Reply: to Chronic venous ulcer treatment with topical sevoflurane by Imbernón <i>et al.</i>

Fernández-Ginés, FD; Cortiñas-Sáenz, Manuel; Aranda, Ana Navajas-Gómez de; Bocanegra, Rodrigo Yoldi; Sierra-García, F

doi:10.1111/iwj.12709

Cited by 5 publications

(13 citation statements)

References 4 publications

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“…Our results show that topical sevoflurane have an epithelising effect, diminishing the time to healing. In previous reports, a progressive diminishing of size and deepness of the ulcer treated with sevoflurane in successive cleanings along some weeks has been reported (15)(16)(17)(18)(19)(20)(21)(22)(23).…”

Section: Discussionmentioning

confidence: 91%

“…Topical sevoflurane has an intense, quick and long-lasting analgesic effect. The latency time varies between 1 and 10 minutes, and the duration ranges between 7 and 24 hours (15)(16)(17)(18)(19)(20)(21)(22)(23). Until now, we report the study with the highest number of patients with chronic venous ulcers treated with topical sevoflurane.…”

Section: Discussionmentioning

confidence: 99%

“…• chronic venous ulcers usually present with pain at rest and a limited cicatrisation • thirty patients older than 65 with painful refractory chronic venous ulcers have been treated with topical sevoflurane • topical sevoflurane has a fast, intense and long-lasting analgesic effect; it improves the ulcer-healing process and has an adequate safety profile of general anaesthesia in hospital and ambulatory surgery (14). Its efficacy has been reported in a few case reports as a topical anaesthetic in leg ulcers (15)(16)(17)(18)(19)(20)(21)(22)(23). Our purpose is to assess the efficacy and safety of topical sevoflurane in CVU and its impact on analgesia and healing.…”

Section: Key Messagesmentioning

confidence: 99%

“…Sevoflurane is an inhaled halogenated anaesthetic agent with an adequate safety profile, used for induction and maintenance of general anaesthesia in hospital and ambulatory surgery . Its efficacy has been reported in a few case reports as a topical anaesthetic in leg ulcers . Our purpose is to assess the efficacy and safety of topical sevoflurane in CVU and its impact on analgesia and healing.…”

Section: Introductionmentioning

confidence: 99%

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Healing of chronic venous ulcer with topical sevoflurane

Imbernón-Moya

Frutos

Sanjuan-Alvarez

et al. 2017

International Wound Journal

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The present study assesses the efficacy and safety of topical sevoflurane in chronic venous ulcers and its impact on analgesia and healing. This retrospective study included 30 patients older than 65 years with painful refractory chronic venous ulcers. Patients were treated with topical sevoflurane prior to the usual ulcer cleaning every 2 days for a period of 1 month. Treatment was initiated with a saline solution, followed by direct irrigation of 1 ml of liquid sevoflurane over the wound size, which was measured as cm . Sevoflurane had a fast, intense and long-lasting analgesic effect. Latency time ranged from 2 to 7 minutes (3·9 ± 1·5 minutes), and duration varied from 8 to 18 hours (12 ± 2·9). The mean ulcer size was 8·4 ± 9·7 cm . There was a progressive decrease in size in all patients, with a mean size of 4·2 ± 5·4 cm at the end of the study. There were no adverse systemic effects. Local adverse effects were mild and transient, including pruritus, erythema and heat. Topical sevoflurane is a new, efficient and safe therapeutic alternative in painful chronic venous ulcers, refractory to usual analgesic treatment. It can improve the ulcer-healing process that shortens the cicatrisation period.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Key Messagesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Healing of chronic venous ulcer with topical sevoflurane

Imbernón-Moya

Frutos

Sanjuan-Alvarez

et al. 2017

International Wound Journal

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“… 6 There have been a few case reports of its efficacy as a topical anaesthetic in leg ulcers. 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 …”

Section: Introductionmentioning

confidence: 99%

Pain, Quality of Life, and Functional Capacity With Topical Sevoflurane Application for Chronic Venous Ulcers: A Retrospective Clinical Study

Imbernón-Moya

Frutos

Sanjuan-Alvarez

et al. 2017

EJVES Short Reports

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IntroductionChronic venous ulcers (CVU) commonly have poorly controlled pain.ReportThirty patients older than 65 years of age with painful CVU were reviewed. At the initial visit, cleaning without sevoflurane was performed. Cleaning visits with sevoflurane every 2 days for 1 month were scheduled. The results of subsequent treatment with sevoflurane at the first, second, seventh, and twelfth cleanings were analysed. Pain was measured using a visual analog scale (VAS), quality of life by the Charing Cross Venous Leg Ulcer Questionnaire, and functional capacity by the Barthel Index.DiscussionInitial VAS was 8.8 ± 1.3 points and at the twelfth cleaning VAS was 0.8 ± 1 points (p = .001). Latency time ranged between 2 and 7 m and duration ranged between 8 and 18 h. It improved quality of life (83 ± 14 points before treatment vs. 50 ± 14 at the twelfth cleaning) and functional capacity (82 ± 13.3 before treatment vs. 91 ± 11.6 points at the twelfth cleaning) (p = .001). The safety profile was favourable with mild and self limited local cutaneous adverse effects, including pruritus, erythema, and heat. No systemic toxicity was detected. Topical sevoflurane may be a therapeutic alternative for painful CVU with a fast, intense, and long-lasting analgesic effect.

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Sevoflurane: Features and uses in topical application for wound care

Gerónimo-Pardo

2022

Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics

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Reply: to Chronic venous ulcer treatment with topical sevoflurane by Imbernón et al.

Cited by 5 publications

References 4 publications

Healing of chronic venous ulcer with topical sevoflurane

Healing of chronic venous ulcer with topical sevoflurane

Pain, Quality of Life, and Functional Capacity With Topical Sevoflurane Application for Chronic Venous Ulcers: A Retrospective Clinical Study

Sevoflurane: Features and uses in topical application for wound care

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