Repeatability of Peripapillary Retinal Nerve Fiber Layer and Inner Retinal Thickness Among Two Spectral Domain Optical Coherence Tomography Devices

Matlach, Juliane; Wagner, Martin; Malzahn, Uwe; Göbel, Werner

doi:10.1167/iovs.14-15072

Cited by 51 publications

(29 citation statements)

References 27 publications

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“…Our study made it also possible to evaluate the SLO based image alignment function of the RS-3000 OCT. Though the repeatability figures for the various TR thickness parameters were highly satisfactory, the corresponding figures for cpRNFL thickness were relatively low, even when compared to published results obtained with other OCT systems [ 23 , 25 , 29 ]. Since the same images were used to calculate the CV and ICC values for all parameters including those which were highly reproducible, we think that the image alignment function used by us is clinically useful, and cannot be considered as the reason of the lower repeatability of the cpRNFL thickness parameters compared to cpTR thickness.…”

Section: Discussionmentioning

confidence: 54%

Differences of Intrasession Reproducibility of Circumpapillary Total Retinal Thickness and Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements Made with the RS-3000 Optical Coherence Tomograph

et al. 2015

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PurposeTo evaluate the intrasession reproducibility of various thickness parameters used to diagnose and follow-up glaucoma, in particular circumpapillary total retinal thickness (cpTR) provided by the RS-3000 optical coherence tomograph (OCT).MethodsFifty-three healthy eyes of 28 subjects underwent three consecutive imaging with the RS-3000 Advance OCT (NIDEK, Aichi,Japan) to evaluate the intrasession reproducibility of circumpapillary total retinal thickness (cpTR), circumpapillary retinal nerve fiber layer thickness (cpRNFL), macular ganglion cell complex thickness (mGCC) and macular total retina thickness (mTR) measurements. Intraclass correlation (ICC), coefficient of variation (CV) and reproducibility coefficient (RC) were calculated for each parameter.ResultsThe ICC and CV values for mean cpTR and cpRNFL were 0.987 and 0.897, and 0.60% and 2.81%, respectively. The RC values for the mean cpTR and cpRNFL were 5.95 μm and 9.04 μm, respectively. For all cpTR parameters the ICC values were higher and both the CV and RC values were lower than those for the corresponding cpRNFL parameters. The ICC and CV values for superior mGCC, inferior mGCC, superior mTR and inferior mTR were 0.983, 0.980, 0.983 and 0.988, and 0.84%, 0.98%, 0.48% and 0.43%, respectively. The RC values for superior mGCC, inferior mGCC, superior mTR and inferior mTR were 2.86 μm, 3.12 μm, 4.41μm and 4.43 μm, respectively.ConclusionsIntrasession reproducibility of cpTR, mGCC and mTR measurements made on healthy eyes was high. Repeatability of cpTR measurements was better than that of the corresponding cpRNFL measurements. These results suggest that future clinical investigations addressing detection of glaucoma and glaucomatous progression with the RS-3000 OCT may benefit from focusing on the cpTR parameters.

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Section: Discussionmentioning

confidence: 54%

Differences of Intrasession Reproducibility of Circumpapillary Total Retinal Thickness and Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements Made with the RS-3000 Optical Coherence Tomograph

et al. 2015

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“…The use of optical coherence tomography (OCT) to examine the retinal nerve fiber layer (RNFL) has become essential in daily clinical practice. Several studies have shown the OCT clinical usefulness to study many retinal and optic nerve diseases [1,2], along with its excellent reproducibility [3].…”

Section: Introductionmentioning

confidence: 99%

Changes in retinal nerve fiber layer thickness measurements in response to a trifocal intraocular lens implantation

García-Bella

Talavero-González

Carballo-Álvarez

et al. 2018

Eye

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“…Commercially available OCT systems are able to capture high-resolution, three-dimensional (3D) volumes of the retina and its sublayers 15,16. The propriety software automatically measures the thickness of pRNFL15,16 and GCIPL in sectors defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) 15,17. The diagnostic value of these core measurements is well documented;16 yet, other intraretinal layers provided additional and complimentary information regarding the health of the retina 18.…”

Section: Introductionmentioning

confidence: 99%

The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

Tan¹,

Ye²,

Jiang³

et al. 2016

OPTH

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PurposeTo determine the repeatability and profiles with different partition methods in intraretinal thickness layers in healthy human subjects, using optical coherence tomography (OCT).MethodsA custom-built ultrahigh-resolution OCT was used to acquire three-dimensional volume of the macula in 20 healthy subjects. The dataset was acquired twice using the macular cube 512×128 protocol in an area of 6×6 mm2 centered on the fovea. Commercially available segmentation software (Orion™) was used to segment the dataset into thickness maps of six intraretinal layers. The coefficient of repeatability and intraclass coefficient of correlation (ICC) were analyzed using hemispheric zoning and sectors defined by the Early Treatment Diabetic Retinopathy Study (ETDRS).ResultsAll datasets were successfully segmented to create six thickness maps of individual intraretinal layers. Coefficients of repeatabilities of these layers in hemispheric zones ranged from 0.9 to 6.6 µm, with an average of 3.6 µm (standard deviation [SD] 1.4), which was not significantly different compared to ETDRS sectors (P>0.05). ICCs of these layers in hemispheric zones ranged from 0.68 to 0.99, with an average of 0.91 (SD 0.07). There were no significant differences in ICCs between two zoning methods (P>0.05). Significant variations of tomographic intraretinal thicknesses were found between the inner and outer annuli and among the quadrantal sectors within the inner and outer annuli (P<0.05). Significant variations of the quadrantal sectors including both inner and outer annuli were evident in intraretinal layers (P<0.05) except for the outer plexiform layer.ConclusionThe measurement repeatabilities of tomographic thicknesses of intraretinal layers are comparable using both hemispheric and ETDRS partitions in volumetric data combined with the commercially available segmentation software. In keeping with known, normal anatomical variation, significant differences in tomographic thickness in various intraretinal layers were apparent in both hemispheric and ETDRS sectors.

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Repeatability of Peripapillary Retinal Nerve Fiber Layer and Inner Retinal Thickness Among Two Spectral Domain Optical Coherence Tomography Devices

Cited by 51 publications

References 27 publications

Differences of Intrasession Reproducibility of Circumpapillary Total Retinal Thickness and Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements Made with the RS-3000 Optical Coherence Tomograph

Differences of Intrasession Reproducibility of Circumpapillary Total Retinal Thickness and Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements Made with the RS-3000 Optical Coherence Tomograph

Changes in retinal nerve fiber layer thickness measurements in response to a trifocal intraocular lens implantation

The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

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