2008
DOI: 10.1038/ng.148
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Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

Abstract: Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.

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Cited by 332 publications
(310 citation statements)
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“…35,36 Association of two immediately flanking IRGM gene polymorphisms (rs13361189 and rs4958847) with CD has recently been reported. 17,30,37 Reduced activity of these genes would be expected to lead to persistence of intracellular bacteria, consistent with existing models of CD pathogenesis and the recent ATG16L1 and IRGM association reports.…”
Section: Introductionsupporting
confidence: 83%
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“…35,36 Association of two immediately flanking IRGM gene polymorphisms (rs13361189 and rs4958847) with CD has recently been reported. 17,30,37 Reduced activity of these genes would be expected to lead to persistence of intracellular bacteria, consistent with existing models of CD pathogenesis and the recent ATG16L1 and IRGM association reports.…”
Section: Introductionsupporting
confidence: 83%
“…[14][15][16][21][22][23][24][25][26][27][28][29][30][31][32][33][34]38,39 Funnel plots and Egger tests were performed to analyse the publication bias of the meta-analysis. No statistically significant values were observed in CD studies (P ¼ 0.6) or UC studies (P ¼ 0.4), with symmetric funnel plots for both studies (Supplementary Figure 1).…”
Section: Association Of Atg16l1 and Irgm With Ibd Rj Palomino-moralesmentioning
confidence: 99%
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