Repeatability and comparability of peripapillary vessel density measurements of high-density and non-high-density optical coherence tomography angiography scans in normal and glaucoma eyes

Venugopal, Jayasree P.; Rao, Harsha L.; Weinreb, Robert N.; Dasari, Srilakshmi; Riyazuddin, Mohammed; Pradhan, Zia S.; Puttaiah, Narendra K.; Devi, Sathi; Mansouri, Kaweh; Webers, Carroll A.B.

doi:10.1136/bjophthalmol-2018-312401

Cited by 27 publications

(27 citation statements)

References 22 publications

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“…Venugopal et al. (,) also reported that SS of the scans had a significant effect on the short‐term repeatability of OCTA VDs. However, the differences in SS between the two measurements were the only significant factor in multivariate analysis.…”

Section: Discussionmentioning

confidence: 95%

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Long‐term repeatability of optical coherence tomography angiography parameters in healthy eyes

Lee

Nam

Lim

et al. 2019

Acta Ophthalmologica

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Purpose: To determine the long-term repeatability of optical coherence tomography angiography (OCTA) parameters in normal eyes. Methods: We prospectively enrolled 104 normal eyes. Participants were divided into three groups based on differences in the signal strength (SS) of OCTA scans obtained at two visits at least 6 months apart: group 1, SS difference = 2; group 2, 1; group 3, 0. We measured a foveal centred scan area of 3 3 3 mm pattern. All measurements were performed twice at 5-min intervals at the initial visit. The second measurements were performed at least 6 months later. Results: In short-term vessel density (VD) repeatability, the coefficient of variation (CV) ranged from 3.89% to 8.10% and the intraclass correlation coefficient (ICC) ranged from 0.785 to 0.941. In terms of long-term repeatability, the CV was 5.39-12.62% and the ICC was 0.598-0.867. In group 1, the ICCs of the inner and full VDs were 0.194 and 0.221, respectively. In groups 2 and 3, the ICCs of the inner and full VDs were 0.611 and 0.603, and 0.763 and 0.765, respectively. The central VDs of all groups had high CV besides high ICC.Conclusions: Optical coherence tomography angiography parameters showed good short-term and reasonable long-term repeatability in normal individuals. The differences in SSs between measurements affected such repeatability, so physicians should query the reliability of OCTA parameters when the differences in SS are 2 or more even when the SS is high.

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Section: Discussionmentioning

confidence: 95%

“…; Venugopal et al. ,). However, the long‐term repeatability of such parameters has not been reported as far as we know.…”

Section: Introductionmentioning

confidence: 99%

Long‐term repeatability of optical coherence tomography angiography parameters in healthy eyes

Lee

Nam

Lim

et al. 2019

Acta Ophthalmologica

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“…In addition to nailfold capillary alterations, the retina is another vulnerable organ to vascular dysregulation. Ganglion cell complex (GCC) thickness and RPC density are important indicators for detecting retinal ganglion cell (RGC) damage (Shin et al 2017; Venugopal & Rao 2018; Venugopal & Rao 2019). In this study, parafoveal GCC thickness was positively related to nailfold capillary density in POAG eyes.…”

Section: Discussionmentioning

confidence: 99%

Relationship between nailfold capillary morphology and retinal thickness and retinal vessel density in primary open‐angle and angle‐closure glaucoma

Rong

Cai

Mei

et al. 2020

Acta Ophthalmologica

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To compare the morphological characteristics of the nailfold capillaries in glaucoma patients with those in healthy subjects. To evaluate the relationship of nailfold capillary morphology with retinal thickness and retinal vessel density in patients with primary open-angle (POAG) and primary angleclosure glaucoma (PACG). Methods: Fifty-one patients with normal-tension glaucoma, thirty-two patients with hypertension glaucoma, thirty-two PACG patients and sixty-one healthy subjects were included in this cross-sectional study. Patients with connective tissue diseases or taking anticoagulation or antiplatelet agents were excluded. Nailfold capillaroscopy, spectral-domain optical coherence tomography and optical coherence tomography angiography were used to evaluate the nailfold capillary morphology, retinal thickness and retinal vessel density, respectively. Results: Nailfold capillary morphological features, including lower capillary density, greater tortuosity, more dilated capillaries >50 lm and more avascular zones >100 lm, were more common in POAG and PACG patients than in control subjects (all p < 0.001). In the POAG group, nailfold vessel density was negatively correlated with ganglion cell complex (GCC) thickness (odds ratio [OR] = 0.908, p = 0.010) and radial peripapillary capillary (RPC) density (OR = 0.787, p = 0.025). Tortuosity degree was negatively associated with RPC density (OR = 0.804, p = 0.016). In the PACG group, no evident relationship between nailfold capillary morphology and retinal thickness or retinal vessel density was detected (all p > 0.05). Conclusions: Nailfold capillary bed abnormalities were observed in both POAG and PACG patients. The nailfold capillary features, especially microvascular density and tortuosity degree, had a significant association with GCC thickness and RPC density in subjects with POAG but not in those with PACG.

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“…[13][14][15] Moreover, quantitative OCTA measurements have high repeatability. 16,17 Studies using OCTA have shown that glaucoma patients have significantly lower ocular perfusion than healthy subjects, 18 and decreased VD was correlated with axial length (AL) elongation. 19,20 Furthermore, lower VD, measured by OCTA, was associated with more severe glaucomatous visual field (VF) damage in highly myopic eyes, 21,22 and a larger FAZ area was associated with both glaucoma and high myopia.…”

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confidence: 99%

Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study

Lin

Gao

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To characterize longitudinal changes in macular microvasculature as quantified from optical coherence tomography angiography (OCTA) metrics in primary open-angle glaucoma (POAG) eyes with and without high myopia. METHODS.In total, 63 and 61 POAG eyes with and without high myopia, respectively, underwent swept-source OCTA imaging in at least four follow-up visits at an ophthalmic center, with a scanning protocol of 3-× 3-mm centered at the fovea. The foveal avascular zone (FAZ) area, FAZ circularity, and vessel density (VD) in both the superficial (SCP) and deep capillary plexuses (DCP) were measured. The rate of change in macular OCTA metrics over time was estimated using linear mixed-effects models in both groups of POAG eyes.RESULTS. The mean follow-up time and number of visits were 27.72 ± 8.57 months and 8.5 (8 to 13) times, and 30.95 ± 10.19 months and 10 (8-13) times in POAG eyes with and without high myopia, respectively. VD in the DCP reduced significantly more quickly in POAG eyes with high myopia than in those without high myopia (−5.14%/year vs. −3.71%/year, P = 0.008). Moreover, lower baseline VD in the DCP was significantly associated with faster VD reduction in POAG with high myopia eyes (P < 0.001). Conversely, the VD reduction rate in the SCP, FAZ area, and FAZ circularity in both the SCP and DCP were similar in both groups (all Ps > 0.05). CONCLUSIONS.VD in DCP reduced significantly more quickly in POAG eyes with high myopia over time. Density in the DCP reduced more quickly when baseline VD was low.

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Repeatability and comparability of peripapillary vessel density measurements of high-density and non-high-density optical coherence tomography angiography scans in normal and glaucoma eyes

Cited by 27 publications

References 22 publications

Long‐term repeatability of optical coherence tomography angiography parameters in healthy eyes

Long‐term repeatability of optical coherence tomography angiography parameters in healthy eyes

Relationship between nailfold capillary morphology and retinal thickness and retinal vessel density in primary open‐angle and angle‐closure glaucoma

Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study

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