Reparative bone‐like tissue formation in the tooth of a systemic sclerosis patient

Matsuda, Shinji; Memida, Takumi; Mizuno, Noriyoshi; Ogawa, Ikuko; Ouhara, Kazuhisa; Kajiya, Mikihito; Fujita, Tsuyoshi; Sugiyama, Eiji; Kurihara, Hidemi

doi:10.1111/iej.12914

Cited by 6 publications

(13 citation statements)

References 17 publications

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“…Furthermore, the occlusal force of pt. 1 was 77.4 N in May 2019, and was weaker than that previously reported [12].…”

Section: Resultscontrasting

confidence: 66%

“…In the present study, MERR was detected in four SSc patients, including one described in a case report (pt. 1) [12]. The causes of external resorption, including trauma, periodontal and periapical inflammation, orthodontic treatment, internal bleaching or tumors, were not found in the teeth having external resorption.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the deposition of calcinosis in the nasal spur was noted in pts. 1, [12], 2, and 3, while calcinosis in the palatal plate was observed in pt. 4 (Figure 2c and Figure 3c).…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the fractured tooth in pt. 1 was histologically analyzed, and the findings obtained revealed that the fracture was repaired with bone-like tissue [12]. These findings suggest excessive bone formation in these patients is related to the resorption.…”

Section: Discussionmentioning

confidence: 99%

“…We and Arroyo-Bote and colleagues recently this reported multiple external root resorption (MERR) in SSc patients in Japan and Spain [12,13], respectively. These findings prompted us to examine MERR as a new manifestation of SSc.…”

Section: Introductionmentioning

confidence: 99%

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Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis—A Cross-Sectional Study in Japan

Memida

Matsuda

Kajiya

et al. 2019

JCM

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Background: Multiple external root resorption (MERR) has been reported in systemic sclerosis (SSc) patients in Japan and Spain. To establish whether MERR is a new manifestation, we investigated the prevalence of MERR and systemic and oral manifestations to be associated with MERR in patients with SSc. Methods: Root resorption was detected by dental X-rays, panoramagraphy or cone beam computed tomography (CBCT). The prevalence of systemic and oral manifestations was examined by rheumatologists and dentists, respectively. Autoantibodies were investigated using laboratory tests. Results: MERR was detected in four out of the 41 patients (9.8%) who participated in the present study. The prevalence of digital ulcers was significantly higher in patients with MERR (MERR vs. non-MERR, 75% vs. 16.2%, p < 0.05), whereas that of other systemic manifestations was not. The prevalence of face skin sclerosis (100% vs. 10.8%, p < 0.01), calcinosis at the facial region (75% vs. 0%, p < 0.01), limited mouth opening (75% vs. 18.9% p < 0.05), temporomandibular disorder symptoms (50% vs. 2.7%, p < 0.05), and tongue rigidity (75% vs. 2.7%, p < 0.05) was significantly higher in patients with MERR. Conclusion: SSc patients with MERR had highly homogenous maxillofacial manifestations. Further clinical and basic studies are needed to elucidate the mechanisms underlying MERR in SSc patients.

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“…Furthermore, the occlusal force of pt. 1 was 77.4 N in May 2019, and was weaker than that previously reported [12].…”

Section: Resultscontrasting

confidence: 66%

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the deposition of calcinosis in the nasal spur was noted in pts. 1, [12], 2, and 3, while calcinosis in the palatal plate was observed in pt. 4 (Figure 2c and Figure 3c).…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis—A Cross-Sectional Study in Japan

Memida

Matsuda

Kajiya

et al. 2019

JCM

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External cervical resorption detected via cone‐beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody–associated disease: A case report

Munenaga

Usuda

Ouhara

et al. 2021

Clinical Case Reports

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External cervical resorption may occur in patients with MOG antibody-associated disease. Herein, we present the first case in the literature. Cone-beam computed tomography is useful for the diagnosis of external cervical resorption in patients with MOG antibody-associated disease that would otherwise be undetected via radiography.Myelin oligodendrocyte glycoprotein (MOG) is the main protein component of the myelin sheath in the central nervous system (CNS). 1 MOG antibody-associated disease is a rare, autoimmune disorder that targets MOG, predominantly affecting the myelin in optic neuritis and myelitis, which can lead to vision loss and paralysis. Immunosuppressive therapies, such as steroids treatment, are often required for the treatment of MOG antibody-associated disease. 2,3 However,

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Cancellous bone-like tissue replacement from calcinosis in patients with systemic sclerosis with multiple external root resorption

et al. 2022

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Calcinosis is frequently observed in patients with systemic sclerosis (SSc). The fundamental treatment of calcinosis has not yet been established. During follow-up, calcinosis in the subcutaneous surface is often spontaneously extracted or remains confined by fibrous tissues. We previously identified a new symptom in SSc patients, multiple external root resorption (MERR), and these patients had calcifications in the nasal spine. Here, we report for the first time that calcinosis at the nasal spine in patients with MERR can be replaced by cancellous bone-like tissue. Patients 1 and 2 were a 62-year-old Japanese female and a 45-year-old Japanese female (respectively) with MERR who had been previously treated for SSc (Patient 1: limited type, positive for anti-centromere antibody; Patient 2: diffuse type, positive for anti-Scl70 and anti-SS-A antibodies). Patient 3 was a 57-year-old female with MERR who had been previously treated for SSc (diffuse type, positive anti-Scl-70 antibody) and underwent denosumab injection for osteoporosis. Cone-beam computed tomography (CBCT) and CT images in the calcifications at the nasal spine in Patient 1 and 2 were replaced with cancellous bone-like tissue, but not in Patient 3. Serum laboratory examination was performed to assess the systemic bone disease. All three patients had normal clinical data within the references, apart from slightly higher 1,25-dihydroxyvitamin D levels in Patient 1. SSc patients with calcinosis in the maxillofacial area need to be examined carefully for bone replacement using CBCT or CT.

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Reparative bone‐like tissue formation in the tooth of a systemic sclerosis patient

Cited by 6 publications

References 17 publications

Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis—A Cross-Sectional Study in Japan

Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis—A Cross-Sectional Study in Japan

External cervical resorption detected via cone‐beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody–associated disease: A case report

Cancellous bone-like tissue replacement from calcinosis in patients with systemic sclerosis with multiple external root resorption

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