Reparative Bone Regeneration at Use of Local Antibacterial Carriers in Purulent Osteomyelitis (Experimental Study)

Abstract

Efficacy of reinforcing local antibacterial carriers use upon the degree and terms of reparative regeneration of bone tissue defects resulted from osteomyelitis process was assessed in animal experiment (36 rabbits). In study group ( n =18) surgical treatment consisted of osteomyelitis focus salvage resection and installation of reinforcing local antibacterial carrier based on polymethyl methacrylate. In control group ( n =18) radical resection of the osteomyelitis focus with adjacent soft tissue structures was performed. In study group growth of microorganisms was not detected already on 28 th postoperative day while in control group the complete depression of pathogenic microflora was achieved only by day 50. Roentgenologic and morphologic data showed marked reparative regeneration in the zone of defect with formation of functionally mature callus under the effect of antibacterial carrier at terms up to 16 weeks.