Repeat renal allografts treated with sirolimus, cyclosporine, anti‐thymocyte globulin induction and continuous steroids achieve similar immunosuppressive efficacy as primary transplants

BackgroundBlood transfusions have the potential to improve graft survival, induce sensitization, and transmit infections. Current clinical practice is to minimize transfusions in renal transplantation candidates, but it is unclear if the evidence continues to support pre-transplant transfusion avoidance. Changes in the Medicare prospective payment system may increase transfusion rates. Thus there is a need to re-evaluate the literature to improve the management options for renal transplant candidates.MethodsA review applying a systematic approach and conducted using MEDLINE®, Embase®, and the Cochrane Library for English-language publications (timeframe: 01/1984–03/2011) captured 180 studies and data from publically available registries and assessed the impact of transfusions on allosensitization and graft survival, and the impact of allosensitization on graft survival and wait time.ResultsBlood transfusions continued to be a major cause of allosensitization, with allosensitization associated with increased rejection and graft loss, and longer wait times to transplantation. Although older studies showed a beneficial effect of transfusion on graft survival, this benefit has largely disappeared in the post-cyclosporine era due to improved graft outcomes with current practice. Recent data suggested that it may be the donor-specific antibody component of allosensitization that carried the risk to graft outcomes.ConclusionsResults of this review indicated that avoiding transfusions whenever possible is a sound management option that could prevent detrimental effects in patients awaiting kidney transplantation.

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Repeat renal allografts treated with sirolimus, cyclosporine, anti‐thymocyte globulin induction and continuous steroids achieve similar immunosuppressive efficacy as primary transplants

Abstract: At 5 years this sirolimus regimen achieved similar efficacy for repeat versus primary transplantations.

Cited by 3 publications

References 29 publications

Genetically modified porcine split-thickness skin grafts as an alternative to allograft for provision of temporary wound coverage: preliminary characterization

Genetically modified porcine split-thickness skin grafts as an alternative to allograft for provision of temporary wound coverage: preliminary characterization

Preemptive Use of Mammalian Target of Rapamycin Inhibitors in Living Donor Transplantation

An update on the impact of pre-transplant transfusions and allosensitization on time to renal transplant and on allograft survival

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