Repeatability of quantitative metrics derived from MR diffusion tractography in paediatric patients with epilepsy

Paldino, Michael J.; Hedges, Kara; Rodrigues, K M; Barboriak, Daniel P.

doi:10.1259/bjr.20140095

Cited by 11 publications

(14 citation statements)

References 53 publications

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“…Absence versus presence of the arcuate fasciculus has recently been shown to be highly reliable; this finding adds to its appeal as a potential biomarker. 25 Formation of association pathways involves numerous developmental processes that act in a coordinated fashion to establish mature patterns of cerebral connectivity. These include, but are not limited to, differentiation and maturation of pyramidal cells in cortical layer 3, axonal genesis and guidance to the subplate, synapse formation and establishment of connectivity with the developing cortical plate, and selection (or pruning) of connections.…”

Section: Discussionmentioning

confidence: 99%

“…This method has been shown previously to provide a highly reliable classification of the arcuate fasciculus with respect to its absence versus presence. 25 Mean fractional anisotropy and mean diffusivity were then calculated for each identifiable arcuate fasciculus.…”

Section: Image Processing and Analysismentioning

confidence: 99%

“…24 Together with recent work demonstrating that absence of the arcuate fasciculus at diffusion tractography is a highly reproducible binary finding, these results make the arcuate a very attractive target as a potential imaging marker of language function. 25 Hence, the goal of this study was to define the relationship between the arcuate fasciculi at diffusion tractography and the function of the language network in pediatric patients with MCD.…”

mentioning

confidence: 99%

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The Arcuate Fasciculus and Language Development in a Cohort of Pediatric Patients with Malformations of Cortical Development

Paldino

Hedges

Golriz

2015

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

Section: Image Processing and Analysismentioning

confidence: 99%

mentioning

confidence: 99%

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The Arcuate Fasciculus and Language Development in a Cohort of Pediatric Patients with Malformations of Cortical Development

Paldino

Hedges

Golriz

2015

AJNR Am J Neuroradiol

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“…Previous studies have looked into the inter-user reproducibility of tractography, noting that user performance is an important limiting factor. However, most studies assessed reproducibility in relation to apparent diffusion coefficient, fractional anisotropy, mean diffusivity, turning angle threshold, and streamline or voxel count [25][26][27][28][29]. More recently, a study looked at optimizing the number of selected streamlines through mathematical models aiming to reduce the reproducibility of probabilistic tractography but did not consider the influence of user-dependent choices [30].…”

Section: Discussionmentioning

confidence: 99%

Reproducibility of MRI-based white matter tract estimation using multi-fiber probabilistic tractography: effect of user-defined parameters and regions

Brumer

Vita

Ashmore

et al. 2021

Magn Reson Mater Phy

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Objective There is a pressing need to assess user-dependent reproducibility of multi-fibre probabilistic tractography in order to encourage clinical implementation of these advanced and relevant approaches. The goal of this study was to evaluate both intrinsic and inter-user reproducibility of corticospinal tract estimation. Materials and methods Six clinical datasets including motor functional and diffusion MRI were used. Three users performed an independent tractography analysis following identical instructions. Dice indices were calculated to quantify the reproducibility of seed region, fMRI-based end region, and streamline maps. Results The inter-user reproducibility ranged 41–93%, 29–94%, and 50–92%, for seed regions, end regions, and streamline maps, respectively. Differences in streamline maps correlated with differences in seed and end regions. Good inter-user agreement in seed and end regions, yielded inter-user reproducibility close to the intrinsic reproducibility (92–97%) and in most cases higher than 80%. Discussion Uncertainties related to user-dependent decisions and the probabilistic nature of the analysis should be considered when interpreting probabilistic tractography data. The standardization of the methods used to define seed and end regions is a necessary step to improve the accuracy and robustness of multi-fiber probabilistic tractography in a clinical setting. Clinical users should choose a feasible compromise between reproducibility and analysis duration.

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“…The AF in each subject was categorized as present on the left only, on the right only, or bilaterally ( Figure 2 ). This assessment of the AF as present versus absent has been previously shown to be highly reproducible [ 26 ]. Mean MD and mean FA were then calculated for each identifiable AF.…”

Section: Methodsmentioning

confidence: 99%

Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria

Paldino

Hedges

Gaab

et al. 2015

Behavioural Neurology

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Background. Polymicrogyric cortex demonstrates interindividual variation with regard to both extent of dyslamination and functional capacity. Given the relationship between laminar structure and white matter fibers, we sought to define the relationship between polymicrogyria (PMG), intrahemispheric association pathways, and network function. Methods. Each arcuate fasciculus (AF) was categorized as present or absent. Language was characterized by a pediatric neurologist. The presence of dysplastic cortex in the expected anatomic locations of Broca's (BA) and Wernicke's areas (WA) was evaluated by two pediatric neuroradiologists blinded to DTI and language data. Results. 16 PMG patients and 16 age/gender-matched controls were included. All normative controls had an identifiable left AF. 6/7 PMG patients with dysplastic cortex within BA and/or WA had no left AF; PMG patients without involvement of these regions had a lower frequency of absence of the left AF (p < 0.006). All patients without a left AF had some degree of language impairment. PMG patients without a left AF had a significantly greater frequency of language impairment compared to those PMG patients with a left AF (p < 0.003). Conclusion. In patients with PMG (1) the presence of dysplastic cortex within WA and/or BA is associated with absence of the left AF and (2) absence of the left AF is associated with language impairment.

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Repeatability of quantitative metrics derived from MR diffusion tractography in paediatric patients with epilepsy

Abstract: Reproducibility of these metrics will aid in the design of future studies and might one day be used to guide management in patients with epilepsy.

Cited by 11 publications

References 53 publications

The Arcuate Fasciculus and Language Development in a Cohort of Pediatric Patients with Malformations of Cortical Development

The Arcuate Fasciculus and Language Development in a Cohort of Pediatric Patients with Malformations of Cortical Development

Reproducibility of MRI-based white matter tract estimation using multi-fiber probabilistic tractography: effect of user-defined parameters and regions

Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria

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