Replacement of nitro function by free boronic acid in non-steroidal anti-androgens

Šlechta, Petr; Viták, Roman; Bárta, Pavel; Koucká, Kateřina; Berková, Monika; Žďárová, Diana; Petríková, Andrea; Kuneš, Jiří; Kubíček, Vladimír; Doležal, Martin; Kučera, Radek; Kučerová-Chlupáčová, Marta

doi:10.1039/d4md00343h

RSC Med. Chem.

2024

DOI: 10.1039/d4md00343h

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Replacement of nitro function by free boronic acid in non-steroidal anti-androgens

Petr Šlechta,

Roman Viták,

Pavel Bárta

et al.

Abstract: A screen of 33 boronic acids identified molecules with antiproliferative activity against androgen-dependent prostate cancer cell line LAPC4. Structural similarity with NSAA raises a question whether nitro group could be substituted for boronic acid.

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Replacement of nitro function by free boronic acid in non-steroidal anti-androgens

Abstract: A screen of 33 boronic acids identified molecules with antiproliferative activity against androgen-dependent prostate cancer cell line LAPC4. Structural similarity with NSAA raises a question whether nitro group could be substituted for boronic acid.

Cited by 0 publications

References 43 publications

No citations

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