Repeatability and Internal Consistency of Abdominal 2D and 4D Phase Contrast MR Flow Measurements

Wentland, Andrew L.; Grist, Thomas M.; Wieben, Oliver

doi:10.1016/j.acra.2012.12.019

Cited by 73 publications

(63 citation statements)

References 18 publications

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“…However, 4D-flow MR imaging flow measurements were previously and extensively validated in flow phantoms and in vivo compared with two-dimensional phase-contrast MR imaging, Doppler US, and animal studies (25–31). In the human abdomen, 4D-flow MR imaging was validated on the basis of conservation of mass principles (16,27). It should also be noted that invasive pressure measurements were not performed, a limitation that should be addressed in future studies.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Monitoring of Hepatic Blood Flow before and after TIPS by Using 4D-Flow MR Imaging

Bannas¹,

Roldán‐Alzate²,

Johnson³

et al. 2016

Radiology

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Purpose To demonstrate the feasibility of four-dimensional (4D)– flow magnetic resonance (MR) imaging for noninvasive longitudinal hemodynamic monitoring of hepatic blood flow before and after transjugular intrahepatic portosystemic shunt (TIPS) placement. Materials and Methods The institutional review board approved this prospective Health Insurance Portability and Accountability Act compliant study with written informed consent. Four-dimensional–flow MR imaging was performed in seven patients with portal hypertension and refractory ascites before and 2 and 12 weeks after TIPS placement by using a time-resolved three-dimensional radial phase-contrast acquisition. Flow and peak velocity measurements were obtained in the superior mesenteric vein (SMV), splenic vein (SV), portal vein (PV), and the TIPS. Flow volumes and peak velocities in each vessel, as well as the ratio of in-stent to PV flow, were compared before and after TIPS placement by using analysis of variance. Results Flow volumes significantly increased in the SMV (0.24 L/ min; 95% confidence interval [CI]: 0.07, 0.41), SV (0.31 L/min; 95% CI: 0.07, 0.54), and PV (0.88 L/min; 95% CI: 0.06, 1.70) after TIPS placement (all P < .05), with no significant difference between the first and second post-TIPS placement acquisitions (all P > .11). Ascites resolved in six of seven patients. In those with resolved ascites, the TIPS-to-PV flow ratio was 0.8 ± 6 0.2 and 0.9 ± 0.2 at the two post-TIPS time points, respectively, while the observed ratios were 4.6 and 4.3 in the patient with refractory ascites at the two post-TIPS time points, respectively. In this patient, 4D-flow MR imaging demonstrated arterio-portal-venous shunting, with draining into the TIPS. Conclusion Four-dimensional–flow MR imaging is feasible for noninvasive longitudinal hemodynamic monitoring of hepatic blood flow before and after TIPS placement.

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Section: Discussionmentioning

confidence: 99%

Longitudinal Monitoring of Hepatic Blood Flow before and after TIPS by Using 4D-Flow MR Imaging

Bannas¹,

Roldán‐Alzate²,

Johnson³

et al. 2016

Radiology

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“…Test-retest and inter-observer reproducibility for flow and WSS have been investigated for both 2D PC-MRI (29,30) and 4D flow techniques (30,31); however, few have looked in detail at WSS in the context of retest and inter-observer error with 4D flow (17,23). To our knowledge, this is the only study to have investigated the retest and observer variability of a volumetric 3D WSS computational algorithm, as presented here.…”

Section: Discussionmentioning

confidence: 99%

Reproducibility and interobserver variability of systolic blood flow velocity and 3D wall shear stress derived from 4D flow MRI in the healthy aorta

Ooij

Powell

Potters

et al. 2015

J. Magn. Reson. Imaging

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Purpose To investigate the reproducibility and inter-observer variability of 3D aortic velocity vector fields and wall shear stress (WSS) averaged over five systolic timeframes derived from non-contrast 4D-flow-MRI. Methods Fourteen controls underwent test-retest 4D-flow-MRI examinations separated by 16±3 days (resolution=3.0–3.6×2.3–2.6×2.5–2.7mm3; TE/TR/FA=2.5ms/4.9ms/7°; Venc=150cm/s). Two observers was segmented the aorta, and WSS was calculated for both series of scans and both segmentations. Test-retest and inter-observer velocity and WSS vectors were compared on a voxel-by-voxel basis in the aorta and on a regional basis by subdividing the aortas in six segments. Results Test-retest: voxel-by-voxel Bland-Altman analysis revealed small differences (−0.03/−0.02 m/s/Pa), limits of agreement of 0.25 m/s/0.29 Pa and coefficients of variation (CV) of 20% for velocity/WSS. Voxel-by-voxel orthogonal regression analysis showed moderate agreement (Slope: 1.14/1.16, Intraclass Correlation Coefficient (ICC): 0.76/0.67 for velocity/WSS). The regional analysis revealed a CV of 9%/8% and ICC of 0.9/0.9 for velocity/WSS. Inter-observer: voxel-by-voxel difference for WSS was 0, LOA: 0.17/0.19 Pa, CV: 12/13%, slope: 1.01/1.09, ICC: 0.87/0.85 for test/retest. The CV/ICC for WSS in the regional analysis was 4%/1.0 for test and 3%/1.0 for retest. Conclusions Systolic velocity and WSS derived from 4D flow MRI are reproducible between consecutive visits, with low inter-observer variability in healthy volunteers.

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“…Although pulse sequences for 4D flow MRI continue to be developed, its accuracy and test-retest reliability have been and are constantly seen in various phantom and in vivo studies [17, 24, 52–54]. Even though our institution is actively using 4D flow MRI clinically for different complex hemodynamic pathologic abnormalities, the 4D flow MRI techniques used on the clinical cases described in this article are not commonly available on routine clinical MRI systems.…”

Section: Discussionmentioning

confidence: 99%

“…Velocity information acquired with 4D flow MRI can be used to derive various flow-related parameters, including pulse wave velocity, pressure gradients, and wall shear stress [16]. Several studies have been performed to validate 4D flow MRI by comparing it with 2D phase-contrast MRI [17], laser Doppler velocimetry [18], and ultrasound flow measurements in different vascular territories [7, 19]. …”

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confidence: 99%

Emerging Applications of Abdominal 4D Flow MRI

Roldán‐Alzate

François

Wieben

et al. 2016

American Journal of Roentgenology

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OBJECTIVE Comprehensive assessment of abdominal hemodynamics is crucial for many clinical diagnoses but is challenged by a tremendous complexity of anatomy, normal physiology, and a wide variety of pathologic abnormalities. This article introduces 4D flow MRI as a powerful technique for noninvasive assessment of the hemodynamics of abdominal vascular territories. CONCLUSION Four-dimensional flow MRI provides clinicians with a more extensive and straightforward approach to evaluate disorders that affect blood flow in the abdomen. This review presents a series of clinical cases to illustrate the utility of 4D flow MRI in the comprehensive assessment of the abdominal circulation.

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Repeatability and Internal Consistency of Abdominal 2D and 4D Phase Contrast MR Flow Measurements

Cited by 73 publications

References 18 publications

Longitudinal Monitoring of Hepatic Blood Flow before and after TIPS by Using 4D-Flow MR Imaging

Longitudinal Monitoring of Hepatic Blood Flow before and after TIPS by Using 4D-Flow MR Imaging

Reproducibility and interobserver variability of systolic blood flow velocity and 3D wall shear stress derived from 4D flow MRI in the healthy aorta

Emerging Applications of Abdominal 4D Flow MRI

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