Renin angiotensin system polymorphisms in patients with metabolic syndrome (MetS)

Procopciuc, Lucia Maria; Sitar-Tăut, Adela; Pop, Dana; Sitar‐Tăut, Dan‐Andrei; Olteanu, Ileana; Zdrenghea, Dumitru

doi:10.1016/j.ejim.2010.06.001

Cited by 33 publications

(32 citation statements)

References 46 publications

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“…M235 exonic SNP (rs699), has been associated with body fat percentage and waist circumference but not BMI or WHR in Japanese women. Similar results were observed in Romanian female population, where rs699 was significantly associated with waist circumference, while the effects on BMI were only marginal (Procopciuc et al 2010). This was not confirmed for men in a larger Italian study (n = 959); however, the I/D polymorphism in the ACE gene was associated with waist circumference and its change during a 20-year follow-up, suggesting the importance of the renin-angiotensin system in this respect.…”

Section: Discussionsupporting

confidence: 80%

“…Genetic variants of the AGT gene have been repeatedly associated with a visceral pattern of obesity and metabolic syndrome in different populations (Takakura et al 2006;Procopciuc et al 2010). The AGT secretion has been found to be influenced by regulatory polymorphisms of the AGT gene, as is ?11525 C/A (rs7079) in miR-31 and another miRNA, miR-584, binding site.…”

Section: Introductionmentioning

confidence: 99%

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Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

et al. 2015

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Angiotensinogen (AGT), its active fragments and microRNA-31 (miR-31) play an important role in adipocyte differentiation. AGT contains a miR-31 polymorphic binding site. We hypothesize that the rs7079 polymorphism in the miR-31/584 binding site of the AGT gene could influence body fat distribution. A total of 751 subjects (195 men, 556 women) were enrolled in the study. The rs7079 genotypes were determined by qRT-PCR. Anthropometric measurements were taken on all subjects, who were subsequently divided into two groups: obese ([30 kg m -2 ) and non-obese (\30 kg m -2 ). Linear regression models were created to determine the contributions of sex, obesity status and rs7079 to all measured parameters. Adding the rs7079 genotype significantly contributed to the linear regression model for waist circumference (p = 0.013), hip circumference (p = 0.018) and supraspinal skin-fold thickness (p = 1 9 10 -3 ). Differences between sexes and between the obese and nonobese groups were observed. Waist circumference was lower in men carrying the A allele (p = 0.022); hip circumference was higher only in obese women carrying the A allele (p = 0.015). While men carrying the A allele had lower supraspinal skin-fold thickness (p = 0.022), this parameter was found to be higher in A allele carrying women (p = 3 9 10 -3 ). The higher total sum of skin-fold thickness in A allele carrying women was restricted to obese individuals (p = 0.028). The presence of the A allele was associated with both lower tricipital skin-fold thickness in non-obese women (p = 0.023) and a trend of higher thickness in non-obese men (p = 0.065). Significant associations of rs7079 in the AGT gene and body fat distribution were observed. The distribution followed opposing patterns in both sexes.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

et al. 2015

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“…2016;60/3 or sociocultural origins of the populations studied, as for the characteristics of the study design (9,(11)(12)(13)24). Insulin resistance is a key component of metabolic syndrome, hypertension and type 2 diabetes mellitus, which is related to RAS performance.…”

Section: Ras Polymorphisms In Mets Subjectsmentioning

confidence: 99%

“…This variant was described by Procopciuc and cols. as a conditioning factor for MetS due to the combination of the CC genotype (TT235) with DD of ACE, or CC+AC rs5186 (A1166C) genotypes increase the risk for developing MetS (13).…”

Section: Introductionmentioning

confidence: 99%

Association of polymorphisms within the Renin-Angiotensin System with metabolic syndrome in a cohort of Chilean subjects

Herrera

Castillo

Estrada

et al. 2016

Arch. Endocrinol. Metab.

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Objective: Metabolic syndrome (MetS) is associated with hypertension, obesity and dyslipidemia. Thus, genetic variants related with these conditions may modulate its development. We evaluated the effect of polymorphisms in the renin-angiotensin system (RAS) on metabolic syndrome risk in a cohort of Chilean subjects. Subjects and methods: A total of 152 subjects, 83 with MetS (51.2 ± 9.6 years) and 69 without MetS (49.5 ± 9.3 years) of both genders were included, according to the ATP III update criteria. The rs4340 Insertion/Deletion (I/D), rs699 (T>C) and rs5186 (A>C) of the ACE, AGT and AGTR1 genes, respectively, were genotyped. Results: After adjusting for age and gender, we observed the DD genotype of rs4340 associated with MetS (p = 0.02). Specifically, the DD genotype was associated with MetS risk in women (OR = 4.62, 95%CI, 1.41 -15.04; p < 0.01). In males, the AA genotype for rs5186 variant was associated with an increased risk for developing MetS when compared with women carrying the same genotype (OR = 3.2; 95%CI, 1.03 -9.89; p = 0.04). In subjects without MetS, DD genotype was associated with increased waist circumference (p = 0.023) while subjects with MetS carrying the rs5186 TT genotype showed higher levels of HDL-cholesterol (p = 0.031). Conclusion: The present study contributes data highlighting the role for RAS polymorphisms in predisposing to metabolic syndrome in Chilean subjects. Arch Endocrinol Metab. 2016;60(3):190-8

