Repeated Sauna Therapy Reduces Urinary 8-Epi-Prostaglandin F2.ALPHA.

Abstract

SUMMARYWe have reported that repeated sauna therapy improves impaired vascular endothelial function in a patient with coronary risk factors. We hypothesized that sauna therapy decreases urinary 8-epi-prostaglandin F 2α (PGF 2α ) levels as a marker of oxidative stress and conducted a randomized, controlled study. Twenty-eight patients with at least one coronary risk factor were divided into a sauna group (n = 14) and non-sauna group (n = 14). Sauna therapy was performed with a 60°C far infrared-ray dry sauna for 15 minutes and then bed rest with a blanket for 30 minutes once a day for two weeks.Systolic blood pressure and increased urinary 8-epi-PGF 2α levels in the sauna group were significantly lower than those in the non-sauna group at two weeks after admission (110 ± 15 mmHg vs 122 ± 13 mmHg, P < 0.05, 230 ± 67 pg/mg • creatinine vs 380 ± 101 pg/mg • creatinine, P < 0.0001, respectively). These results suggest that repeated sauna therapy may protect against oxidative stress, which leads to the prevention of atherosclerosis. ( diabetes mellitus, 3) and smoking. 4) Oxidative stress is also known to induce gene mutations and is related to carcinogenesis. 5) Therefore, effective control of oxidative stress is important for the prevention and treatment of such diseases. F 2 -isoprostanes, namely 8-epi-prostaglandin F 2α (8-epi-PGF 2α ), are chemically stable products of lipid peroxidation and the urinary 8-epi-PGF 2α level has been suggested to be a reliable marker of oxidative stress in vivo. 6)We have reported that repeated sauna therapy improved vascular endothelial function in patients with coronary risk factors such as hypertension, hyperlipidemia, diabetes mellitus, and smoking.7) Furthermore, we found that repeated sauna therapy upregulates mRNA and protein expression of arterial endothelial From the

Far Infrared Therapy Inhibits Vascular Endothelial Inflammation via the Induction of Heme Oxygenase-1

“…[17][18][19][20][21]29,30 In the present study, we extend these findings to show that FIR radiation exerts a potent antiinflammatory effect on vascular endothelium. We observed that FIR radiation inhibits the TNF-␣-mediated expression of the adhesion molecules VCAM-1, ICAM-1, and E-selectin, as well as the chemoattractants MCP-1 and IL-8.…”

Effect of Waon Therapy on Oxidative Stress in Chronic Heart Failure

“…24 We have reported that 2 weeks of Waon therapy decreased urinary concentrations of 8-epi-PGF2α, a marker of oxidative stress, in patients with at least one atherosclerotic risk factor. 13 However, the effect of Waon therapy on oxidative stress in CHF has not been elucidated. The purpose of the present study was to clarify the effect of Waon therapy on oxidative stress in CHF patients and address its mechanism using cardiomyopathic hamsters with heart failure.…”

“…12 In addition, we demonstrated that 2 weeks of Waon therapy significantly decreased urinary 8-epi-PGF2α levels in patients with at least 1 atherosclerotic risk factor, when compared to those of patients who did not undergo Waon therapy. 13 Thus, Waon therapy reduces oxidative stress and improves vascular function in patients with atherosclerotic risk factors.…”

Waon Therapy for Cardiovascular Disease: - Innovative Therapy for the 21st Century -

“…Urinary 8-epi-PGF2α levels were significantly decreased in the treated patients when compared with controls. 12 Thus, Waon therapy reduces oxidative stress and improves vascular function in patients with atherosclerosis risk factors.…”

“…11, 12 In this review, we summarize the beneficial effects of Waon therapy on cardiovascular disease.…”