DNA expression study of adenocarcinoma and matched healthy lung tissue samples. The raw data was processed with GeneSpring6 and then used to generate figures with and without Sidak's multiple comparison correction. Results. Ten genes were found to be significantly associated with adenocarcinoma. Seven of these associations remained statistically significant after correction for multiple comparisons. Notably, AGTR2, which encodes the AT 2 angiotensin II receptor subtype, was significantly underexpressed in adenocarcinoma tissue (í µí± < 0.01). AGTR1, ACE, ENPEP, MME, and PRCP, which encode the AT 1 angiotensin II receptor, angiotensin-converting enzyme, aminopeptidase N, neprilysin, and prolylcarboxypeptidase, respectively, were also underexpressed. AGT, which encodes angiotensinogen, the angiotensin peptide precursor, was overexpressed in adenocarcinoma tissue. Conclusion. The results suggest an association between the expression of the genes for renin-angiotensin system-related proteins and adenocarcinoma. While further research is necessary to conclusively demonstrate a link between the renin-angiotensin system and lung cancers, the results suggest that the renin-angiotensin system plays a role in the pathology of adenocarcinoma.

Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals

“…The literature confirms changes in selected components of the RAS in different types of tumors, including OC. The mechanisms of tumorigenesis and cancer progression associated with these changes still remain unclear [ 89 , 90 , 91 ]. It has been described that the ACE2/Ang1-7/MAS1 cascade opposes the effects of the ACE1/Ang II/AT1 receptor axis, inhibiting cancer cell proliferation, reducing the migratory potential and invasiveness, limiting the formation of new blood vessels.…”

Angiotensin II and Angiotensin Receptors 1 and 2—Multifunctional System in Cells Biology, What Do We Know?

“…AT1R and AT2R are supposed to play different roles during cancerogenesis. Ang II acting via AT1R is correlated with proliferative, anti-apoptotic, pro-angiogenic, pro-inflammatory, and metastatic actions and blockage of cell cycle in G1 phase, while AT2R is related to the attenuation of tumor growth, induction of apoptosis, and differentiation [ 24 , 25 ]. Moreover, ATR2 presents overall protective and regenerating actions like anti-inflammatory and anti-fibrotic properties [ 26 ].…”

Renin-angiotensin system: role in the development and progression of prostate cancer

“…В последнее время появились доказательства того, что компоненты РАС участвуют в развитии различных видов рака: гепатоцеллюлярной карциномы, рака молочной железы, рака эндометрия, миеломы, рака легкого, РПЖ, меланомы, рака поджелудочной железы, миеломы, рака почки, лейомиомы, рака полости рта [31]. АПФ участвует в процессах клеточной пролиферации, миграции опухолевых клеток, ангиогенезе, метастазировании.…”

“…АТ1-R и Анг II оказывают провоспалительное, проангиогенное, пролиферативное, антиапоптозное, метастатическое и митогенное действие. АТ2-R и Анг1-7 являются отрицательными регуляторами роста, индуцируют апоптоз, ослабление роста опухоли, коррелируют с безрецидивной выживаемостью [31].…”