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“…В когорте шорцев генотипы С/С и Т/С коррелируют с различными метаболическими проявлениями (нарушениями липидного и углеводного обменов), в когорте некоренной национальности аналогичную корреляцию демонстрирует генотип Т/Т. Взаимо-связь генотипа С/С с различными метаболическими нарушениями (ожирением и дислипидемией) демон-стрируют исследования других популяций [10][11][12].…”

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Associations of the Angiotensin Gene Polymorphism (Agt, Rs699) With Systemic Hypertension and Its Risk Factors in Gornaya Shoria Inhabitants

et al. 2017

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Цель. Изучить распространенность полиморфизма гена aGt и его ассоциа-ции с риском развития артериальной гипертензии в этнических группах насе-ления Горной Шории. Материал и методы. Проведено клинико-эпидемиологическое исследова-ние компактно проживающего населения в труднодоступных районах Горной Шории (п. Ортон, п. усть-Кабырза) и поселке городского типа (п. Шерегеш). На основании поименных списков обследовано 1178 жителей указанных поселков. у 398 человек сплошным методом забрана кровь из кубитальной вены утром натощак для выполнения генотипирования. Выделение ДНК из крови проводилось методом фенол-хлороформной экстракции. Полимор-физм гена aGt (М235Т, rs699) тестировали с помощью ПЦР. Результаты. В целом в обеих этнических когортах распространенность гено-типов гена aGt значимо не различалась. Однако среди мужчин были установ-лены национальные особенности в отношении генотипа с/с: в группе шор-цев его частота (27,8%) была выше по сравнению с некоренными представи-телями (10,3%). В когорте шорцев у мужчин носителей генотипа Т/с отношения шансов выявления нарушений углеводного обмена и артериальной гипертен-зии составили, соответственно, 2,45, 2,21; у женщин, носителей генотипа с/с риск развития дислипидемии оказался равен 3,37. среди женщин некоренной национальности установлены ассоциации генотипа Т/Т с гиперхолестерине-мией. Отношение шансов выявить повышенный уровень общего холестерина среди носителей гомозиготного аллеля Т выше в 4,3 раза по сравнению с носителями генотипов Т/с и с/с. Заключение. Несмотря на отсутствие различий в распространенности гено-типов гена aGt, выявлены различия ассоциативной связи с факторами риска артериальной гипертензии в зависимости от этнической принадлежности. В когорте шорцев генотип с/с ассоциировался с гипербетахолестеринемией и дислипидемией, генотип Т/с -с нарушениями углеводного обмена. В когорте некоренной национальности генотип Т/Т ассоциировался с дисли-пидемией. Aim. to assess the prevalence of polymorphism of the gene aGt and its relation with systemic hypertension risk in the ethnicities of Gornaya shoria (Mountain shoriya). Material and methods.A clinical-epidemiological study conducted, of compactly inhabiting people of uneasily reachable areas of Gornaya shoria (settlements Orton, Ust-Kabyrza) and city-like settlement sheregesh. Based on the name lists, 1178 inhabitants included from the settlements. In 398 persons, blood was collected from cubital vein, fasting, in the morning for genotyping. extraction of DNA from the blood was done with phenol-chloroform method. Polymorphism of aGt (М235Т, rs699) gene was tested with PCR.Results. In general, in both ethnicities, the prevalence of aGt did not differ significantly. However, among men there was national specifics found for the C/C genotype: in the shortsy group its prevalence (27,8%) was higher comparing to non-native inhabitants (10,3%). In shortsy male cohort the carriers of t/C had odds ratio for glucose metabolism and arterial hypertension at 2,45 and 2,21, respectively; in females with C/C carriage the ...

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Renin angiotensin system polymorphisms in patients with metabolic syndrome (MetS)

Cited by 33 publications

References 46 publications

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

Association of polymorphisms within the Renin-Angiotensin System with metabolic syndrome in a cohort of Chilean subjects

Associations of the Angiotensin Gene Polymorphism (Agt, Rs699) With Systemic Hypertension and Its Risk Factors in Gornaya Shoria Inhabitants

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