Reply to “In reference to preoperative serum biomarkers in the prediction of postoperative delirium following abdominal surgery”

Ida, Mitsuru; Takeshita, Yuna; Kawaguchi, Masahiko

doi:10.1111/ggi.14216

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…The systemic immune-inflammation index (SII), a relatively novel inflammatory index that combines peripheral lymphocyte, neutrophil, and platelet counts, can be obtained without any additional financial burden. A growing body of studies has shown the potential prognostic value of POD for head and neck free-flap reconstruction, abdominal surgery, esophagectomy, carotid endarterectomy and cardiac surgery [14][15][16][17][18]. However, few studies have shown that the SII can be used to predict postoperative delirium (POD) in older hip fracture patients, particularly those with intertrochanteric fractures.…”

Section: Introductionmentioning

confidence: 99%

Association between increased systemic immune-inflammation index and postoperative delirium in older intertrochanteric fracture patients

Yan,

Huang,

Chen

et al. 2024

J Orthop Surg Res

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Background and purpose The systemic immune-inflammation index (SII), a novel inflammation index derived from the counts of circulating platelets, neutrophils and lymphocytes, has been studied in the treatment of acute cancer and ischemic stroke (AIS). However, the clinical value of the SII in postoperative delirium patients has not been further investigated. The purpose of our research was to study the incidence and preoperative risk factors for postoperative delirium (POD) and verify whether the SII could serve as a potential marker for POD in older intertrochanteric fracture patients. Finally, we created a novel nomogram for predicting POD in older patients with intertrochanteric fractures. Methods We enrolled elderly patients with intertrochanteric fractures who underwent proximal femoral nail antirotation (PFNA) between February 2021 and April 2023. Univariate and multivariate logistic analyses were subsequently performed to confirm the risk factors and construct a nomogram model.Calibration curve and clinical decision curve analysis (DCA) were used to assess the model’s fitting performance. The performance of the nomogram was evaluated for discrimination, calibration, and clinical utility. Results A total of 293 patients were eligible for inclusion in the study, 25.6% (75/293) of whom had POD. The POD patients had higher SII values than the non-POD patients. The SII was strongly correlated with POD in older intertrochanteric fracture patients, and the optimal cutoff value was 752.6 × 109. Multivariate analysis revealed that age, diabetes, total albumin, SII > 752.6 × 109 and a CRP > 20.25 mg/L were independent risk factors for POD patients. By incorporating these 5 factors, the model achieved a concordance index of 0.745 (95% CI, 0.683–0.808) and had a well-fitted calibration curve and good clinical application value. Conclusion The SII is a simple and valuable biomarker for POD, and the new nomogram model can be used to accurately predict the occurrence of POD. They can be utilized in clinical practice to identify those at high risk of POD in older intertrochanteric fracture patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Association between increased systemic immune-inflammation index and postoperative delirium in older intertrochanteric fracture patients

Yan,

Huang,

Chen

et al. 2024

J Orthop Surg Res

View full text Add to dashboard Cite

show abstract

“…Several in ammatory markers in serum or cerebrospinal uid have been proven to be closely associated with POD [9] .Systemic immune-in ammation index (SII), a relatively novel in ammatory index combining peripheral lymphocytes, neutrophils, and platelet counts, can be obtained without any additional nancial burden. There is a growing body of studies that have shown the potential prognostic value of prediction of POD for head and neck free-ap reconstruction, abdominal surgery, esophagectomy, carotid endarterectomy and cardiac Surgery [10][11][12][13][14] . However, few studies have found that the SII can be applied to predict postoperative delirium (POD) in older hip fracture patients, particularly intertrochanteric fractures.…”

Section: Introductionmentioning

confidence: 99%

Association between increased Systemic Immune-Inflammation Index and postoperative delirium in older intertrochanteric fracture patients

Yan,

Huang,

Chen

et al. 2023

Preprint

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Background and Purpose Systemic immune-inflammation index (SII), a novel inflammation index derived from counts of circulating platelets, neutrophils and lymphocytes, has been studied in developing incident acute cancer and ischemic stroke (AIS). However, the clinical value of SII in postoperative delirium patients had not been further investigated. The purpose of our research was to study the incidence and preoperative risk factors for postoperative delirium (POD) and verify whether SII could serve as a potential marker for POD in older intertrochanteric fracture patients. Finally, we create a novel nomogram for predicting POD patients with older intertrochanteric fracture. Methods We enrolled elderly patients with intertrochanteric fracture who underwent proximal femoral nail anti-rotation(PFNA)between February 2021 to April 2023. Uni variate and multivariate logistic analyses were performed to confirm the risk factors and then construct a nomogram model. The calibration curve and clinical decision curve analysis (DCA) were used to assess the model’s fitting performance. The performance of the nomogram was evaluated for discrimination, calibration, and clinical utility. Results 293 patients were eligible for inclusion in the study, 25.6% (75/293) of patients had POD. The POD patients had higher SII levels than the non-POD group. SII is the stronger correlator for POD in older intertrochanteric fracture patients, of which the optimal cut-off value was 752.6×109. Multivariate analysis revealed that the age, diabetes, total albumin,SII > 752.6×109 and CRP > 20.25mg/L were independent risk factors for POD patients. Incorporating these 5 factors, the model achieved a concordance index of 0.745 (95% CI, 0.683–0.808) and had a well-fitted calibration curve and good clinical application value. Conclusion The SII was a simple and valuable biomarker for POD, and the new nomogram model based on it can accurately forecast the occurrence of POD. They can be utilized in clinical practice to identify those at high risk of POD in older intertrochanteric fracture patients.

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Reply to “In reference to preoperative serum biomarkers in the prediction of postoperative delirium following abdominal surgery”

Cited by 2 publications

References 4 publications

Association between increased systemic immune-inflammation index and postoperative delirium in older intertrochanteric fracture patients

Association between increased systemic immune-inflammation index and postoperative delirium in older intertrochanteric fracture patients

Association between increased Systemic Immune-Inflammation Index and postoperative delirium in older intertrochanteric fracture patients

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