Repeated exposure to one song leads to a rapid and persistent decline in an immediate early gene's response to that song in zebra finch telencephalon

Mello, Claudio V.; Nottebohm, Fernando; Clayton, David F.

doi:10.1523/jneurosci.15-10-06919.1995

Cited by 256 publications

(180 citation statements)

References 41 publications

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“…However, in this study electrophysiological responses to the tutor song were not measured. In the short term, repeated exposure to a song leads to a waning of the IEG response in the NCM (27), consistent with a role for this region in the detection of stimulus familiarity, which is an important aspect of recognition memory (28).…”

Section: Discussionsupporting

confidence: 63%

Localized neuronal activation in the zebra finch brain is related to the strength of song learning

Bolhuis

Zijlstra

Boer-Visser

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

243

221

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Songbirds (Oscines) learn their songs from a tutor. It is not known where in the brain the memories of these learned sounds are stored. Recent evidence suggests that song perception in songbirds involves neuronal activation in brain regions that have not traditionally been implicated in the control of song production or song learning, notably the caudal part of the neostriatum (NCM) and of the hyperstriatum ventrale. Zebra finch males (Taeniopygia guttata castanotis) were reared without their father and exposed to a tape-recorded song during the sensitive period for song learning. When, as adults, they were reexposed to the tutor song, the males showed increased expression of the protein products of the immediate early genes egr-1 (ZENK) and c-fos in the NCM and caudal hyperstriatum ventrale, but not in the conventional ''song-control nuclei.'' The strength of the immediate early gene response (which is a reflection of neuronal activation) in the NCM correlated significantly and positively with the number of song elements that the birds had copied from the tutor song. These results show localized neural activation in response to tutor song exposure that correlates with the strength of song learning.

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Section: Discussionsupporting

confidence: 63%

Localized neuronal activation in the zebra finch brain is related to the strength of song learning

Bolhuis

Zijlstra

Boer-Visser

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

243

221

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“…Scale bar ϭ 2 mm. Mello et al, 1995). We found 10 of 21 subunits/subtypes with statistically significant differential expression in auditory areas relative to the surrounding cells of each of their subdivisions (asterisk in Fig.…”

Section: Unique Differential Expression In Vocal Brain Areasmentioning

confidence: 77%

Differential expression of glutamate receptors in avian neural pathways for learned vocalization

Wada

Sakaguchi

Jarvis

et al. 2004

J of Comparative Neurology

141

188

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Learned vocalization, the substrate for human language, is a rare trait. It is found in three distantly related groups of birds-parrots, hummingbirds, and songbirds. These three groups contain cerebral vocal nuclei for learned vocalization not found in their more closely related vocal nonlearning relatives. Here, we cloned 21 receptor subunits/subtypes of all four glutamate receptor families (AMPA, kainate, NMDA, and metabotropic) and examined their expression in vocal nuclei of songbirds. We also examined expression of a subset of these receptors in vocal nuclei of hummingbirds and parrots, as well as in the brains of dove species as examples of close vocal nonlearning relatives. Among the 21 subunits/subtypes, 19 showed higher and/or lower prominent differential expression in songbird vocal nuclei relative to the surrounding brain subdivisions in which the vocal nuclei are located. This included relatively lower levels of all four AMPA subunits in lMAN, strikingly higher levels of the kainite subunit GluR5 in the robust nucleus of the arcopallium (RA), higher and lower levels respectively of the NMDA subunits NR2A and NR2B in most vocal nuclei and lower levels of the metabotropic group I subtypes (mGluR1 and -5) in most vocal nuclei and the group II subtype (mGluR2), showing a unique expression pattern of very low levels in RA and very high levels in HVC. The splice variants of AMPA subunits showed further differential expression in vocal nuclei. Some of the receptor subunits/subtypes also showed differential expression in hummingbird and parrot vocal nuclei. The magnitude of differential expression in vocal nuclei of all three vocal learners was unique compared with the smaller magnitude of differences found for nonvocal areas of vocal learners and vocal nonlearners. Our results suggest that evolution of vocal learning was accompanied by differential expression of a conserved gene family for synaptic transmission and plasticity in vocal nuclei. They also suggest that neural activity and signal transduction in vocal nuclei of vocal learners will be different relative to the surrounding brain areas.

