Repetitively Negative Changing T Waves at 24-h Electrocardiographic Monitors in Patients With the Chronic Fatigue Syndrome

Immunoassay with cytomegalovirus early antigens from gene products p52 and CM2(UL44 and UL57) detects active infection in patients with chronic fatigue syndrome

“…Patients with raised serum titres to Borrelia burgdorferi or raised serum antibody titres to streptolysin 0 were also indistinguishable from the larger group of CFS patients. All CFS patients (96%, p<0.01) had abnormal oscillating T-waves indicative of CFS cardiomyopathy,21 22 and 19% had abnormal cardiac wall motion 16…”

An update on the management of glandular fever (infectious mononucleosis) and its sequelae caused by Epstein&ndash;Barr virus (HHV-4): new and emerging treatment strategies

“…Cardiac biopsy with electron microscopy demonstrated myofiber disarray without cellular infiltrates. [61][62][63][64] Focal interstitial fibrosis, myofiber drop-out, myofiber hypertrophy, and perimysial fat infiltration were present. EBV myocarditis, a complication of IM is documented.…”

“…The standard resting ECG is usually normal. 19,61 The greater the duration of CFS illness before valacyclovir treatment, the more likely it is that baseline standard ECG is abnormal. 64 Among 106 Group A CFS patients, 92 patients (88.5%) had abnormal baseline 24-hour ECG monitors (HM): 77 patients (74%) had abnormal oscillating T-wave flattening, 46 patients (44.2%) had abnormal oscillating T-wave inversions, and 47 patients (44.5%) had tachycardias at rest.…”

The Association Between Prolonged Fatigue and Cardiovascular Disease in World War II Veteran Twins

“…Efforts to understand long-term exhaustion or more rigorously defined forms of unexplained fatigue such as chronic fatigue syndrome are also of relevance here. The medical literature indicates that these conditions are not simply manifestations of underlying psychiatric disorders, but may involve autonomic dysfunction at the cardiac level as well as immunologic and infectious components (De Becker et al, 1998;Fukuda et al, 1994;Komaroff & Buchwald, 1998;Lerner et al, 1993). In fact, an association with cardiac dysfunction and chronic fatigue has been suggested in several studies.…”

“…In fact, an association with cardiac dysfunction and chronic fatigue has been suggested in several studies. Among 300 individuals who had worn a 24-hour Holter monitor, a significantly higher proportion of those with chronic fatigue had abnormalities consisting primarily of repetitively flat to inverted T-waves alternating with normal T-waves along with gross left ventricular dysfunction (Lerner et al, 1993). Others have observed that, compared to age-and sex-matched controls, patients with chronic fatigue syndrome had normal resting cardiac function but a markedly abbreviated exercise capacity characterized by slow acceleration of heart rate and fatigue of exercising muscles long before peak heart rate was achieved (Montague et al, 1989).…”