Reply by authors to discussion by S. K. Choudhury and R. Amaravadi

Abstract

We appreciate Messrs. Choudhury and Amaravadi’s interest in our paper and thank them for pointing out some typographical errors in the paper. In fact, we were aware of these and some other similar errors. To us, the corrections of these errors are quite obvious to any serious reader of the paper and they do not seem to deserve any special attention of the general readers of Geophysics. However, we take this opportunity to list them below.

Mice Fed a High‐Cholesterol Diet Supplemented with Quercetin‐3‐Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas

“…Excessive intracellular cholesterol renders in pancreatic beta cells dysfunctional. [19] In this study, mice under HCD remained euglycemic but became hyperinsulinemic, an indication that they were insulin resistant, as translated by their decreased GIR values. Histological analysis of their pancreatic islets revealed multiple oblong micro-vacuoles containing reddish crystalline deposits of unknown nature.…”

“…[18] Intracellular accumulation of cholesterol is known to deleteriously affect the endocrine function of β cells. [19] It is presumably a cause of the insulin-insufficiency and the prediabetes exhibited by PCSK9KO mice. [18,20] PCSK9 may therefore play a protective role in the pancreas.…”

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

“…Osmotic-type micropumps usually have two chambers ( Figure 3C). [100,102] One chamber serves as a drug reservoir containing drug solutions and the other chamber which is made up of a semipermeable membrane contains osmotic driving agents. These chambers are separated from each other by a flexible membrane or a piston.…”

Ethyl Lactate: A Green Solvent for Olefin Metathesis

“…[1,[7][8][9] However,according to our knowledge,there are very few reports on the application of LE as solvents in chemical synthesis. [10] Therefore, we decided to test ethyl lactate (EL), one of the simplest andc heapest lactic esters, in catalytic olefin metathesis. Olefinm etathesis is as elective and atom-economic chemicalt ransformation that offers ag reat promise in pharmaceuticala nd fine-chemical industries.…”