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“…Measurement of long-term response habituation in NCM, by both electrophysiology and the study of the song stimulation-induced up-regulation of ZENK, has suggested that this area might encode the long-lasting sensory memory of the TUT (31,40). Other experiments point to the fact that NCM and CM might be involved in short-term plasticity related to song discrimination (18,19,48). The greater representation of TUT and BOS revealed by fMRI in our experiments therefore might reflect an important aspect of the sensory memory for these developmentally salient familiar stimuli.…”

Section: Familiar Song Stimuli Show Selective Differential Topographymentioning

confidence: 99%

Functional MRI of the zebra finch brain during song stimulation suggests a lateralized response topography

Voss

Tabelow

Polzehl

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Electrophysiological and activity-dependent gene expression studies of birdsong have contributed to the understanding of the neural representation of natural sounds. However, we have limited knowledge about the overall spatial topography of song representation in the avian brain. Here, we adapt the noninvasive functional MRI method in mildly sedated zebra finches (Taeniopygia guttata) to localize and characterize song driven brain activation. Based on the blood oxygenation level-dependent signal, we observed a differential topographic responsiveness to playback of bird's own song, tutor song, conspecific song, and a pure tone as a nonsong stimulus. The bird's own song caused a stronger response than the tutor song or tone in higher auditory areas. This effect was more pronounced in the medial parts of the forebrain. We found left-right hemispheric asymmetry in sensory responses to songs, with significant discrimination between stimuli observed only in the right hemisphere. This finding suggests that perceptual responses might be lateralized in zebra finches. In addition to establishing the feasibility of functional MRI in sedated songbirds, our results demonstrate spatial coding of song in the zebra finch forebrain, based on developmental familiarity and experience.imaging ͉ learning ͉ memory B irdsong is studied as a model of vocal learning, perception, production, and motor abnormalities of speech (1, 2). There are interesting parallels between song development and speech development (3) and between auditory and vocal pathways in the songbird and human brain (4). Therefore, insights from experiments on songbirds may contribute to the understanding of auditory and vocal function in humans. For example, minimal models of speech dyspraxia (5) and dysfluencies such as stuttering are being developed in zebra finches (6). Zebra finches are capable of learning, producing, perceiving, and discriminating complex sound patterns. Birdsong in zebra finches consists of a sequence of distinctive sounds produced by males and is characterized by a consistent and reproducible acoustic profile. Song is learned by imitating the song of an adult conspecific tutor during a sensitive period of development (7-10). Recently, it has been shown that songbirds are able to learn recursive syntactic patterns, presumably a simple form of grammar (11), thus extending the potential applicability of the birdsong model to our understanding of the biological basis of languages. Several brain structures are required for learning, production, and perception of birdsong. It is known from electrophysiological studies that song learning nuclei, such as the lateral magnocellular nucleus of the anterior nidopallium (LMAN) and X (12), play an important role in song development. In parallel with song motor learning, auditory song selectivity gradually emerges during development (13-17). Robust sensory responses to auditory stimuli have been recorded in the primary auditory area in the caudal telencephalic region (field L), the caudomedial nidopallium (N...

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Repeated exposure to one song leads to a rapid and persistent decline in an immediate early gene's response to that song in zebra finch telencephalon

Cited by 256 publications

References 41 publications

Localized neuronal activation in the zebra finch brain is related to the strength of song learning

Localized neuronal activation in the zebra finch brain is related to the strength of song learning

Differential expression of glutamate receptors in avian neural pathways for learned vocalization

Functional MRI of the zebra finch brain during song stimulation suggests a lateralized response topography

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