Repeated vertebral augmentation for new vertebral compression fractures of postvertebral augmentation patients: a nationwide cohort study &amp;ndash; how useful is the current clinical gold standard for fracture risk?

Wilson, H.; Abel, Paul; Shah, Syed Imran Ali

doi:10.2147/cia.s96526

CIA

2015

DOI: 10.2147/cia.s96526

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Repeated vertebral augmentation for new vertebral compression fractures of postvertebral augmentation patients: a nationwide cohort study – how useful is the current clinical gold standard for fracture risk?

H. Wilson¹,

Paul Abel²,

Syed Imran Ali Shah³

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2018

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“…As osteoporosis is symptomless, silent and progressive, the need for an accurate fracture prediction model is crucial for effective patient management. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density (BMD) [3], using dual energy X-ray absorption (DEXA) [4]. However the use of BMD to diagnose osteoporosis is not without limitation, with a study by Wainwright reporting that 54% of new hip fractures occurred in women who did not have osteoporosis according to their BMD [5].…”

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confidence: 99%

Age-Related Changes in Femoral Head Trabecular Microarchitecture

Greenwood¹,

Clement²,

Dicken³

et al. 2018

Aging and disease

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Osteoporosis is a prevalent bone condition, characterised by low bone mineral density and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density using dual energy X-ray absorption. However, many studies have shown that bone strength, and consequently the probability of fracture, is a combination of both bone mass and bone ‘quality’ (architecture and material chemistry). Although the microarchitecture of both non-fracture and osteoporotic bone has been previously investigated, many of the osteoporotic studies are constrained by factors such as limited sample number, use of ovariectomised animal models, and lack of male and female discrimination. This study reports significant differences in bone quality with respect to the microarchitecture between fractured and non-fractured human femur specimens. Micro-computed tomography was utilised to investigate the microarchitecture of femoral head trabecular bone from a relatively large cohort of non-fracture and fracture human donors. Various microarchitectural parameters have been determined for both groups, providing an understanding of the differences between fracture and non -fracture material. The microarchitecture of non-fracture and fracture bone tissue is shown to be significantly different for many parameters. Differences between sexes also exist, suggesting differences in remodelling between males and females in the fracture group. The results from this study will, in the future, be applied to develop a fracture model which encompasses bone density, architecture and material chemical properties for both female and male tissues.

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mentioning

confidence: 99%

Age-Related Changes in Femoral Head Trabecular Microarchitecture

Greenwood¹,

Clement²,

Dicken³

et al. 2018

Aging and disease

View full text Add to dashboard Cite

show abstract

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Repeated vertebral augmentation for new vertebral compression fractures of postvertebral augmentation patients: a nationwide cohort study – how useful is the current clinical gold standard for fracture risk?

Cited by 1 publication

References 14 publications

Age-Related Changes in Femoral Head Trabecular Microarchitecture

Age-Related Changes in Femoral Head Trabecular Microarchitecture

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