Renin Angiotensin System (Ras) Blockade Attenuates Growth and Metastasis Formation of Renal Cell Carcinoma in Mice

Angiotensin System Inhibitors and Survival Outcomes in Patients with Metastatic Renal Cell Carcinoma

“…(36-38) Araujo and colleagues evaluated the losartan, captopril or the combination in vivo and demonstrated decreased tumor proliferation with renin-angiotensin system blockade. (36) Other studies demonstrated that captopril resulted in significant dose-related reduction in tumor development and candesartan dramatically prevented the development of metastatic lung nodules and inhibited neovascularization and VEGF expression in a RCC mouse xenograft model. (37, 38) Preclinical studies involving other cancer types have demonstrated similar effects with ASI treatment.…”

Renin Production by Juxtaglomerular Cell Tumors and Clear Cell Renal Cell Carcinoma and the Role of Angiotensin Signaling Inhibitors

“…In accordance with recent studies reporting that ASI use is associated with improved outcomes in hypertensive patients with metastatic RCC, the use of ACEIs and ARBs in our study was associated with improved PFS in hypertensive patients with nonmetastatic CC-RCC after radical or partial nephrectomy. 12 – 14 Further studies are warranted to corroborate this finding and to elucidate an underlying mechanism to determine whether angiotensin blockade may benefit patients with CC-RCC.…”

“… 9 – 11 This is of particular interest given recent reports of improved cancer-specific outcomes with the use of angiotensin signaling inhibitors (ASIs) in patients with metastatic renal cell carcinoma (RCC). 12 – 14 Indeed, several prior studies have suggested that the renin-angiotensin system can significantly affect the tumor microenvironment through the regulation of angiogenesis, inflammation, immunomodulation, and tumor fibrosis. 15 , 16 Signaling through angiotensin II and angiotensin II type 1 receptor is thought to promote vascular endothelial growth factor—mediated angiogenesis and oncogenesis, whereas the angiotensin II/angiotensin II type 2 receptor axis is thought to have a contrasting effect.…”