2010
DOI: 10.2967/jnumed.110.077255
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Repeatability of Metabolically Active Volume Measurements with18F-FDG and18F-FLT PET in Non–Small Cell Lung Cancer

Abstract: In addition to tumor size measurements with CT, there is a need for quantitative measurements of metabolic active volumes, possibly adding to tracer uptake measurements in oncologic response evaluation with PET. The aim of this study was to evaluate the metabolic volume test-retest variability in 18 F-FDG and 39-deoxy-39-18 F-fluorothymidine ( 18 F-FLT) PET studies for various commonly used volumes of interest (VOIs) and the dependence of that variability on lesion size and relative radiotracer uptake. Methods… Show more

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Cited by 101 publications
(109 citation statements)
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“…However, MTV in the present study was determined using an essentially fully automated delineation algorithm. Although several viable automated algorithms have been published (18)(19)(20)(21)(22)(23)(24)(25)(26)(27), in many institutions MTV is presently still determined by manual delineation. Manual delineation is known to be prone to intraand interobserver variability as well as to potentially gross size and background-dependent bias if fixed absolute or relative thresholds are used.…”
Section: Discussionmentioning
confidence: 99%
“…However, MTV in the present study was determined using an essentially fully automated delineation algorithm. Although several viable automated algorithms have been published (18)(19)(20)(21)(22)(23)(24)(25)(26)(27), in many institutions MTV is presently still determined by manual delineation. Manual delineation is known to be prone to intraand interobserver variability as well as to potentially gross size and background-dependent bias if fixed absolute or relative thresholds are used.…”
Section: Discussionmentioning
confidence: 99%
“…15 Baseline repeatability was quantified with the intraclass correlation coefficient. 10 Intratreatment change in the SUV was compared with baseline differences in SUV. The paired t test was used to determine whether there were statistically significant differences between these 2 measurements.…”
Section: Discussionmentioning
confidence: 99%
“…In practice, using such small changes to signify treatment response should be viewed with caution, for it is known that PET scans repeated days or even hours apart without intervening treatment can vary considerably in terms of SUV. [9][10][11][12][13] The significance of this phenomenon is that change observed during the course of treatment must be greater than inherent baseline variability to correctly attribute the observed change to the treatment itself. Intrinsic variability of SUV in the absence of treatment reflects biologic, technical, and observer variation.…”
mentioning
confidence: 99%
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“…However, no tracer is conclusively superior in the management of cancer. Serial PET scans have been used in clinical studies in patients [1][2][3][4][5][6][7] and preclinical researches in animal models [8][9][10][11][12][13][14] to study the uptake mechanism of the tracers. However, the results have been mixed.…”
Section: Introductionmentioning
confidence: 99%