Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

Abstract

NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide (NAD+) precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in blueberries. Here, we report this first-in-humans clinical trial designed to assess the safety and efficacy of a repeat dose of NRPT (commercially known as Basis). NRPT was evaluated in a randomized, double-blind, and placebo-controlled study in a population of 120 healthy adults between the ages of 60 and 80 years. The study consisted of three treatment arms: placebo, recommended dose of NRPT (NRPT 1X), and double dose of NRPT (NRPT 2X). All subjects took their blinded supplement daily for eight weeks. Analysis of NAD+ in whole blood demonstrated that NRPT significantly increases the concentration of NAD+ in a dose-dependent manner. NAD+ levels increased by approximately 40% in the NRPT 1X group and approximately 90% in the NRPT 2X group after 4 weeks as compared to placebo and baseline. Furthermore, this significant increase in NAD+ levels was sustained throughout the entire 8-week trial. NAD+ levels did not increase for the placebo group during the trial. No serious adverse events were reported in this study. This study shows that a repeat dose of NRPT is a safe and effective way to increase NAD+ levels sustainably.

Toward understanding genomic instability, mitochondrial dysfunction and aging

“…After supplementation with NAD + precursors, multiple beneficial effects have been observed, including improved mitochondrial health, increased muscle strength, and motor function . NAD + supplementation is being tested for various conditions (http://clinicaltrial.gov) and in studies so far, no side effects have been reported .…”

“…After supplementation with NAD + precursors, multiple beneficial effects have been observed, including improved mitochondrial health, increased muscle strength, and motor function [107,148,150,161]. NAD + supplementation is being tested for various conditions (clinical trial.gov) and in studies so far, no side effects have been reported [159,162]. NAD + is required for efficient DNA repair as it promotes the activities of PARP1, RecQ helicases, sirtuins, and many other DNA repair enzymes, and DNA repair accessory factors [25].…”

Aerobic and resistance exercise training reverses age‐dependent decline in NAD+salvage capacity in human skeletal muscle

“…Dietary supplementation of NR in rodents increases NAD + levels in skeletal muscle (Canto et al 2012), and improves skeletal muscle and muscle stem cell function in mice with aging or muscular dystrophy Zhang et al 2016). The potential effects of NR in human skeletal muscle are unknown, but dietary supplementation of NR in humans increases NAD + and NAD + -related metabolites in plasma, peripheral blood mononuclear cells, and urine Dellinger et al 2017;Dollerup et al 2018;Martens et al 2018).…”

Thoughts About Health Span

“…One study has shown, however, that the combination increases nicotinamide adenine dinucleotide blood levels in humans. 10 Despite the paucity of evidence, the combination is being sold as a supplement that targets longevity gene activation.…”