Reply to Comment on: Sideroblastic anemia associated with multisystem mitochondrial disorders

Tesařová, Markéta; Zeman, Jiřı́

doi:10.1002/pbc.28007

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…The PPI and gene network analyses identified PUS7 interacting partners, including NOC3L and PUS1, which are also not reported in ovarian cancer, although several reports have revealed that NOC3L regulates the proliferation and tumorigenesis of gastric cancer [ 41 ], and NOC3L is associated with an increased risk of gastric cancer in the Chinese Han population [ 42 ]. For PUS1, previous reports demonstrated that it is related to sideroblastic anemia [ 43 ], and no association of PUS1 with cancer was ever shown, suggesting the novelty of the protein interaction. To further explore the signaling pathway of PUS7 in ovarian cancer, the GSEA pathways analysis demonstrated that DNA replication and the cell cycle are the top two pathways that PUS7 regulated.…”

Section: Discussionmentioning

confidence: 99%

The Identification of RNA Modification Gene PUS7 as a Potential Biomarker of Ovarian Cancer

Chen

Han

et al. 2021

Biology

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RNA modifications are reversible, dynamically regulated, and involved in a variety of diseases such as cancers. Given the lack of efficient and reliable biomarkers for early diagnosis of ovarian cancer (OV), this study was designed to explore the role of RNA modification genes (RMGs) in the diagnosis of OV. Herein, 132 RMGs were retrieved in PubMed, 638 OV and 18 normal ovary samples were retrieved in The Cancer Genome Atlas (TCGA), and GSE18520 cohorts were collected for differential analysis. Finally, PUS7 (Pseudouridine Synthase 7) as differentially expressed RMGs (DEGs-RMGs) was identified as a diagnostic biomarker candidate and evaluated for its specificity and sensitivity using Receiver Operating Characteristic (ROC) analysis in TCGA and GEO data. The protein expression, mutation, protein interaction networks, correlated genes, related pathways, biological processes, cell components, and molecular functions of PUS7 were analyzed as well. The upregulation of PUS7 protein in OV was confirmed by the staining images in HPA and tissue arrays. Collectively, the findings of the present study point towards the potential of PUS7 as a diagnostic marker and therapeutic target for ovarian cancer.

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Section: Discussionmentioning

confidence: 99%